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1998 articles

October 202624

Case ReportPediatrics

Recurrent Ovarian Torsion Despite Previous Oophoropexy in a 9-Year-Old Prepubertal Girl: A Pediatric Emergency Department Perspective.

A 9-year-old prepubertal girl with prior left ovarian torsion treated by laparoscopic detorsion and oophoropexy presented with severe intermittent left-sided abdominal pain and vomiting.

Am J Case RepOct 7, 2026Read case
Clinical ResearchInfectious Diseases

Three Months of Weekly Rifapentine and Isoniazid Versus Four Months of Daily Rifampicin for Tuberculosis Infection: A Randomized Controlled Trial.

This multicenter, open-label randomized controlled trial compared treatment completion with weekly isoniazid plus rifapentine for 3 months (3HP) versus daily rifampicin for 4 months (4RIF) among people of any age with…

Clin Infect DisOct 7, 2026Read summary
Case ReportPsychiatryOpen access

Managing 7-Hydroxymitragynine Use Disorder with Buprenorphine-Naloxone.

A patient who had used kratom to stop illicit opioids developed tolerance and transitioned to 7-hydroxymitragynine, believing the plant-derived product was safe.

Hawaii J Health Soc WelfOct 7, 2026Read case
Clinical ResearchRheumatology

Prospective controlled study of the recombinant zoster vaccine in autoimmune rheumatic disease: robust seroconversion despite intravenous cyclophosphamide.

This subanalysis of a prospective, randomized, placebo-controlled trial assessed recombinant zoster vaccine (RZV) responses in patients with autoimmune rheumatic disease receiving intravenous cyclophosphamide (IVCYC)…

VaccineOct 7, 2026Read summary
Case ReportAnesthesiologyOpen access

Effect of a Single Subanesthetic Dose of Esketamine on Gastrointestinal Recovery After Laparoscopic Colorectal Cancer Surgery: A Randomized, Outcome-Assessor-Blinded, Placebo-Controlled Trial.

Postoperative gastrointestinal dysfunction (POGD) and Postoperative gastrointestinal intolerance (POGI) remain a critical challenge in abdominal surgery, particularly for colorectal cancer patients undergoing…

Drug Des Devel TherOct 7, 2026Read case
Case ReportOncology (Medical)

Case report: successful use of repotrectinib in a ROS1 fusion-positive lung adenocarcinoma patient with severe renal insufficiency and prior tyrosine kinase inhibitor treatment failure.

A 69-year-old woman with advanced lung adenocarcinoma harboring an SDC4–ROS1 fusion had bilateral pulmonary lesions, mediastinal lymphadenopathy, and pleural effusions.

Anticancer DrugsOct 7, 2026Read case
Case ReportNeurologyOpen access

Parkinsonism with Reduced Striatal Uptake on DAT-SPECT in a Patient Harboring a Novel KCND3 Variant.

A Japanese patient with a novel KCND3 missense variant classified as a variant of uncertain significance had childhood-onset, slowly progressive cerebellar ataxia and asymmetric parkinsonism, a phenotype compatible with…

CerebellumOct 7, 2026Read case
Case ReportHematology

Successful treatment of hairy cell leukemia with TP53 abnormality using cladribine combined with low-dose rituximab: a case report and literature review.

An elderly man with classical hairy cell leukemia (HCL) had BRAF V600E positivity, a TP53 deletion detected by fluorescence in situ hybridization, and bone marrow fibrosis.

Anticancer DrugsOct 7, 2026Read case
Clinical ResearchAnesthesiology

Daily sedation interruption versus no daily sedation interruption for critically ill adults and children requiring invasive mechanical ventilation.

This updated Cochrane systematic review and meta-analysis assessed daily sedation interruption (DSI) versus sedation strategies without interruption in critically ill adults and children receiving invasive mechanical…

Cochrane Database Syst RevOct 7, 2026Read summary
Clinical ResearchOncology (Medical)

Chemotherapy backbone and outcomes of immune checkpoint inhibitor combinations across solid tumors: a pan-tumor network meta-analysis.

This systematic review and network meta-analysis examined phase II–III randomised trials comparing first-line immune checkpoint inhibitor (ICI) plus chemotherapy with chemotherapy alone across solid tumours, assessing…

OncologistOct 7, 2026Read summary
Clinical ResearchOncology (Medical)

Dose response relationship of medical cannabis and symptom control in patients with pancreatic cancer: an analysis of the CANPAN trial.

This analysis of the CANPAN pilot waitlist-control randomized trial examined cannabis use, patient-reported outcome completion, and THC dose-response among 32 cannabis-naïve patients with newly diagnosed locally…

OncologistOct 7, 2026Read summary
Clinical ResearchInfectious Diseases

A Phase 1/2 Dose-Ranging Safety and Immunogenicity Study of mRNA-Based Candidate Pandemic Influenza Vaccines in Healthy Adults.

This randomised phase 1/2 dose-ranging study evaluated the safety, reactogenicity, and immunogenicity of mRNA-1018 pandemic influenza vaccine candidates in healthy adults.

Clin Infect DisOct 7, 2026Read summary
Case ReportPulmonologyOpen access

Clinical features of cough syncope: a systematic review.

The article presents five cases of cough syncope and reviews published clinical characteristics, comprising 60 patients with a mean age of 56 ± 15 years; 91% were male.

Neurol SciOct 7, 2026Read case
Clinical ResearchDermatology

Acrokeratosis paraneoplastica (Bazex syndrome): a systematic review and quantitative analysis of 106 cases.

Acrokeratosis paraneoplastica (Bazex syndrome) is an obligate paraneoplastic dermatosis characterized by symmetrical acral psoriasiform lesions and nail dystrophy.

OncologistOct 7, 2026Read summary
Clinical ResearchPsychiatryOpen access

Anxiety and Depression in Athletes of Different Levels Without Current Injury: A Systematic Review With Meta-Analyses.

This systematic review and random-effects meta-analysis examined anxiety and depression in athletes across competitive levels, including those without current injury.

J Athl TrainOct 7, 2026Read summary
Clinical ResearchCardiology

EACTS Expert Consensus Document on aortic valve repair and valve-sparing aortic root replacement procedures.

This EACTS Expert Consensus Document critically reviews evidence on aortic valve repair and valve-sparing aortic root replacement for aortic regurgitation and proximal thoracic aortic aneurysms across age groups.

Eur J Cardiothorac SurgOct 7, 2026Read summary
Case ReportNeurologyOpen access

Multiple Sclerosis During Pregnancy and the Postpartum Period: Diagnostic and Multidisciplinary Challenges in Two Cases.

The report describes two pregnant women with progressive focal neurological symptoms and brain MRI abnormalities concerning for central nervous system demyelination.

Int Med Case Rep JOct 7, 2026Read case
Clinical ResearchInfectious Diseases

Safety and Immunogenicity of the Live-Attenuated Quadrivalent Dengue Vaccine V181 Compared With Butantan-DV Among Healthy Adults in Brazil: A Randomized, Double-Blind, Phase 2 Trial.

This randomized, double-blind, active-comparator phase 2 trial compared the safety and immunogenicity of single-dose quadrivalent dengue vaccines V181 and Butantan-DV in healthy adults in Brazil.

Clin Infect DisOct 7, 2026Read summary
Clinical ResearchInfectious DiseasesOpen access

Efficacy of direct-acting antiviral regimens for acute HCV infection: a systematic review and meta-analysis.

This systematic review and meta-analysis assessed interferon-free dual direct-acting antiviral regimens for acute or recently acquired HCV infection.

Virol JOct 7, 2026Read summary
Clinical ResearchInfectious Diseases

Multidimensional Poverty and Implementation Reach of Household Contact Tracing for Tuberculosis in South Africa: Analysis of a Randomized Trial.

This analysis of a cluster-randomized trial in South Africa examined whether household multidimensional poverty was associated with the reach of household contact tracing (HHCT) for tuberculosis.

Clin Infect DisOct 7, 2026Read summary
Clinical ResearchInfectious Diseases

Immunogenicity and Safety of the Adjuvanted Respiratory Syncytial Virus Prefusion F Protein-Based Vaccine When Co-administered With the Adjuvanted Recombinant Herpes Zoster Subunit Vaccine in Adults ≥ 50 Years of Age.

This phase III, open-label, randomised trial compared co-administration of adjuvanted RSVPreF3 and recombinant zoster vaccine (RZV) with administration one month apart in adults aged ≥50 years.

Clin Infect DisOct 7, 2026Read summary
Clinical ResearchGeneral Surgery

Preoperative pathways in adults with multiple long-term conditions undergoing major surgery: a systematic review.

This systematic review examined preoperative interventions, pathways and protocols for adults with multiple long-term conditions (MLTCs) undergoing major surgery.

BMJ OpenOct 7, 2026Read summary
Clinical ResearchHematologyOpen access

T-cell-redirecting therapies in early relapsed multiple myeloma: a systematic review and network meta-analysis.

This systematic review and network meta-analysis compared T-cell-redirecting regimens in randomized phase 3 trials involving patients with multiple myeloma after at least one prior line.

J Hematol OncolOct 7, 2026Read summary
Clinical ResearchNeurologyOpen access

Healthcare costs and burden of myasthenia gravis for patients and society: a systematic review.

This systematic review examined healthcare and societal costs associated with myasthenia gravis (MG), including 44 studies selected from 1,374 records.

J NeurolOct 7, 2026Read summary

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