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1333 articles
October 202624
The predictive value of early-pregnancy mean platelet volume for preeclampsia: A meta-analysis.
This meta-analysis assessed whether mean platelet volume (MPV) measured before 20 weeks’ gestation is associated with subsequent preeclampsia.
Phase 1 dose escalation and expansion trial of the bispecific CD47 inhibitor and CD40 agonist Fc-fusion protein SL-172154 (SIRPα-Fc-CD40L) in patients with higher-risk myelodysplastic syndrome or acute myeloid leukemia.
This Phase I clinical trial evaluated the safety and efficacy of the bispecific CD47 inhibitor SL-172154 combined with azacitidine (AZA) in patients with higher-risk myelodysplastic syndrome (HR-MDS) or acute myeloid…
TMS-Derived Neurophysiological Measures of Corticospinal Excitability, Intracortical Excitability, and Interhemispheric Interactions Associated With Post-Stroke Motor Recovery: A Systematic Review.
This systematic review evaluated the relationship between TMS-derived neurophysiological measures and motor recovery in adults post-stroke, synthesizing data from 16 randomized controlled trials.
Davos@home: Integrating objective home monitoring into eHealth self-management support after alpine altitude climate treatment for severe asthma.
This 12-month pragmatic randomised trial assessed whether objective home monitoring adds benefit to eHealth self-management after Alpine Altitude Climate Treatment (AACT) in adults with severe asthma.
Avutometinib, Abemaciclib, and Fulvestrant in Patients with HR+/HER2- Metastatic Breast Cancer Previously Treated with CDK4/6 Inhibitor: A Single-Arm Phase I Trial.
This single-arm phase I trial evaluated the combination of avutometinib, abemaciclib, and fulvestrant in 16 patients with HR+/HER2- metastatic breast cancer who had previously progressed on CDK4/6 inhibitors.
Effects of Yoga on Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the effects of yoga on psychological function and inflammation in individuals with rheumatoid arthritis (RA).
Online stepped care for the treatment of posttraumatic stress disorder: A randomized controlled noninferiority trial.
This randomized controlled non-inferiority trial compared online stepped care with telehealth cognitive processing therapy (CPT) in 84 adults with PTSD or subthreshold PTSD.
Lenalidomide-Related Diarrhea in Patients with Multiple Myeloma Is Associated with Gut Microbiota Dysbiosis and Disruption of the Bile Acid Pool.
This Phase II randomized controlled trial investigated the relationship between gut microbiota dysbiosis, bile acid pool disruption, and lenalidomide-related diarrhea (LRD) in patients with multiple myeloma.
Efficacy and Safety of Lorundrostat for Uncontrolled and Treatment-resistant Hypertension: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
This systematic review and meta-analysis evaluated the efficacy and safety of lorundrostat in adults with uncontrolled or treatment-resistant hypertension.
Efficacy and Safety of CETP Inhibitors in Patients With Atherosclerotic Cardiovascular Disease: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
This systematic review and meta-analysis evaluated the efficacy and safety of cholesteryl ester transfer protein (CETP) inhibitors in 62,565 patients with atherosclerotic cardiovascular disease.
Association of HRD Score With Efficacy of Neoadjuvant Short-Course Radiotherapy Plus Sequential Chemoimmunotherapy in pMMR Locally Advanced Rectal Cancer.
This Phase II clinical trial examined the relationship between homologous recombination deficiency (HRD) score and treatment response in 32 patients with mismatch repair-proficient locally advanced rectal cancer…
Diagnostic Accuracy of Circulating MicroRNAs for Coronary Artery Disease: An Updated Systematic Review and Meta-analysis.
This systematic review and meta-analysis evaluated the diagnostic accuracy of circulating microRNAs (miRNAs) for coronary artery disease (CAD) in 3,879 participants across 24 studies.
Female Soccer Players at High Risk of Injury Maintained Improved Knee Abduction Load 6 Months After Neuromuscular Training Program.
This randomized controlled trial evaluated the effects of a 6-week neuromuscular training (NMT) program on knee abduction moment (KAM) in 150 adolescent female soccer players.
A Composite Ovine Forestomach Matrix and Hyaluronic Acid CAMP for the Treatment of Full Thickness Wounds of the Foot in People With Diabetes: A Randomized Controlled Trial.
This randomized controlled trial evaluated the efficacy of a novel composite CAMP, OFM-HA, in treating full thickness diabetic foot ulcers (DFUs) in 143 patients.
Factors affecting the experience of procedural and postoperative pain in children and adolescents - a systematic review.
This systematic review examined factors influencing procedural and postoperative pain in children and adolescents aged 3-18 years.
The Use of Deliberate Practice in Simulation-Based Surgical Training for Open General and Subspeciality Surgery: A Systematic Review.
This systematic review evaluates the integration of deliberate practice (DP) in simulation-based surgical training (SBST) for open general and subspecialty surgery.
Factors influencing access to green health prescribing in primary care for older adults - a qualitative systematic review.
This systematic review examined barriers and enablers to green health prescribing (GHP) for older adults with long-term conditions.
Evaluating plasma ferritin and suPAR as treatable traits for critically ill patients with COVID-19 treated with anakinra: an exploratory analysis of the immune modulation domain of the REMAP-CAP randomised clinical trial.
This exploratory analysis of the REMAP-CAP randomized clinical trial evaluated plasma ferritin and suPAR as potential treatable traits for anakinra in critically ill COVID-19 patients.
Xiaoaiping Injection Combined with Chemotherapy Versus Chemotherapy Alone for Breast Cancer: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed the efficacy and safety of Xiaoaiping Injection (XAP) combined with chemotherapy versus chemotherapy alone in breast cancer patients.
Opioid-Sparing Analgesia After Laparoscopic Gastrectomy: Exploratory Clinical Outcomes and Cine-MRI Assessment of Small-Bowel Motility.
This randomized controlled trial evaluated opioid-sparing multimodal analgesia versus conventional opioid analgesia in 130 patients undergoing laparoscopic radical gastrectomy.
Portable Dynamometry Is Reliable for Measuring Knee and Ankle Strength in Daily Practice: Results From a Systematic Review With Meta-analysis and Evidence Gap Map Using the COSMIN Methodology.
This systematic review and meta-analysis evaluated the reliability and criterion validity of portable dynamometers for measuring knee and ankle muscle strength in both uninjured individuals and those with lower-limb…
Clinical trial: The Effect on Intragastric pH and Pharmacokinetics of the PCAB Linaprazan Glurate in Healthy Subjects After Repeat-Dose Administration for up to 14 Days.
This open, randomised, parallel-group Phase 1 trial assessed intragastric pH and pharmacokinetics after single and repeated linaprazan glurate (LG) dosing in 73 healthy subjects.
Biologics and Small-Molecule Inhibitors for the Treatment of Nummular Eczema: A Systematic Review.
This systematic review evaluated the efficacy of biologics and small-molecule inhibitors for treating nummular eczema (NE) by analyzing 10 studies.
Pediatric Literacy Promotion for Latino Families by Texts and Referrals: A 3-Arm RCT.
This randomized controlled trial evaluated two strategies to enhance literacy promotion among 630 Latino caregiver-infant dyads.
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