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751 articles
October 202616
Thyrotoxicosis-Associated Cholestatic Jaundice in a Patient With Incidental Gallstone Disease: A Case Report and Literature Review.
A 62-year-old woman presented with right upper quadrant pain, weight loss, and jaundice. Laboratory tests indicated cholestatic liver injury, and imaging revealed a solitary gallstone and signs of right-sided heart…
Diabetic Neuropathies.
This article provides an update on the biological mechanisms and risk factors for the varied manifestations of diabetes-associated nerve injury, and reviews current diagnostic and treatment approaches.
Native collagen matrix plus PHMB antimicrobial in hard-to-heal diabetic foot ulcers: results from the PREPARE randomised controlled trial.
The PREPARE prospective, multicentre randomised controlled trial compared purified native type 1 collagen extracellular matrix plus polyhexamethylene biguanide (PCMP) with standard care (SoC) alone in patients with…
Effect of a walnut-based low carbohydrate diet on fat redistribution and visceral fat accumulation in people with central obesity: A randomized controlled trial.
This randomized controlled trial investigated the effects of a walnut-based low carbohydrate diet (w-LCD) on fat redistribution and visceral fat accumulation in individuals with central obesity over 12 weeks.
Pharmacokinetic and Pharmacodynamic Drug-Drug Interactions Between Cofrogliptin and Metformin in Healthy Subjects: A Single-Center, Single-Arm, Phase I Study in China.
This single-center, single-arm Phase I study assessed drug-drug interactions between cofrogliptin and metformin in 22 healthy Chinese subjects.
Behavioral Interventions in Pediatric Type 1 Diabetes Management: An Updated Meta-Analysis.
This updated meta-analysis evaluated the impact of behavioral interventions on hemoglobin A1C (HbA1C) in youths with type 1 diabetes (T1D) across 46 randomized controlled trials.
Insights into diagnosis and management of giant adrenal pseudocysts.
A young man presented with headaches and mild anaemia, leading to imaging that revealed a giant left adrenal cystic lesion measuring 19×15×15 cm. Despite indeterminate CT findings, PET imaging suggested a benign nature.
Reporting Gaps in mHealth Intervention Studies for Adults With Diabetes: Systematic Review.
This systematic review evaluated the reporting completeness of 144 randomized controlled trials (RCTs) on mHealth interventions for adults with diabetes using the mERA checklist.
The role of vitamin D signalling in β cell apoptosis: a systematic review.
This systematic review examined the role of vitamin D signalling in pancreatic β-cell apoptosis, analyzing 26 studies across various models.
Cellular, Acellular, and Matrix-Like Placental Products for Diabetic Foot Ulcers: A 12-Week Randomised-Trial Meta-Analysis.
This meta-analysis evaluated the effectiveness of placental-derived cellular, acellular, and matrix-like products (CAMPs) as adjuncts to standard care for diabetic foot ulcers (DFUs) in adults.
A Composite Ovine Forestomach Matrix and Hyaluronic Acid CAMP for the Treatment of Full Thickness Wounds of the Foot in People With Diabetes: A Randomized Controlled Trial.
This randomized controlled trial evaluated the efficacy of a novel composite CAMP, OFM-HA, in treating full thickness diabetic foot ulcers (DFUs) in 143 patients.
Screening Strategies for Silent Myocardial Ischemia in Individuals With Diabetes Without Known Coronary Artery Disease: Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the effectiveness of routine screening for silent myocardial ischemia in asymptomatic adults with diabetes and no known coronary artery disease.
Bone Accrual During Puberty Suppression and Gender-Affirming Therapy in Transgender Adolescents: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated bone mineral density (BMD) and z scores in transgender adolescents undergoing gonadotropin-releasing hormone agonist (GnRHa) therapy followed by gender-affirming…
Calcitonin-negative 'MTC-like' thyroid paraganglioma revealing an SDHD-related hereditary paraganglioma syndrome: functional confirmation of a non-canonical splice-site variant.
A 36-year-old woman presented with a 20-mm thyroid nodule classified as EU-TIRADS 4 and Bethesda III, with normal serum calcitonin levels.
Exceptional and Durable Response to Selpercatinib in a Patient with Apparently RET -Negative, HRAS -, and NF1 -Mutated Metastatic Medullary Thyroid Carcinoma.
A 50-year-old woman presented with rapidly progressive medullary thyroid carcinoma (Ki-67 30%) and extensive liver and bone metastases.
Effects of sprint interval training on markers of metabolic health: A three-level meta-analysis of randomised controlled trials.
This systematic review and three-level meta-analysis examined randomised controlled trials comparing sprint interval training (SIT) with no-exercise control or moderate-intensity continuous training (MICT) for metabolic…
September 20268
Acute variceal bleeding in a patient with phaeochromocytoma: the critical choice of vasoactive therapy.
A woman in her late 70s with a known left-sided phaeochromocytoma experienced acute variceal bleeding, likely due to cirrhosis. Due to the risk of hypertensive crisis, terlipressin was not used.
Lipomatous pseudohypertrophy of pancreas with chronic calcific pancreatitis presenting with nutritional dermatosis and type 3c diabetes.
A woman in her early 50s presented with erythema, scaling of the limbs, weight loss, anasarca, and chronic foul-smelling diarrhea, indicative of nutritional dermatosis due to malabsorption.
The oral und systemic health risks of sugar consumption: an umbrella review.
This umbrella review analyzed systematic reviews to assess the health risks associated with free sugar consumption, focusing on both oral and systemic health.
Supporting Caregivers Behind Youth with T1D: A Systematic Review of Psychosocial Interventions and Youth Glycemic Outcomes.
This systematic review analyzed 26 studies on psychosocial interventions for parents of children with Type 1 Diabetes (T1D) from 2019 to 2025.
Urinary dipstick findings and UTI risk with SGLT2 inhibitors: a post-hoc analysis of the CANVAS and CREDENCE trials.
This post-hoc analysis of the CANVAS and CREDENCE trials evaluated the relationship between urinary dipstick findings and UTI risk in 8614 participants with type 2 diabetes.
Perioperative Offloading for Diabetic Foot Ulcers: A Systematic Review and Evidence Synthesis.
This systematic review evaluated perioperative offloading strategies for diabetic foot ulcer (DFU) management, synthesizing evidence from 15 publications, including guidelines and expert consensus.
Safety and efficacy of human gingiva-derived mesenchymal stem cells in patients with type 1 diabetes: a double-blind, randomized, placebo-controlled, phase 1 trial.
This phase 1 double-blind, randomized, placebo-controlled trial evaluated the safety and efficacy of human gingiva-derived mesenchymal stem cells (GMSCs) in 18 patients with type 1 diabetes mellitus (T1DM).
Cardiovascular safety of orforglipron versus insulin glargine in adults with type 2 diabetes at increased cardiovascular risk (ACHIEVE-4): a phase 3, event-driven, randomised, open-label, non-inferiority, active comparator trial.
ACHIEVE-4 was a phase 3, event-driven, multicentre, randomised, open-label, active-comparator non-inferiority trial comparing once-daily oral orforglipron with titrated insulin glargine in adults with type 2 diabetes…
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