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1333 articles
September 202624
Lower HLA-B27 positivity and heterogeneous late-onset case proportions across axial spondyloarthritis cohorts: a systematic review and meta-analysis.
This systematic review and meta-analysis examined late-onset ankylosing spondylitis (AS) and axial spondyloarthritis (axSpA) in clinical cohorts, focusing on cases with onset at or after age 45.
Safety and efficacy of human gingiva-derived mesenchymal stem cells in patients with type 1 diabetes: a double-blind, randomized, placebo-controlled, phase 1 trial.
This phase 1 double-blind, randomized, placebo-controlled trial evaluated the safety and efficacy of human gingiva-derived mesenchymal stem cells (GMSCs) in 18 patients with type 1 diabetes mellitus (T1DM).
Does baseline physical function modify the response to a physical activity intervention in adults with arthritis? A secondary analysis of a randomized trial.
This secondary analysis of a randomized controlled trial examined whether baseline physical function influenced the response to a telephone-delivered Walk With Ease (WWE-T) intervention in 267 adults with arthritis.
A community-based participatory research and community health workers-led health education strategy for schistosomiasis control among schoolchildren in Pemba Island, Zanzibar: a cluster-randomized trial.
This cluster-randomized controlled trial evaluated a community-based participatory research (CBPR) approach led by community health workers for schistosomiasis control among schoolchildren in Pemba, Zanzibar.
8 weeks versus 12 weeks of sofosbuvir-velpatasvir for treatment-naive, non-cirrhotic, chronic hepatitis C (RESOLVE): a multicentre, open-label, non-inferiority, randomised controlled trial in India.
The RESOLVE multicentre, open-label, randomised non-inferiority trial compared 8 versus 12 weeks of daily sofosbuvir-velpatasvir in treatment-naive adults with chronic hepatitis C without cirrhosis at five publicly…
16S rRNA Datasets of Gut Microbiota in Stent-Based Diverting Technique and Ileostomy from A Prospective, Open-Label, Multicenter Randomized Controlled Trial.
This study presents a 16S rRNA amplicon dataset from a multicenter randomized controlled trial involving 80 patients undergoing either a stent-based diverting technique (SDT) or ileostomy after rectal cancer surgery.
Cardiovascular safety of orforglipron versus insulin glargine in adults with type 2 diabetes at increased cardiovascular risk (ACHIEVE-4): a phase 3, event-driven, randomised, open-label, non-inferiority, active comparator trial.
ACHIEVE-4 was a phase 3, event-driven, multicentre, randomised, open-label, active-comparator non-inferiority trial comparing once-daily oral orforglipron with titrated insulin glargine in adults with type 2 diabetes…
Clinical, economic, and quality-of-life outcomes of brexucabtagene autoleucel for the treatment of relapsed/refractory mantle cell lymphoma and B-cell acute lymphoblastic leukemia: A systematic literature review and meta-analysis.
This systematic literature review and meta-analysis evaluated the clinical, healthcare resource use, and quality-of-life outcomes of brexucabtagene autoleucel in adults with relapsed/refractory mantle cell lymphoma…
Effectiveness, Mediators and Moderators of Remote Live vs. Pre-Recorded Physical Exercise Training for Chronic Low Back Pain.
This randomized controlled trial evaluated the effectiveness of live interactive versus pre-recorded remote exercise training for chronic low back pain (CLBP) in 94 patients.
Reducing Peripheral Intravenous Catheter Use in Adult Acute Care: A Systematic Review.
This systematic review evaluated interventions aimed at reducing peripheral intravenous catheter (PIVC) use in adult acute care settings.
More than meets the eye: A meta-analysis of visual outcomes following clipping, coiling, and flow diversion for visually symptomatic paraclinoid aneurysms.
This PRISMA-compliant systematic review and random-effects meta-analysis compared visual outcomes after clipping, coiling, and flow diversion for paraclinoid aneurysms, drawing on 21 studies.
First systematic mapping of non-target [68Ga]Ga-DOTANOC uptake across anatomical sites and etiologies.
This systematic review analyzed 76 studies involving 542 patients to map non-target [68Ga]Ga-DOTANOC uptake across various anatomical sites and etiologies.
Doing the groundwork at home, working through it together: patient experiences of blended cognitive therapy for PTSD in routine care.
This qualitative study explored patient experiences with blended trauma-focused cognitive therapy (bTF-CT) for PTSD in routine care, involving 11 participants.
Rituximab as Rescue or Add-On Therapy for Relapsing or Refractory Lupus Nephritis: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the efficacy of rituximab (RTX) as rescue or add-on therapy for relapsing or refractory lupus nephritis in 445 patients.
The association between disability and mortality among children and adolescents: A systematic review and meta-analysis.
This systematic review and meta-analysis examined all-cause mortality among children and adolescents with disabilities compared to non-disabled peers, analyzing 29 studies with over 35 million participants.
Supporting Caregivers Behind Youth with T1D: A Systematic Review of Psychosocial Interventions and Youth Glycemic Outcomes.
This systematic review analyzed 26 studies on psychosocial interventions for parents of children with Type 1 Diabetes (T1D) from 2019 to 2025.
Operative treatment of high-grade medial collateral ligament injury and chronic medial knee instability: a systematic review.
This systematic review assessed the operative treatment of high-grade medial collateral ligament (MCL) injuries and chronic medial knee instability, focusing on clinical phenotype rather than MCL grade.
Comparative Effectiveness and Safety of FOLFOXIRI Plus Cetuximab Versus FOLFOXIRI Plus Bevacizumab in Metastatic Colorectal Cancer: A GRADE-assessed Systematic Review and Meta-analysis.
This systematic review and meta-analysis evaluated the effectiveness and safety of FOLFOXIRI plus cetuximab versus FOLFOXIRI plus bevacizumab in 561 patients with metastatic colorectal cancer (mCRC).
The oral und systemic health risks of sugar consumption: an umbrella review.
This umbrella review analyzed systematic reviews to assess the health risks associated with free sugar consumption, focusing on both oral and systemic health.
Oral anticoagulant monotherapy versus oral anticoagulant plus antiplatelet therapy in adults with stable coronary artery disease.
This is a protocol for a Cochrane review (intervention). The objectives are as follows: To assess the benefits and harms of oral anticoagulant monotherapy compared with oral anticoagulant plus antiplatelet therapy in…
A high intensity vs. casual speed walking intervention to reverse frailty among older adults: a cluster randomized controlled trial.
This cluster-randomized controlled trial evaluated the effects of high-intensity walking (HIW) versus casual-speed walking (CSW) on frailty in 165 prefrail and frail adults aged ≥60 years.
Behavior Change and Compliance Outcomes of a Novel Web-Based Health Behavior Tool Integrated Into Certified Exercise Practitioner Services: Twelve-Week, Two-Arm, Randomized Pre-Post Trial.
This randomized controlled trial evaluated the impact of a web-based health behavior tool, the FESS questionnaire, on health behaviors in 41 older adults (median age 65) receiving services from certified exercise…
Knowledge Performance, User Experience, and Cybersickness With Immersive Virtual Reality for Tai Chi Movement-Encoding in Older Adults: Randomized Comparison Study.
This randomized controlled trial compared immersive virtual reality (VR) to 2D video instruction for Tai Chi movement-encoding in 106 community-dwelling older adults.
Association between personal birth companion and maternal mental health in low- and middle-income countries: a systematic review.
This systematic review examined the impact of personal birth companions on maternal mental health during labor and postpartum in low- and middle-income countries.
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