Trending archive
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1845 articles
July 202616
Phase I study of glofitamab in Japanese patients with relapsed or refractory B-cell non-Hodgkin lymphoma.
This Phase I study evaluated the safety, pharmacokinetics, and efficacy of glofitamab in Japanese patients with relapsed or refractory B-cell non-Hodgkin lymphoma.
Ablative radiotherapy in castration-resistant prostate cancer.
This randomized phase II trial evaluated the efficacy of metastasis-directed therapy (MDT) in patients with castration-resistant prostate cancer (CRPC) and up to five metastases.
Genomic and molecular landscape of early onset colorectal cancer: Emerging insights and clinical implications-A systematic review.
This systematic review analyzed the genomic and molecular characteristics of early onset colorectal cancer (EOCRC) in approximately 19,888 patients.
Artificial intelligence for predicting pathological complete response to neoadjuvant therapy in triple-negative breast cancer: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effectiveness of artificial intelligence (AI) models in predicting pathological complete response (pCR) to neoadjuvant therapy in early triple-negative breast…
Efficacy and safety of a novel oral anti-vasculogenic mimicry agent, CVM-1118, in advanced well-differentiated neuroendocrine tumors: a Phase IIa trial.
This Phase IIa trial evaluated the efficacy and safety of CVM-1118 in 43 patients with advanced well-differentiated neuroendocrine tumors (NETs) who were refractory to standard therapies.
Increased 18 F-FDG Avidity on PET/CT During Treatment for Rhabdomyosarcoma Confirmed to Be Mature Rhabdomyoblasts.
An adolescent with metastatic fusion-positive rhabdomyosarcoma exhibited a new 18 F-FDG-PET avid focus in the radiation field during systemic chemotherapy, raising concerns for disease progression.
Novel PET tracers to distinguish the nature of residual masses after the completion of chemotherapy in metastatic testicular germ cell tumours: A systematic review.
This systematic review evaluated novel PET tracers for assessing residual masses in metastatic testicular germ cell tumours (TGCTs) post-chemotherapy.
Temozolomide Versus Radiotherapy as First-Line Therapy for Low-Grade Glioma: Mature Results of a Randomized Phase III Trial (EORTC 22033-26033/NCIC-CTG/TROG/MRC-CTU).
This multicenter, randomized phase III trial compared first-line radiotherapy with dose-dense temozolomide in 478 patients with clinically high-risk WHO grade 2 low-grade glioma.
Diagnostic performance of artificial intelligence based on PET/CT for lymph node involvement in prostate cancer: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the diagnostic performance of PET/CT-based artificial intelligence (AI) models for detecting lymph node involvement in prostate cancer, comparing them to physician…
Case Report: Pancreatic Paraganglioma Mimicking a Well-Differentiated Neuroendocrine Tumor: The Importance of Cytokeratin Immunohistochemistry.
A 79-year-old woman presented with an incidental lesion in the pancreatic head, initially suspected to be a well-differentiated neuroendocrine tumor.
Concurrent chemoradiotherapy with or without simultaneous integrated boost for unresectable stage III non-small-cell lung cancer: a randomized phase II trial with exploratory EGFR and PD-L1 analyses.
This randomized phase II trial evaluated the impact of simultaneous integrated boost (SIB) radiotherapy on progression-free survival (PFS) and overall survival (OS) in 168 patients with unresectable stage III…
Germline pathogenic PTEN variant in a patient with a Kaposiform haemangioendothelioma.
A 28-year-old female presented with Kaposiform haemangioendothelioma (KHE) and was found to have a germline pathogenic PTEN variant. Initial detection in tumor tissue was confirmed in saliva.
Neuroprotection and prevention of oxaliplatin-induced neuropathy with Huangqi Guizhi Wuwu Decoction: a 12-center randomized, double-blind trial with mechanistic validation.
This multicenter, randomized, double-blind trial evaluated the efficacy of Huangqi Guizhi Wuwu Decoction (HQGZWWD) in preventing oxaliplatin-induced peripheral neuropathy (OIPN) in 360 adults with colorectal cancer…
Management considerations of ameloblastic carcinoma in soft-tissue: case report and literature review.
A 36-year-old woman with a history of mandibular ameloblastoma underwent segmental mandibulectomy and reconstruction. Three years later, she presented with a submental swelling, which was initially diagnosed as…
Liver Tumor Motion and Reconstructed Doses in a Clinical Trial of Respiratory-Gated Proton Therapy for Hepatocellular Carcinoma.
This prospective phase II clinical trial evaluated tumor motion and reconstructed delivered doses during respiratory-gated pencil beam scanning proton therapy in 16 patients with hepatocellular carcinoma.
Efficacy and Tolerability of Zenocutuzumab in Advanced NRG1 Fusion-Positive Cholangiocarcinoma: Results From the eNRGy Phase II Trial.
This single-arm, multicenter phase II trial evaluated zenocutuzumab in previously treated or standard-therapy-ineligible adults with advanced NRG1 fusion-positive cholangiocarcinoma.
June 20268
Perioperative tislelizumab for early-stage hepatocellular carcinoma: A phase II trial with integrated tumour microenvironment profiling and predictive modeling.
This phase II trial evaluated tislelizumab monotherapy as a neoadjuvant treatment for 36 patients with resectable early-stage hepatocellular carcinoma (HCC).
Hemophagocytic Lymphohistiocytosis and Fibroblast Growth Factor 23 (FGF23)-Induced Hypophosphatemia.
A patient with acute lymphoblastic leukemia developed severe, refractory hypophosphatemia characterized by renal phosphate wasting, triggered by hemophagocytic lymphohistiocytosis.
Kidney Transplantation Post-Chimeric Antigen Receptor (CAR) T-Cell Therapy in Multiple Myeloma.
A 71-year-old man with stage III multiple myeloma and end-stage kidney disease underwent ciltacabtagene autoleucel CAR T-cell therapy, achieving minimal residual disease (MRD)-negative status.
Lymphedema therapy in head & neck cancer with carotid stenosis: a systematic review and care pathway.
This systematic review aimed to develop a clinical care pathway for managing lymphedema in head and neck cancer survivors at risk for carotid atherosclerosis.
A phase 1 dose-finding and pharmacokinetic study of acasunlimab alone or in combination with pembrolizumab in Japanese patients with advanced or metastatic solid tumors.
This phase 1, open-label, dose-escalation trial assessed the safety and pharmacokinetics of acasunlimab, both alone and in combination with pembrolizumab, in Japanese patients with advanced or metastatic solid tumors.
Matching-Adjusted Indirect Comparison of Tarlatamab for Patients with Platinum-Refractory or Platinum-Resistant Extensive-Stage Small-Cell Lung Cancer.
This study conducted a matching-adjusted indirect comparison of tarlatamab versus paclitaxel and CAV in patients with platinum-refractory or platinum-resistant extensive-stage small-cell lung cancer (ES-SCLC).
Effect of malaria parasitaemia on antibody responses to single-dose and two-dose HPV vaccination: results from the DoRIS dose-reduction immunogenicity trial in Tanzanian girls.
This randomized controlled trial evaluated the impact of malaria parasitaemia on HPV vaccine immune responses in 930 HIV-negative Tanzanian schoolgirls aged 9-14 years.
Intense Incidental F-18 DOPA Uptake in Low-grade Prostate Adenocarcinoma: A Potential Diagnostic Pitfall.
A 60-year-old man presented for evaluation of elevated normetanephrines, during which intense incidental F-18 DOPA uptake was noted in the prostate on PET/CT.
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