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1998 articles
October 202624
Persistent influenza A RNA detection in a fatal pediatric case of influenza-associated encephalopathy.
A 9-year-old boy developed fulminant influenza-associated encephalopathy, a life-threatening complication of influenza. Despite life-sustaining support, intensive immunomodulatory treatment, and antiviral therapy…
Carbon nanoparticle-Fe (II) complex for ferroptosis therapy in refractory solid tumors: a phase I trial.
This phase I trial evaluated the safety and preliminary efficacy of a carbon nanoparticle-Fe (II) complex (CNSI-Fe) in 19 patients with refractory solid tumors.
Low-Dose Cytarabine Plus G-CSF Induction in Pediatric M2 Acute Myeloid Leukemia: A Multicenter Study.
This multicenter randomized controlled trial analyzed the efficacy and safety of low-dose chemotherapy (LDC) versus standard-dose chemotherapy (SDC) in 221 children with M2 acute myeloid leukemia.
New Primary and Secondary Prevention Measures for Cutaneous Melanoma: A Systematic Review.
This systematic review evaluated recent evidence on primary and secondary prevention strategies for cutaneous melanoma, analyzing 24 studies.
MicroRNAs Regulation of Axon Sprouting in Peripheral Nerve Regeneration: A Systematic Review.
This systematic review examines the role of microRNAs (miRNAs) in peripheral nerve regeneration, focusing on miR-21, miR-133b, miR-124, and miR-30b.
The role of vitamin D signalling in β cell apoptosis: a systematic review.
This systematic review examined the role of vitamin D signalling in pancreatic β-cell apoptosis, analyzing 26 studies across various models.
Cellular, Acellular, and Matrix-Like Placental Products for Diabetic Foot Ulcers: A 12-Week Randomised-Trial Meta-Analysis.
This meta-analysis evaluated the effectiveness of placental-derived cellular, acellular, and matrix-like products (CAMPs) as adjuncts to standard care for diabetic foot ulcers (DFUs) in adults.
Age- and sex-specific trends in Canadian mental health from 2003 to 2024: a repeated cross-sectional meta-regression analysis.
This meta-analysis examined trends in mental health outcomes in Canada from 2003 to 2024, using data from the Canadian Community Health Survey.
Remote robotic urological surgery with the Toumai® System across 25-7,000 km: a systematic review and single-arm meta-analysis of technical success and reported safety.
To summarize the early clinical experience with the Toumai ® robotic system in remote urological surgery and to descriptively synthesize technical success, perioperative outcomes, and network performance, while…
Resolution of restless legs syndrome after postdilution online hemodiafiltration using a vitamin E-bonded polysulfone membrane: a report of two cases.
Two patients with long-standing, refractory restless legs syndrome underwent high-efficiency online hemodiafiltration but did not achieve sufficient symptom relief.
Dose Considerations and Generalization Following Script Training for Poststroke Aphasia: A Randomized Factorial Clinical Trial.
This single-site, single-blind, 2 × 2 factorial randomized controlled trial examined how script length and session frequency affect treatment outcomes in 85 people with chronic poststroke aphasia.
Buruli Ulcer Acquired From Ringtail Possum Rescue.
A patient presented with a Buruli ulcer, which was likely acquired from a scratch by a ringtail possum during a rescue attempt. This case highlights a newly recognized transmission route for Buruli ulcer.
Felzartamab plus lenalidomide-dexamethasone versus lenalidomide-dexamethasone for relapsed or refractory multiple myeloma: an open-label, parallel-controlled, randomised, phase 3 trial.
This phase 3 randomized trial evaluated the efficacy of felzartamab combined with lenalidomide-dexamethasone versus lenalidomide-dexamethasone alone in Chinese patients with relapsed or refractory multiple myeloma.
Pearls & Oy-sters: Diagnosis of Pediatric Tumefactive Multiple Sclerosis With MRI Biomarkers.
A 16-year-old boy presented with subacute headaches, cognitive difficulties, dizziness, blurry vision, right arm weakness, numbness, and gait issues.
Rilzabrutinib, an oral Bruton tyrosine kinase inhibitor, in patients with warm autoimmune haemolytic anaemia: a prospective, single-arm, multicentre, phase 2b safety and clinical activity study (LUMINA 2).
The LUMINA 2 study evaluated the safety and clinical activity of rilzabrutinib, a Bruton tyrosine kinase inhibitor, in adults with warm autoimmune haemolytic anaemia.
Effects of high-dose supplemental oxygen therapy on pulmonary haemodynamics at 3250 m in high-altitude residents at risk for pulmonary hypertension.
This open-label, non-randomised trial investigated the effects of high-dose supplemental oxygen therapy (SOT) on pulmonary haemodynamics in Kyrgyz highlanders at 3250 m with elevated systolic pulmonary artery pressure…
Toripalimab consolidation after chemoradiotherapy in limited-stage small cell lung cancer: a phase II, randomized controlled study (GASTO-1052A).
This phase II randomized controlled trial evaluated the efficacy and safety of toripalimab consolidation after chemoradiotherapy in patients with limited-stage small cell lung cancer (LS-SCLC).
Long-term Follow-up of Third-generation Anti-CD30 CAR T-cell Therapy in Relapsed/Refractory CD30+ Lymphomas: A Single-Arm, Multicenter, Phase I/II Trial.
This single-arm, multicenter, phase I/II trial evaluated long-term outcomes of third-generation anti-CD30 CAR T-cell therapy in 44 patients with relapsed/refractory CD30+ lymphoma.
Toxin-induced coagulopathy following a MacMahon viper bite.
A patient presented with a MacMahon viper bite, experiencing significant local envenomation, hypotension, and syncope. Laboratory tests showed rapid thrombocytopenia and impaired haemostatic function.
Long-Term Safety and Efficacy of Dazukibart in Dermatomyositis: Combined Phase II Results From Double-Blind and Open-Label Extension Studies.
This study evaluated the long-term safety and efficacy of dazukibart, an antiinterferon β monoclonal antibody, in adults with moderate-to-severe dermatomyositis through a combined Phase II randomized controlled trial…
How I treat thrombotic microangiopathy in the setting of triggers.
A patient presented with thrombotic microangiopathy during pregnancy, which complicated the diagnosis due to the potential trigger.
Wound dehiscence following biportal endoscopic versus microscopic spine surgery for single-level lumbar decompression: a post hoc analysis of two randomized controlled trials.
This post hoc analysis of two randomized controlled trials compared wound dehiscence rates between biportal endoscopic spine surgery (BESS) and microscopic spine surgery (MSS) in 211 patients undergoing single-level…
Primary tongue leiomyosarcoma.
A male patient in his mid 50s presented with a non-healing ulcer on the right lateral border of the tongue, accompanied by impaired tongue movement.
A Phase 2, Open-Label, Randomized Controlled Trial Evaluating Safety and Efficacy of Dose-Intensified Versus Standard Dosing Regimens of [ 177 Lu]Lu-PSMA-597 in mCRPC (OPTIMAL-PSMA).
The OPTIMAL-PSMA study is a Phase 2, open-label, randomized controlled trial evaluating the safety and efficacy of a dose-intensified regimen of [177Lu]Lu-PSMA-597 versus standard dosing in 120 patients with metastatic…
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