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1998 articles
September 202624
Metastatic muscle invasive bladder cancer in pregnancy.
A woman in her 30s presented during the second trimester with hematuria and left flank pain. MRI identified a T3b bladder tumor with suspected peritoneal invasion.
'Once Bitten': A Case of Tetanus Following Snakebite in Australia.
A 58-year-old woman in Victoria, Australia, presented after a suspected Tiger snake bite. She was not current with her tetanus vaccination and did not receive a booster.
Effectiveness and safety of the available preventive tuberculosis treatment regimens for children and adolescents: systematic review and network meta-analysis.
This systematic review and network meta-analysis evaluated the effectiveness and safety of tuberculosis (TB) treatment regimens in children and adolescents under 18 years.
Anakinra versus intramuscular methylprednisolone acetate for gout flares in people with chronic kidney disease (ASGARD): a UK randomised multicentre, double-blind, double-dummy controlled feasibility study with economic, qualitative and safety assessment.
The ASGARD study was a feasibility randomized controlled trial comparing anakinra to intramuscular methylprednisolone acetate for treating gout flares in patients with chronic kidney disease.
Right Brain: Language Without Speech.
During a neurology rotation as a second-year internal medicine resident, I encountered a preschool-aged child whose absence of spontaneous speech initially framed my clinical thinking.
A phase 1b/2 study of ceralasertib, a selective inhibitor of ATR, in patients with relapsed or refractory MDS and CMML.
This phase 1b/2 study evaluated ceralasertib, an ATR inhibitor, in 44 adults with relapsed or refractory MDS and CMML. The overall response rate was 29.5%, with a median progression-free survival of 4.8 months and…
Performing lifestyle changes and reducing stroke risk: a process evaluation of a stroke prevention intervention.
This randomized controlled trial evaluated a stroke prevention intervention in Swedish primary healthcare, focusing on implementation processes and mechanisms of change among 122 high-risk participants.
Urinary dipstick findings and UTI risk with SGLT2 inhibitors: a post-hoc analysis of the CANVAS and CREDENCE trials.
This post-hoc analysis of the CANVAS and CREDENCE trials evaluated the relationship between urinary dipstick findings and UTI risk in 8614 participants with type 2 diabetes.
Methods for a Community-Engaged Randomized Trial for Urgency Incontinence.
The Beta-Agonist versus ONA Trial for Urgency Urinary Incontinence (BEST) is a multicenter, single-blinded randomized trial comparing the efficacy of beta-agonist medication and onabotulinumtoxinA injections in female…
Perioperative Offloading for Diabetic Foot Ulcers: A Systematic Review and Evidence Synthesis.
This systematic review evaluated perioperative offloading strategies for diabetic foot ulcer (DFU) management, synthesizing evidence from 15 publications, including guidelines and expert consensus.
Genetic Analysis and Reproductive Intervention in a Duchenne Muscular Dystrophy Family With Cryptic Complex Chromosomal Rearrangement Identified by Structural Variation Sequencing.
Duchenne/Becker muscular dystrophy (DMD/BMD) is caused by variants in the X-linked DMD gene-most commonly deletions, duplications, or point mutations, and only rarely by complex chromosomal rearrangements (CCRs).
Prognostic Models for Predicting the Severity and Mortality in People With Acute Pancreatitis - A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed how accurately four clinical scoring systems predict severe acute pancreatitis (SAP) and mortality in adults.
Clinical Reasoning: A 60-Year-Old Woman With Fever, Headache, Diplopia, and Unilateral Periorbital Swelling.
A 60-year-old woman presented with fever, headache, horizontal diplopia, and unilateral periorbital swelling after experiencing recurrent gingival swelling and pain for about a month.
Sex differences in the efficacy, acceptability, and tolerability of antipsychotics in people with acute schizophrenia: individual participant data pairwise, dose-response, and network meta-analyses.
This individual participant data pairwise, dose-response, and network meta-analysis examined sex differences in antipsychotic efficacy, acceptability, and tolerability in adults with acute schizophrenia.
Implementation of Total Body Photography for Skin Cancer Early Detection: A Systematic Review.
This systematic review examined how total body photography (TBP) has been implemented and used for skin cancer detection and surveillance across healthcare settings.
Endoscopic Ultrasound-Guided Hepaticogastrostomy With Plastic Stent Versus Metallic Stent for Malignant Biliary Obstruction: A Meta-Analysis.
This meta-analysis evaluated the efficacy and safety of plastic versus metal stents in endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) for malignant biliary obstruction.
Uterosacral Versus Sacrospinous Ligament Suspension in Pelvic Organ Prolapse: An RCT.
This randomized controlled trial compared high uterosacral ligament suspension (HUSLS) and sacrospinous ligament fixation (SSF) in women undergoing vaginal hysterectomy for pelvic organ prolapse (POP).
Efficacy of pancreatic enzyme replacement therapy on exocrine pancreatic insufficiency: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the efficacy of pancreatic enzyme replacement therapy (PERT) in improving nutrient absorption in patients with exocrine pancreatic insufficiency (EPI).
Percutaneous catheter drainage versus needle aspiration for liver abscess: a systematic review and meta-analysis of efficacy and safety.
This systematic review and meta-analysis evaluated the efficacy and safety of percutaneous catheter drainage (PCD) versus needle aspiration (PNA) for liver abscesses in 1425 adults.
A meta-analysis of transjugular intrahepatic portosystemic shunt with or without embolization for esophageal and gastric variceal bleeding in decompensated liver cirrhosis.
This meta-analysis evaluated the efficacy of transjugular intrahepatic portosystemic shunt (TIPS) with or without embolization in 3079 patients with decompensated liver cirrhosis experiencing esophageal and gastric…
A phase 1/1b study of the all-oral regimen CC-486 and venetoclax in acute myeloid leukemia.
This phase 1/1b study evaluated the all-oral regimen of CC-486 and venetoclax in patients with relapsed, refractory, and newly diagnosed acute myeloid leukemia (AML).
Isolated clival Langerhans cell histiocytosis in a pediatric patient: systematic review and illustrative case report.
A 3.5-year-old boy presented with isolated clival Langerhans cell histiocytosis, confirmed through histopathological and immunohistochemical evaluation.
Intracardiac vs. transesophageal echocardiography in patients undergoing ablation for atrial fibrillation: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the safety and efficacy of intracardiac echocardiography (ICE) versus transesophageal echocardiography (TEE) in 7671 patients undergoing catheter ablation for atrial…
Impact of EBV status and histology on patient outcomes with nivolumab-AVD vs BV-AVD in advanced classic Hodgkin lymphoma (S1826).
This phase 3 randomized controlled trial evaluated the impact of EBV status and histology on outcomes in patients with advanced classic Hodgkin lymphoma treated with nivolumab-AVD (N-AVD) versus brentuximab vedotin-AVD…
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