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497 articles
October 202618
Gastric neuroendocrine tumours after prolonged proton pump inhibitor use.
A woman in her 40s with chronic gastro-oesophageal reflux disease had been on proton pump inhibitors for 20 years. She was diagnosed with gastric neuroendocrine tumours during an upper endoscopy.
Primary tongue leiomyosarcoma.
A male patient in his mid 50s presented with a non-healing ulcer on the right lateral border of the tongue, accompanied by impaired tongue movement.
Resistant Hypertension Secondary to Renal Arteriovenous Malformation: A Case of Cure After Nephrectomy.
A 33-year-old woman with longstanding uncontrolled hypertension requiring five antihypertensive agents was evaluated for refractory blood pressure control.
New Primary and Secondary Prevention Measures for Cutaneous Melanoma: A Systematic Review.
This systematic review evaluated recent evidence on primary and secondary prevention strategies for cutaneous melanoma, analyzing 24 studies.
Molecular Profiling of Tisotumab Vedotin-Treated Patients Identifies Immune Pathways Associated with Clinical Activity.
This phase II multicenter trial evaluated the efficacy of tisotumab vedotin (TV) in patients with recurrent or metastatic cervical cancer (r/mCC).
Tumor-Infiltrating Lymphocytes as a Predictor of Adjuvant Avelumab Efficacy in Patients with High-risk Triple-Negative Breast Cancer.
This phase III randomized controlled trial investigated the prognostic and predictive value of tumor-infiltrating lymphocytes (TIL) in 466 patients with high-risk early triple-negative breast cancer (TNBC) receiving…
Association of HRD Score With Efficacy of Neoadjuvant Short-Course Radiotherapy Plus Sequential Chemoimmunotherapy in pMMR Locally Advanced Rectal Cancer.
This Phase II clinical trial examined the relationship between homologous recombination deficiency (HRD) score and treatment response in 32 patients with mismatch repair-proficient locally advanced rectal cancer…
Pediatric Spinal Cord Astrocytoma With Granular Cell-Like Morphology and KIAA1549::BRAF Fusion.
A pediatric patient presented with a spinal cord tumor exhibiting prominent granular cell-like features, complicating the initial diagnosis.
Gestational Choriocarcinoma With Inferior Vena Cava Tumor Thrombus Formation.
A 52-year-old woman presented with recurrent nausea and vomiting, leading to the discovery of elevated serum β-hCG levels and a pelvic mass extending into the inferior vena cava (IVC).
A Novel De Novo MTM1 Insertion Frameshift Variant Causes X-Linked Myotubular Myopathy in a Chinese Female.
A 24-year-old woman presented with infantile hypotonia and progressive, asymmetric proximal weakness, including facial and ocular involvement.
Tumor Profile, Clinical Features, and Outcomes in Individuals With Constitutional Trisomy 8: A Systematic Review of Case Reports and Case Series.
Constitutional trisomy 8 mosaicism (CT8M) is a rare chromosomal disorder with poorly characterized cancer risk. This systematic review aimed at summarizing reported cases of malignancy and associated clinical outcomes…
A Case of Primary Intramedullary Infantile Fibrosarcoma With an RBPMS::NTRK3 Fusion and Response to Larotrectinib.
A 4-week-old infant presented with rapidly progressive cervical myelopathy due to primary intramedullary infantile fibrosarcoma.
Disseminated Bartonella or Post-Transplant Lymphoproliferative Disease in Pediatric Transplant Patients: A Diagnostic Challenge.
A pediatric kidney transplant patient presented with fever, lymphadenopathy, nausea, vomiting, and abdominal pain. An extensive workup for post-transplant lymphoproliferative disease (PTLD) was initiated, including PET…
Histological Analysis Shows That a Moisturizer Formulated for Dermatoporosis Increases Elastin Content and Improves Skin Elasticity.
This multicenter clinical trial evaluated the effects of a novel moisturizer (GC cream) on skin biomarkers in individuals aged 40 to 60 with dermatoporosis.
A double-blind multi-centre randomised placebo-controlled trial of doxycycline in women with recurrent miscarriage and chronic endometritis defined by CD138 positive stromal cells.
This multicenter, double-blind, randomized controlled trial evaluated the effect of preconceptual doxycycline on live birth rates in women with recurrent miscarriage and chronic endometritis defined by CD138 positive…
Calcitonin-negative 'MTC-like' thyroid paraganglioma revealing an SDHD-related hereditary paraganglioma syndrome: functional confirmation of a non-canonical splice-site variant.
A 36-year-old woman presented with a 20-mm thyroid nodule classified as EU-TIRADS 4 and Bethesda III, with normal serum calcitonin levels.
Oral peri-implant tissue as a neoplastic bed: a systematic review of clinicopathology, pathogenesis, and survival outcomes.
This systematic review assessed the clinicopathology, associated factors, and survival outcomes of histologically confirmed neoplasms adjacent to dental implants.
Exceptional and Durable Response to Selpercatinib in a Patient with Apparently RET -Negative, HRAS -, and NF1 -Mutated Metastatic Medullary Thyroid Carcinoma.
A 50-year-old woman presented with rapidly progressive medullary thyroid carcinoma (Ki-67 30%) and extensive liver and bone metastases.
September 20266
Impact of EBV status and histology on patient outcomes with nivolumab-AVD vs BV-AVD in advanced classic Hodgkin lymphoma (S1826).
This phase 3 randomized controlled trial evaluated the impact of EBV status and histology on outcomes in patients with advanced classic Hodgkin lymphoma treated with nivolumab-AVD (N-AVD) versus brentuximab vedotin-AVD…
Sex-Discordant Monochorionic Dizygotic Twins After Double Blastocyst Transfer: Blood Chimerism Demonstrated by Multimodal Genetic Testing.
A 38-year-old woman conceived through intracytoplasmic sperm injection and double blastocyst transfer, leading to monochorionic diamniotic twins. At 21 weeks, discordant external genitalia were noted.
Metastasis of Invasive Ductal Carcinoma of the Breast to the Uterine Cervix 30 Years Post-Mastectomy: A Case Report.
A 69-year-old woman, 30 years post-mastectomy for invasive ductal carcinoma, presented with abnormal cervical cytology. Imaging revealed a 38-mm cervical mass, leading to a modified radical hysterectomy.
When seizure control comes at a cost: valproic acid-induced necrotising pancreatitis in a patient receiving antiepileptic polypharmacy.
A man in his late 20s with psychiatric and metabolic comorbidities developed acute necrotising pancreatitis while on antiepileptic polypharmacy, including valproic acid.
Metastatic melanoma presenting with paraneoplastic dermatomyositis mimicking polymyalgia rheumatica.
A man in his late 70s presented with bilateral shoulder and hip girdle pain, morning stiffness, and significant weight loss over six weeks.
Lipomatous pseudohypertrophy of pancreas with chronic calcific pancreatitis presenting with nutritional dermatosis and type 3c diabetes.
A woman in her early 50s presented with erythema, scaling of the limbs, weight loss, anasarca, and chronic foul-smelling diarrhea, indicative of nutritional dermatosis due to malabsorption.
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