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1999 articles
September 202624
Efficacy of pancreatic enzyme replacement therapy on exocrine pancreatic insufficiency: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the efficacy of pancreatic enzyme replacement therapy (PERT) in improving nutrient absorption in patients with exocrine pancreatic insufficiency (EPI).
Percutaneous catheter drainage versus needle aspiration for liver abscess: a systematic review and meta-analysis of efficacy and safety.
This systematic review and meta-analysis evaluated the efficacy and safety of percutaneous catheter drainage (PCD) versus needle aspiration (PNA) for liver abscesses in 1425 adults.
A meta-analysis of transjugular intrahepatic portosystemic shunt with or without embolization for esophageal and gastric variceal bleeding in decompensated liver cirrhosis.
This meta-analysis evaluated the efficacy of transjugular intrahepatic portosystemic shunt (TIPS) with or without embolization in 3079 patients with decompensated liver cirrhosis experiencing esophageal and gastric…
A phase 1/1b study of the all-oral regimen CC-486 and venetoclax in acute myeloid leukemia.
This phase 1/1b study evaluated the all-oral regimen of CC-486 and venetoclax in patients with relapsed, refractory, and newly diagnosed acute myeloid leukemia (AML).
Intracardiac vs. transesophageal echocardiography in patients undergoing ablation for atrial fibrillation: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the safety and efficacy of intracardiac echocardiography (ICE) versus transesophageal echocardiography (TEE) in 7671 patients undergoing catheter ablation for atrial…
Impact of EBV status and histology on patient outcomes with nivolumab-AVD vs BV-AVD in advanced classic Hodgkin lymphoma (S1826).
This phase 3 randomized controlled trial evaluated the impact of EBV status and histology on outcomes in patients with advanced classic Hodgkin lymphoma treated with nivolumab-AVD (N-AVD) versus brentuximab vedotin-AVD…
Does a Simple Touch Make a Difference? The Effect of Acupressure on Pain Scores in Infants Undergoing Cardiac Catheterization: A Randomized, Placebo-Controlled Trial.
This randomized, placebo-controlled trial evaluated acupressure in 60 infants aged 1–12 months with congenital heart disease undergoing cardiac catheterization.
Effectiveness of psychosocial counselling on treatment adherence among patients with a new tuberculosis diagnosis in primary care: a study protocol for a cluster-randomised controlled trial.
This study protocol outlines a cluster-randomised controlled trial aimed at evaluating the effectiveness of psychosocial counselling on treatment adherence among newly diagnosed tuberculosis patients in primary care…
Efficacy and safety of tegoprazan-amoxicillin dual therapy versus bismuth-containing quadruple therapy for first-line Helicobacter pylori eradication: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the efficacy and safety of 14-day tegoprazan-amoxicillin dual therapy versus bismuth-containing quadruple therapy (BQT) for first-line Helicobacter pylori eradication…
Imaging biomarkers for cardiometabolic risk stratification in metabolic dysfunction-associated steatotic liver disease: incremental value of coronary artery calcification, epicardial adipose tissue, controlled attenuation parameter, and liver stiffness measurement beyond clinical scores.
This systematic review analyzed 16 observational studies involving 34,713 adults with metabolic dysfunction-associated steatotic liver disease (MASLD) to evaluate the association between MASLD and imaging biomarkers of…
Effect of early regional anesthesia on postoperative cognitive function and the perioperative stress response in patients with hip fractures: a randomized controlled trial.
This randomized controlled trial investigated the effect of anterior iliopsoas muscle space block (AIMSB) timing on postoperative delirium (POD) in 79 elderly patients undergoing total hip arthroplasty for fractures.
Coffee consumption and head and neck cancer risk: a dose-response and site-specific meta-analysis.
This meta-analysis examined the relationship between coffee consumption and head and neck cancer (HNC) risk across 30 studies.
Age and antiplatelet de-escalation after myocardial infarction in the TALOS-AMI trial.
This secondary analysis of the TALOS-AMI randomized trial evaluated the effects of de-escalating from ticagrelor to clopidogrel on clinical outcomes in patients after myocardial infarction, stratified by age.
Lower HLA-B27 positivity and heterogeneous late-onset case proportions across axial spondyloarthritis cohorts: a systematic review and meta-analysis.
This systematic review and meta-analysis examined late-onset ankylosing spondylitis (AS) and axial spondyloarthritis (axSpA) in clinical cohorts, focusing on cases with onset at or after age 45.
Safety and efficacy of human gingiva-derived mesenchymal stem cells in patients with type 1 diabetes: a double-blind, randomized, placebo-controlled, phase 1 trial.
This phase 1 double-blind, randomized, placebo-controlled trial evaluated the safety and efficacy of human gingiva-derived mesenchymal stem cells (GMSCs) in 18 patients with type 1 diabetes mellitus (T1DM).
Genetic Analysis and Reproductive Intervention in a Duchenne Muscular Dystrophy Family With Cryptic Complex Chromosomal Rearrangement Identified by Structural Variation Sequencing.
Duchenne/Becker muscular dystrophy (DMD/BMD) is caused by variants in the X-linked DMD gene-most commonly deletions, duplications, or point mutations, and only rarely by complex chromosomal rearrangements (CCRs).
Continuous Intravenous Acyclovir as Outpatient Parenteral Antimicrobial Therapy for HSV and VZV Neurological Infections: A Case Series With Pharmacokinetic and Cost Evaluation, and Review of Literature.
This case series involved eight patients with neurological infections caused by HSV or VZV who transitioned to continuous intravenous acyclovir via an outpatient parenteral antimicrobial therapy (OPAT) program after…
Does baseline physical function modify the response to a physical activity intervention in adults with arthritis? A secondary analysis of a randomized trial.
This secondary analysis of a randomized controlled trial examined whether baseline physical function influenced the response to a telephone-delivered Walk With Ease (WWE-T) intervention in 267 adults with arthritis.
Severe upper limb soft tissue infection with compartment syndrome following a scratch injury: a case report.
A 58-year-old female teacher developed a severe soft tissue infection in her left arm following a minor scratch from a student.
When two rare diseases meet: atypical hemolytic uremic syndrome and alkaptonuria in two siblings.
Two brothers from a consanguineous family presented with recurrent episodes of atypical hemolytic uremic syndrome (aHUS) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury.
A community-based participatory research and community health workers-led health education strategy for schistosomiasis control among schoolchildren in Pemba Island, Zanzibar: a cluster-randomized trial.
This cluster-randomized controlled trial evaluated a community-based participatory research (CBPR) approach led by community health workers for schistosomiasis control among schoolchildren in Pemba, Zanzibar.
8 weeks versus 12 weeks of sofosbuvir-velpatasvir for treatment-naive, non-cirrhotic, chronic hepatitis C (RESOLVE): a multicentre, open-label, non-inferiority, randomised controlled trial in India.
The RESOLVE multicentre, open-label, randomised non-inferiority trial compared 8 versus 12 weeks of daily sofosbuvir-velpatasvir in treatment-naive adults with chronic hepatitis C without cirrhosis at five publicly…
16S rRNA Datasets of Gut Microbiota in Stent-Based Diverting Technique and Ileostomy from A Prospective, Open-Label, Multicenter Randomized Controlled Trial.
This study presents a 16S rRNA amplicon dataset from a multicenter randomized controlled trial involving 80 patients undergoing either a stent-based diverting technique (SDT) or ileostomy after rectal cancer surgery.
Cardiovascular safety of orforglipron versus insulin glargine in adults with type 2 diabetes at increased cardiovascular risk (ACHIEVE-4): a phase 3, event-driven, randomised, open-label, non-inferiority, active comparator trial.
ACHIEVE-4 was a phase 3, event-driven, multicentre, randomised, open-label, active-comparator non-inferiority trial comparing once-daily oral orforglipron with titrated insulin glargine in adults with type 2 diabetes…
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