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434 articles
September 20268
Mepolizumab efficacy in chronic obstructive pulmonary disease: insights from longitudinal patterns of blood eosinophil counts and their variability across 3 clinical trials.
This randomized controlled trial pooled data from three phase 3 trials to assess the efficacy of mepolizumab in patients with chronic obstructive pulmonary disease (COPD) and varying blood eosinophil counts (BEC).
Dupilumab in chronic obstructive pulmonary disease: a pooled analysis of emergency department visits, hospital admissions, and systemic corticosteroid use.
This pooled analysis from two phase III randomized controlled trials evaluated the impact of dupilumab on emergency department visits, hospital admissions, and systemic corticosteroid use in patients aged 40-85 with…
Astegolimab for chronic obstructive pulmonary disease with frequent exacerbations: pooled analysis of the ALIENTO and ARNASA trials.
This pooled analysis of the ALIENTO and ARNASA trials evaluated the efficacy of astegolimab, an anti-ST2 monoclonal antibody, in patients with chronic obstructive pulmonary disease (COPD) experiencing frequent…
Natural course of untreated obstructive sleep apnea in adults with coronary artery disease in the RICCADSA cohort.
This randomized controlled trial examined the natural course of untreated obstructive sleep apnea (OSA) in 119 adults with coronary artery disease (CAD) after revascularization.
A Rare Case of Sporadic Lymphangioleiomyomatosis in a Male Patient Diagnosed Following Pneumothorax.
A 51-year-old male presented with pneumothorax, leading to the diagnosis of sporadic lymphangioleiomyomatosis (LAM). High-resolution CT scans revealed multiple thin-walled cysts in both lungs.
Low-dose vs standard-dose nintedanib at initiation in fibrosing interstitial lung disease: a target-trial emulation of treatment persistence and lung function.
This observational study emulated a randomized trial to compare the effects of initiating nintedanib at 100 mg vs 150 mg twice daily in 172 patients with fibrosing interstitial lung disease.
Safety and efficacy of elexacaftor/tezacaftor/ivacaftor in adolescents and adults with cystic fibrosis and F508del-gating and F508del-residual function genotypes: results from an open-label extension study.
This phase 3 open-label extension study evaluated the long-term safety and efficacy of elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) in 251 adolescents and adults with cystic fibrosis and F508del-gating or…
Genomic Profiling of Epidermal Growth Factor Receptor Mutation-Positive Non-Small Cell Lung Cancer after Progression on First-line Osimertinib: Phase II ORCHARD Study.
The ORCHARD Phase II study investigated the genomic profiles of patients with EGFR mutation-positive non-small cell lung cancer (NSCLC) after progression on first-line osimertinib.
August 202616
Use of NxStage VersiHD for Frequent Home Hemodialysis in a Hospital Setting: A New Opportunity for Complex Patients.
A non-transportable patient with anasarca and acute kidney injury was treated with the NxStage VersiHD system in a pulmonology ward.
Association of tirzepatide with changes in OSA-related measures based on baseline characteristics - post hoc analyses of SURMOUNT-OSA.
This post hoc analysis of two Phase 3 randomized controlled trials evaluated the effects of tirzepatide on obstructive sleep apnea (OSA) measures in adults with moderate-to-severe OSA and obesity.
Randomised controlled trial to assess the safety and efficiency of a self-contained sampling device/disposable bronchoscope system versus usual sampling procedure (RASECAL).
This multicenter randomized controlled trial evaluated the safety and efficiency of a closed bronchoscopy sampling system (Ambu bronchosampler) compared to standard sampling containers in 188 mechanically ventilated…
Proton pump inhibitors in invasively ventilated patients with SARS-CoV-2: a substudy of the re-evaluating the inhibition of stress erosions trial.
This substudy of the REVISE trial evaluated the effects of pantoprazole in 532 mechanically ventilated patients with SARS-CoV-2.
Intrapulmonary percussive ventilation for the management of destroyed lung in Swyer-James-MacLeod syndrome.
A man in his 60s with a history of childhood pneumonia was diagnosed with bronchiectasis due to Swyer-James-MacLeod syndrome, complicated by chronic Pseudomonas aeruginosa infection.
Impact of patient positioning on the efficacy and safety of doxycycline pleurodesis in malignant pleural effusion: a pilot randomized trial.
This pilot randomized trial evaluated the efficacy and safety of doxycycline pleurodesis in 40 patients with malignant pleural effusion, comparing a standard rotation protocol to a non-rotation approach.
Bivalent RSV Prefusion F Vaccine to Prevent Hospitalizations in Adults.
This randomized controlled trial evaluated the bivalent RSV prefusion F (RSVpreF) vaccine's effectiveness in preventing RSV-related hospitalizations among adults in Denmark and Spain.
Reporting of harms associated with CPAP use in randomised controlled trials: a systematic review.
This systematic review evaluated the reporting of adverse events (AEs) associated with CPAP therapy in randomized controlled trials published from 2009 to 2023, involving 8232 participants.
Acetazolamide mitigates opioid-associated sleep-disordered breathing.
This randomized controlled trial investigated the effects of oral acetazolamide on sleep-disordered breathing (SDB) in nine adults with opioid-associated SDB.
Effectiveness of probiotic supplements in managing pulmonary function and inflammatory status in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effects of probiotic supplementation on pulmonary function and inflammatory markers in patients with chronic obstructive pulmonary disease (COPD).
Kratom-Associated Pulmonary Toxicity: A Systematic Review of Case Reports and Forensic Series with a Proposed Clinical Phenotype Classification.
Kratom use has increased, including concentrated 7-hydroxymitragynine products, but pulmonary toxicity has not been systematically synthesized.
Mitochondrial antioxidant therapy fails to improve obese asthma outcomes.
This 12-week, randomized, double-masked, placebo-controlled trial tested mitochondrial-targeted antioxidant MitoQ in adults with obesity and poorly controlled asthma.
Effect of protective ventilation throughout the intubation period on perioperative oxygenation in patients undergoing MIDCABG: a randomised controlled trial.
This randomized controlled trial evaluated the effects of protective lung ventilation (PLV) during intubation on perioperative oxygenation in 60 patients undergoing minimally invasive direct coronary artery bypass…
Quadriceps muscle behavior assessed by ultrasound in septic patients: A systematic review.
This systematic review examined the use of ultrasound to assess quadriceps muscle atrophy in adults with sepsis or septic shock in ICUs.
Risk of post-acute symptoms and conditions after SARS-CoV-2 compared with other respiratory viral infections: a systematic review and meta-analysis.
This systematic review and meta-analysis compared persistent symptoms and conditions in adults after SARS-CoV-2 infection with those following other acute respiratory viral infections.
Umbilical Cord-Derived Cell-Based Interventions for Bronchopulmonary Dysplasia and Related Complications in Preterm Infants: A Bayesian Sparse-Data Meta-Analysis.
This meta-analysis evaluated umbilical cord-derived cell-based interventions for bronchopulmonary dysplasia (BPD) in preterm infants.
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