Trending archive
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30 articles
October 20265
Approach to the patient with APS-1/APECED.
This article presents five cases of autoimmune polyendocrine syndrome type 1 (APS-1/APECED), a disorder caused by impaired immune tolerance and typically associated with biallelic AIRE variants.
Food-Associated Kounis Syndrome: Clinical Spectrum and Diagnostic Considerations from a Case Report and Systematic Qualitative Synthesis of Published Cases.
The supplied abstract does not describe an individual patient’s presentation, diagnostic findings, or outcome. It reports a qualitative synthesis of published food-associated Kounis syndrome cases: 53 patients across 50…
Adult-Onset Henoch-Schönlein Purpura Triggered by Isotretinoin with Persistent Polyarthritis and Isolated Cutaneous-Gastrointestinal Involvement: A Case Report.
A 30-year-old woman developed palpable purpura, abdominal pain, and symmetric polyarthritis three weeks after starting isotretinoin.
Anaphylaxis Following Intravenous Methylprednisolone Sodium Succinate: A Case Report.
A 45-year-old woman with rheumatoid arthritis developed generalized pruritic erythema and raised lesions, dyspnea, hypoxemia, bradycardia, and reduced consciousness within 5 minutes of starting intravenous…
Suspected allergic bronchopulmonary candidiasis in a patient with concurrent multidrug-resistant bacterial pneumonia: A case report.
A 70-year-old man with a history of hypertension and cerebral infarction presented with sudden right limb weakness and was diagnosed with hemorrhagic cerebral infarction.
September 20269
Mild Phenotype in Functionally Validated STAT1 Gain-of-Function Disease Due to a Novel DNA-Binding Variant.
A case report describes four patients with STAT1 gain-of-function disease, focusing on three related individuals with a novel p.Leu400Pro variant.
Anaphylaxis to both pegfilgrastim and sargramostim in a patient with diffuse large B-cell lymphoma.
A woman in her early 60s with stage 3A diffuse large B-cell lymphoma experienced anaphylaxis to pegfilgrastim after her first cycle of R-CHOP chemotherapy, presenting with syncope and severe hypotension.
Complicated allergic fungal rhinosinusitis: diagnostic complexities and management strategies.
A man in his 60s presented with diplopia, headache, and facial numbness, leading to a diagnosis of bilateral abducens nerve palsy and partial right third nerve palsy.
Novel TRAC variant causing autosomal recessive TCR-alpha/beta deficient immunodeficiency 7.
Monozygotic twin brothers presented in early infancy with severe, recurrent diarrhoea and profound T-cell lymphopenia. Immunological assessment revealed significantly reduced immunoglobulins and very low CD3+, CD4+, and…
Déjà vu.
A male in his mid-20s presented with fever, purpuric rash, neuropathy, marked eosinophilia, hepatic dysfunction, and extensive multisystem thrombosis.
Levocetirizine-induced paradoxical fixed drug eruption: A case report with causality assessment.
A patient developed a fixed drug eruption (FDE) after self-medicating with levocetirizine, presenting with hyperpigmented patches that progressed to blisters.
Recurrent severe cutaneous reaction to fluoroquinolones and rifampicin in a human immunodeficiency virus-positive patient with disseminated tuberculosis: A rare case report.
A 47-year-old male with HIV and disseminated tuberculosis experienced recurrent maculopapular eruptions with mucosal involvement after exposure to multiple medications, including fluoroquinolones and rifampicin.
Chronic autoimmune urticaria with worsening during the luteal phase suggestive of progesterone hypersensitivity successfully treated with rituximab.
A 30-year-old woman with glucocorticoid-dependent chronic spontaneous urticaria (CSU) presented with cyclical worsening of symptoms during her luteal phase.
Suspected menopause nutraceutical-induced eosinophilic ascites: a rare clinical presentation.
A middle-aged woman presented with a 2-month history of ascites and marked peripheral eosinophilia (49%). Analysis of her ascitic fluid revealed 90% eosinophils, with no malignancy detected.
August 20262
A novel FLNA p.Pro2469Ser variant is associated with impaired T and NK cell function and immune dysregulation.
FLNA encodes filamin A, a ubiquitously expressed actin-binding cytoskeletal protein that cross-links actin filaments and links them to membrane-associated signaling complexes.
Long-term outcomes of anti-CD19 CAR T cell therapy in refractory myasthenia gravis: A case series.
Three patients with severe, treatment-resistant myasthenia gravis (MG) were treated with autologous anti-CD19 CAR T cell therapy.
July 20263
Allergic contact dermatitis after laser-assisted photodynamic therapy with 5-aminolevulinic acid: evidence of cross-sensitization to methyl aminolevulinate.
A 67-year-old male developed severe eczematous dermatitis after laser-assisted photodynamic therapy using 5-aminolevulinic acid for actinic keratoses.
Recreational Allergic Contact Dermatitis to "Epoxy UV" Resins: A New Source of Exposure to Hidden (Meth)acrylates.
Three people developed eczematous eruptions after using products labelled “epoxy UV” resin to make jewellery. Patch testing showed sensitization to (meth)acrylates, but not to the epoxy compounds tested.
Marked IgE elevation and eosinophilia in a COPD patient ultimately diagnosed with mycobacterium intracellulare pulmonary disease.
A 65-year-old man with COPD presented with persistent eosinophilia and significantly elevated total IgE levels. Initial evaluations for allergic diseases were negative.
June 20264
A novel JAK1 mutation identified in a patient with severe atopic dermatitis phenotype: Mechanistic insights and IL-4Rα targeted therapy.
A child with early-onset severe atopic dermatitis presented with eosinophilia, elevated IgE, and growth retardation. Genetic analysis identified a novel JAK1 gain-of-function mutation (p.L783F).
Alpha-Gal Syndrome-A Case Series of Successful Transcatheter Mammalian-Derived Aortic Valve Replacements.
Three patients with documented Alpha-gal syndrome (AGS) successfully underwent transcatheter aortic valve replacement (TAVR) using bovine or porcine-derived bioprosthetic valves.
Pediatric Neuroinflammatory and Neuropsychiatric Syndromes Associated with Dupilumab Treatment for Atopic Dermatitis.
Four children treated with dupilumab for atopic dermatitis developed neuroinflammatory syndromes characterized by behavioral changes, language impairment, and neurodiagnostic abnormalities within 2-6 months of starting…
Safety and Early Immune Dynamics Following First Dose of the MMR Vaccine in a Toddler Treated With a JAK Inhibitor.
A toddler receiving baricitinib was accidentally given the live measles-mumps-rubella (MMR) vaccine. No vaccine-related adverse events were reported.
May 20261
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