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63 articles
October 20267
Local Delivery of Interferon-β1a for Respiratory Viral Infections: A Systematic Review.
This PRISMA-guided systematic review assessed locally delivered intranasal or inhaled interferon-β1a for respiratory viral infections, covering clinical trials and experimental evidence.
Metal Hypersensitivity Reactions Following Spinal Implants: A Systematic Review.
This systematic review examined clinical presentation, diagnostic approaches, and outcomes of metal hypersensitivity after spinal implant surgery in adults.
Paediatric Helicobacter pylori infection and allergic and inflammatory diseases: a contemporary systematic review with meta-analysis.
This systematic review and meta-analysis assessed recent evidence on Helicobacter pylori infection and allergic or immune-mediated diseases in children.
Efficacy and safety of subcutaneous efgartigimod with prednisone in moderate-to-severe pemphigus (ADDRESS): a global, phase III, randomised controlled, double-blind trial.
ADDRESS was a global, phase III, multicentre, randomised, double-blind, placebo-controlled trial of adults with newly diagnosed or relapsing moderate-to-severe pemphigus.
Serum Virus-Neutralizing Antibody Titers in Clinical Trial Participants With and Without Immunocompromise Receiving Pemivibart, a Long-Acting Monoclonal Antibody for COVID-19.
This analysis of phase 3 CANOPY and phase 1 trial data examined measured and calculated serum virus-neutralizing antibody titers after pemivibart in participants with and without significant immunocompromise.
Oral deucrictibant for on-demand treatment of hereditary angioedema attacks: a phase 3, multicentre, randomised, double-blind, placebo-controlled crossover trial.
RAPIDe-3 was a phase 3, multicentre, randomised, double-blind, placebo-controlled crossover trial of oral deucrictibant for on-demand treatment of hereditary angioedema attacks.
Treatment of Multifood Allergy With Omalizumab or Multiallergen Oral Immunotherapy: A Randomized Clinical Trial.
This randomized clinical trial compared the efficacy of omalizumab versus multiallergen oral immunotherapy (MOIT) in treating multifood allergies in participants aged 1 to 55 years.
September 202610
Short-term nasal decongestant as bridge therapy with intranasal corticosteroids in children with persistent allergic rhinitis: A randomized controlled trial.
This prospective, open-label, single-centre randomised trial compared intranasal corticosteroid (INS) alone with INS plus five days of oxymetazoline in children aged 4–17 years with moderate-to-severe persistent…
Asthma Intervention with Residential Ventilation and Air Cleaner (AIRVAC) Study: A 4-arm parallel-group randomized controlled trial protocol.
The AIRVAC study is a 4-arm parallel-group randomized controlled trial evaluating the long-term effectiveness of energy recovery ventilators and portable air cleaners in improving asthma outcomes among children and…
Levels of IgG subclasses 1-4 in BT595, a 10% IVIG: A sub-analysis of a clinical trial.
This multicenter, open-label clinical trial evaluated the pharmacokinetics of IgG subclasses in patients with primary immunodeficiency receiving 10% IVIG BT595.
Prenatal maternal stress and the risk of allergic rhinitis in offspring: A systematic review and meta-analysis.
This systematic review and meta-analysis examined whether maternal stress during pregnancy is associated with allergic rhinitis (AR) in offspring. It pooled findings from 9 studies involving 40,630 participants.
Trial of a Maternal Diet Rich in Eggs and Peanuts to Reduce Infant Allergy.
This multicenter randomized controlled trial investigated the effect of a maternal diet rich in eggs and peanuts on the development of food allergies in infants.
IL-2 mutein selectively expands thymic memory Tregs with increased transendocytosis in healthy participants.
This randomized, single-ascending-dose trial in healthy human participants examined how the IL-2 mutein MK-6194 affects regulatory T-cell (Treg) subsets and function.
Effect of repeated exposure to an identical multi-user virtual reality anaphylaxis scenario on paramedic trainee performance: a randomized controlled trial.
This randomized controlled trial evaluated the impact of repeated exposure to a virtual reality (VR) anaphylaxis scenario on the performance of 125 paramedic trainees.
Epidemic Thunderstorm Asthma in China: A Systematic Review of an Artemisia-Associated Phenotype.
This systematic review examines epidemic thunderstorm asthma (ETSA) in China, focusing on its association with Artemisia pollen.
Pharmacokinetic and Pharmacodynamic Bio-Similarity of ADL-018 to Innovator Omalizumab: A Randomized Study in Healthy Adults.
This randomized controlled trial evaluated the pharmacokinetic and pharmacodynamic bio-similarity of ADL-018, a biosimilar to omalizumab, in 306 healthy adults.
Asthma Exacerbation Risk and School Asthma Readiness.
This randomized controlled trial evaluated school asthma readiness and its association with asthma exacerbations in a cohort of 202 children aged 5 to 13 years, predominantly Black and non-Hispanic.
August 20264
Symptom burden to characterise, predict, and prevent asthma attacks: a patient-level meta-analysis of randomised trials and translational prospective studies.
This patient-level meta-analysis evaluated the prognostic value of symptom burden, measured by the ACQ-5, in predicting severe asthma attacks among 7161 participants from various studies.
A multiple ascending dose, phase1b study to evaluate safety, tolerability, pharmacokinetics, and pharmacodynamics of lesigercept, a long-acting IgE Trap -Fc fusion protein, in participants with atopy or allergic diseases.
This phase 1b randomized controlled trial evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of lesigercept in adults with atopy or allergic diseases.
Immunomodulatory effects of palm-derived tocotrienol-rich fraction in healthy volunteers following influenza vaccination: A randomised clinical trial.
This randomized controlled trial evaluated the immunomodulatory effects of palm-derived tocotrienol-rich fraction (TRF) on the immune response to influenza vaccination in 150 healthy adults.
Efficacy and safety of nasal saline irrigation for allergic rhinitis in children and adolescents: A systematic review and meta-analysis with GRADE assessment.
This systematic review and meta-analysis evaluated the efficacy and safety of nasal saline irrigation (NSI) for allergic rhinitis in children and adolescents.
July 20263
Epitope-specific IgE profiles are predictive of desensitization and remission in the IMPACT trial.
The IMPACT trial, a randomized controlled trial, evaluated the predictive value of epitope-specific IgE profiles for desensitization and remission in children undergoing peanut oral immunotherapy (pnOIT).
Efficacy and safety of press-needle therapy for allergic rhinitis in children: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the efficacy and safety of press-needle therapy for allergic rhinitis in children, analyzing 24 randomized controlled trials with 1625 participants.
Defining Minimal Clinical Disease Activity and Remission in Severe Asthma: A Modified Delphi Consensus.
This systematic literature review and modified Delphi consensus sought to standardize definitions of minimal clinical disease activity and remission in severe asthma.
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