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96 articles
October 202624
Molecular-genetic mechanisms of cerebral arteriovenous malformations: A systematic review of germline, somatic and experimental evidence.
This systematic review synthesised human genetic, molecular, and experimental evidence on cerebral arteriovenous malformation (AVM) formation, clinical course, and potential therapeutic targets.
Translational applications and clinical utility of organoids in ovarian cancer: a systematic review.
This systematic review synthesized 13 studies of patient-derived organoids (PDOs) in ovarian cancer, assessing feasibility, histological fidelity, and agreement between organoid drug sensitivity and clinical outcomes.
Baseline Serum Metabolites as Predictors of Teplizumab Response in Individuals With Type 1 Diabetes.
This analysis examined whether baseline serum metabolites could predict response to teplizumab in 41 people newly diagnosed with type 1 diabetes who participated in the randomized AbATE trial.
Ciliated hepatic foregut cyst in children and adolescents: a systematic review of clinical presentation, diagnosis, management, and outcomes.
This PRISMA 2020 systematic review descriptively synthesised case reports and case series of histopathologically confirmed ciliated hepatic foregut cysts in patients aged 19 years or younger.
SOX10 Expression in Primary Salivary Gland Tumors: A Meta-Analysis.
This PRISMA-guided systematic review and meta-analysis assessed SOX10 immunohistochemical expression across primary salivary gland tumors. It included 35 studies comprising 1146 histological and 35 cytological samples.
Impact of Phosphatidylinositol 3-Kinase and B-Raf Mutations in Rat Sarcoma Wild-Type Metastatic Colorectal Cancer.
This systematic review and meta-analysis assessed whether PIK3CA and BRAF mutations were associated with outcomes among patients with RAS wild-type metastatic colorectal cancer receiving first-line EGFR inhibitor…
Primary Hepatic Neuroendocrine Neoplasms: Systematic Review and Expert Pathologist Reappraisal Using the WHO 6th Edition Framework.
Primary hepatic neuroendocrine neoplasms (PHNENs) are exceedingly rare. Published evidence often lacks adequate clinicopathological support for a primary hepatic origin and uses inconsistent historical terminology.
Prognostic value of measuring LSC frequency in AML: a systematic review and meta-analysis.
This systematic review and reconstructed individual patient data meta-analysis assessed whether leukemia stem cell (LSC) measurements predict outcomes in patients with acute myeloid leukemia at diagnosis or in…
Dynamics of QuantiFERON-TB Gold Plus Results in a Large TB Preventive Treatment Trial Across 3 High-Burden HIV/TB Countries.
This longitudinal analysis of a randomized trial assessed serial QuantiFERON-TB Gold Plus (QFT-Plus) results in people with HIV enrolled in Ethiopia, Mozambique, and South Africa and assigned to three TB preventive…
Phase I Trial of IL13Rα2-Targeted CAR T-cell Therapy for Recurrent Malignant Glioma: Clinical Results and Pharmacokinetics.
This single-centre, open-label phase I trial assessed intravenous autologous IL13Rα2-targeted CAR T cells in adults with recurrent, IL13Rα2-expressing grade 3–4 gliomas after standard treatment.
AI-Based Pathology Classifier Predicts Sensitivity to Enzalutamide in Metastatic Hormone-Sensitive Prostate Cancer: A Biomarker Analysis of the ENZAMET Trial.
This prespecified biomarker analysis of the randomised ENZAMET trial assessed whether a locked artificial intelligence pathology image classifier (APIC) identified differential overall-survival benefit from enzalutamide…
Multimodal assessment of exceptional responders refines subtyping-directed precision treatment in HR+/HER2- breast cancer.
This clinical-trial analysis examined whether multimodal tumour and clinical features could clarify exceptional responses to subtype-directed treatment in locally advanced HR+/HER2− breast cancer.
Fibro-Inflammatory Signaling, Fibrosis, and Microvascular Ischemia as Convergent Translational Substrates of Sudden Cardiac Death in Hypertrophic Cardiomyopathy: A Systematic Review.
This systematic translational review examined whether fibro-inflammatory signaling, fibrosis, and microvascular ischemia converge as substrates for ventricular arrhythmia and sudden cardiac death in hypertrophic…
Cold and Room-Temperature Platelets in Cardiac Surgery: The CHIPS Randomized Clinical Trial.
The phase 3, multicenter, randomized CHIPS trial compared cold-stored platelets (CSPs; up to 21 days) with room-temperature platelets (RTPs; up to 7 days) in pediatric and adult patients receiving platelet transfusions…
Application of a concise video to improve patient understanding of tumor genomic testing in community and academic practice settings.
This multicenter clinical trial evaluated a 3–4 minute educational video for patients undergoing standard-of-care tumor genomic testing (TGT), across cancer types and academic and community settings.
Association of virulence genes with biofilm formation in clinical Enterococcus faecalis isolates: a systematic review and meta-analysis.
This systematic review and random-effects meta-analysis assessed associations between virulence gene carriage and microplate-measured biofilm formation in human clinical Enterococcus faecalis isolates.
Near point-of-care nucleic acid amplification tests (NPOC-NAATs) using respiratory specimens for detection of pulmonary tuberculosis.
This Cochrane systematic review and meta-analysis assessed near point-of-care nucleic acid amplification testing for pulmonary tuberculosis in adults, adolescents, and children with presumptive disease.
Astrocytic and Axonal Injury Biomarkers in AQP4 Antibody-Positive NMOSD: Insights From PREVENT and CHAMPION-NMOSD.
This biomarker analysis used samples from the phase 3 PREVENT and CHAMPION-NMOSD trials to assess serum GFAP and NfL in people with AQP4 antibody-positive NMOSD receiving eculizumab or ravulizumab.
Immunohistochemistry for c-MET, HLA class II, and CD68 does not show prognostic value in early-stage classic Hodgkin lymphoma patients in the EORTC-GELA H9 intergroup randomised trial.
This case-cohort biomarker validation study examined whether immunohistochemical expression of c-MET, HLA class II, or CD68 predicted progression-free survival in patients with early-stage classic Hodgkin lymphoma…
Artificial intelligence-powered renal pathology for glomerular disease classification: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the performance of artificial intelligence (AI) models in classifying glomerular diseases using pathology images.
Concordance of Microbiological and Histopathological Examination of Bone Biopsies in Diagnosing Diabetic Foot Osteomyelitis, a Systematic Review.
This systematic review evaluated the diagnostic concordance of histopathology and microbiology in bone biopsies from 308 adults with diabetic foot osteomyelitis (DFO).
The impact of intratumor heterogeneity on outcome and resistance to therapy in primary breast cancer: a systematic review.
This systematic review examines the impact of intratumor heterogeneity (ITH) on chemotherapy resistance in primary breast cancer, analyzing 12 studies across various tumor subtypes.
Trial-specific absolute disease-free survival effects of postoperative PD-1/PD-L1 blockade after complete resection of NSCLC: A systematic review.
This systematic review estimated absolute disease-free survival (DFS) effects of postoperative single-agent PD-1/PD-L1 blockade after complete resection of non-small-cell lung cancer.
Tumor-Free Circulating Tumor DNA in Node-Negative Rectal Cancers Undergoing Neoadjuvant Chemotherapy, Excision, and Observation in the Phase II NEO Trial (CO.28).
The Phase II NEO trial investigated the role of circulating tumor DNA (ctDNA) in guiding treatment decisions for 53 patients with node-negative rectal cancer undergoing neoadjuvant chemotherapy and transanal excision.
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