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1999 articles
September 202624
Genetic Analysis and Reproductive Intervention in a Duchenne Muscular Dystrophy Family With Cryptic Complex Chromosomal Rearrangement Identified by Structural Variation Sequencing.
Duchenne/Becker muscular dystrophy (DMD/BMD) is caused by variants in the X-linked DMD gene-most commonly deletions, duplications, or point mutations, and only rarely by complex chromosomal rearrangements (CCRs).
Continuous Intravenous Acyclovir as Outpatient Parenteral Antimicrobial Therapy for HSV and VZV Neurological Infections: A Case Series With Pharmacokinetic and Cost Evaluation, and Review of Literature.
This case series involved eight patients with neurological infections caused by HSV or VZV who transitioned to continuous intravenous acyclovir via an outpatient parenteral antimicrobial therapy (OPAT) program after…
Sex differences in the efficacy, acceptability, and tolerability of antipsychotics in people with acute schizophrenia: individual participant data pairwise, dose-response, and network meta-analyses.
This individual participant data pairwise, dose-response, and network meta-analysis examined sex differences in antipsychotic efficacy, acceptability, and tolerability in adults with acute schizophrenia.
More than meets the eye: A meta-analysis of visual outcomes following clipping, coiling, and flow diversion for visually symptomatic paraclinoid aneurysms.
This PRISMA-compliant systematic review and random-effects meta-analysis compared visual outcomes after clipping, coiling, and flow diversion for paraclinoid aneurysms, drawing on 21 studies.
Clinical, economic, and quality-of-life outcomes of brexucabtagene autoleucel for the treatment of relapsed/refractory mantle cell lymphoma and B-cell acute lymphoblastic leukemia: A systematic literature review and meta-analysis.
This systematic literature review and meta-analysis evaluated the clinical, healthcare resource use, and quality-of-life outcomes of brexucabtagene autoleucel in adults with relapsed/refractory mantle cell lymphoma…
Positive Syphilis Serology With Concurrent Disseminated Talaromycosis marneffei in a Patient With HIV: A Case Report.
A 37-year-old male with HIV presented with a rash and was initially diagnosed with secondary syphilis based on positive serology. After ampicillin treatment failed to improve his condition, he developed fever and cough.
Open versus closed suctioning on lung volume and oxygenation in ARDS patients with PEEP 5-10 cmH2O: A randomized controlled trial.
This randomized controlled trial compared open suctioning (OS) and closed suctioning (CS) in 60 ARDS patients on mechanical ventilation with PEEP 5-10 cmH2O.
Lower HLA-B27 positivity and heterogeneous late-onset case proportions across axial spondyloarthritis cohorts: a systematic review and meta-analysis.
This systematic review and meta-analysis examined late-onset ankylosing spondylitis (AS) and axial spondyloarthritis (axSpA) in clinical cohorts, focusing on cases with onset at or after age 45.
First systematic mapping of non-target [68Ga]Ga-DOTANOC uptake across anatomical sites and etiologies.
This systematic review analyzed 76 studies involving 542 patients to map non-target [68Ga]Ga-DOTANOC uptake across various anatomical sites and etiologies.
Age and antiplatelet de-escalation after myocardial infarction in the TALOS-AMI trial.
This secondary analysis of the TALOS-AMI randomized trial evaluated the effects of de-escalating from ticagrelor to clopidogrel on clinical outcomes in patients after myocardial infarction, stratified by age.
Endoscopic Ultrasound-Guided Hepaticogastrostomy With Plastic Stent Versus Metallic Stent for Malignant Biliary Obstruction: A Meta-Analysis.
This meta-analysis evaluated the efficacy and safety of plastic versus metal stents in endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) for malignant biliary obstruction.
Doing the groundwork at home, working through it together: patient experiences of blended cognitive therapy for PTSD in routine care.
This qualitative study explored patient experiences with blended trauma-focused cognitive therapy (bTF-CT) for PTSD in routine care, involving 11 participants.
The association between disability and mortality among children and adolescents: A systematic review and meta-analysis.
This systematic review and meta-analysis examined all-cause mortality among children and adolescents with disabilities compared to non-disabled peers, analyzing 29 studies with over 35 million participants.
Urinary dipstick findings and UTI risk with SGLT2 inhibitors: a post-hoc analysis of the CANVAS and CREDENCE trials.
This post-hoc analysis of the CANVAS and CREDENCE trials evaluated the relationship between urinary dipstick findings and UTI risk in 8614 participants with type 2 diabetes.
Isolated clival Langerhans cell histiocytosis in a pediatric patient: systematic review and illustrative case report.
A 3.5-year-old boy presented with isolated clival Langerhans cell histiocytosis, confirmed through histopathological and immunohistochemical evaluation.
Implementing a medical opinion leader-led management model to promote timely treatment initiation among screen-positive patients with upper gastrointestinal cancer in rural China: a cluster randomised controlled trial protocol.
This cluster randomised controlled trial aims to assess the effectiveness of a medical opinion leader-led management model in reducing treatment initiation time for screen-positive upper gastrointestinal cancer patients…
Treatment of Seven Severely Atrophic Maxillary Full-Arch Cases Using Digitally Planned and Produced Immediately Loaded Screw-Retained Subperiosteal Implants: A Case Series with Surgical and Initial Prosthetic Outcomes.
This case series details the treatment of seven patients with severely atrophic maxillae using digitally planned and custom-milled subperiosteal implants.
Transverse infundibulotomy for resection of a right ventricular outflow tract myxoma.
A 25-year-old asymptomatic 64 kg female with an incidental heart murmur was found, on echocardiography, to have a 2 cm echogenic mass beneath the pulmonary valve, with a peak gradient of 11 mmHg and mild pulmonic…
Cardiac intimal sarcoma presenting with pseudo-pulmonary embolism: surgical debulking, RVOT reconstruction and pulmonary valve replacement.
A 27-year-old woman presented with dyspnoea and signs of right-heart failure following delivery. Initial imaging suggested pulmonary embolism, prompting emergency surgery due to haemodynamic instability.
Oral anticoagulant monotherapy versus oral anticoagulant plus antiplatelet therapy in adults with stable coronary artery disease.
This is a protocol for a Cochrane review (intervention). The objectives are as follows: To assess the benefits and harms of oral anticoagulant monotherapy compared with oral anticoagulant plus antiplatelet therapy in…
Laparoscopic Treatment of Zinner Syndrome: A Case Report.
A 36-year-old man presented with infertility and chronic pelvic pain, diagnosed with Zinner syndrome, which included left renal agenesis, ureteral atresia, and a large seminal vesicle cyst.
Non-paraneoplastic Autoimmune Cerebellar Ataxia with Sensory Ataxia Associated with the Anti-Ca/ARHGAP26 Antibody: A Case Report.
A man in his 50s presented with one month of subacute, progressive gait instability, exhibiting both cerebellar and deep-sensory ataxia.
Comparative Effectiveness and Safety of FOLFOXIRI Plus Cetuximab Versus FOLFOXIRI Plus Bevacizumab in Metastatic Colorectal Cancer: A GRADE-assessed Systematic Review and Meta-analysis.
This systematic review and meta-analysis evaluated the effectiveness and safety of FOLFOXIRI plus cetuximab versus FOLFOXIRI plus bevacizumab in 561 patients with metastatic colorectal cancer (mCRC).
Operative treatment of high-grade medial collateral ligament injury and chronic medial knee instability: a systematic review.
This systematic review assessed the operative treatment of high-grade medial collateral ligament (MCL) injuries and chronic medial knee instability, focusing on clinical phenotype rather than MCL grade.
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