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1999 articles
September 202624
Petrelintide, a human amylin analogue for the treatment of obesity (ZUPREME 1): a randomised, double-blind, placebo-controlled, phase 2 trial.
This multicentre, randomised, double-blind, placebo-controlled phase 2 trial assessed once-weekly petrelintide in adults with obesity or overweight with hypertension or dyslipidaemia, without type 2 diabetes.
GLP-1 receptor agonist exposure in the periconceptional period and adverse obstetric outcomes: A systematic review and meta-analysis.
This systematic review and random-effects meta-analysis examined observational studies comparing pregnancies with and without GLP-1 receptor agonist exposure during pregnancy or within six months before a positive…
Subcutaneous infliximab for maintenance therapy in children and adolescents with inflammatory bowel disease: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effectiveness and safety of subcutaneous infliximab for maintenance therapy in children and adolescents with inflammatory bowel disease.
Designing Youth Early Intervention in Psychosis Services: A Secondary Framework Synthesis of Organisational Recommendations.
This systematic review synthesized organizational recommendations from 26 international guidelines on early intervention in psychosis (EIP) for youth.
Continuous Versus Routine EEG in Critically Ill Patients Without Primary Neurologic Condition: Analysis of a Randomized Controlled Trial.
This post hoc analysis of the multicenter randomized CERTA trial evaluated the effectiveness of continuous EEG (cEEG) versus routine EEG (rEEG) in critically ill patients without primary neurologic conditions.
Long-term clinical outcomes of stem cell-based interventions in Crohn's-related perianal fistula: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the long-term outcomes of stem cell-based interventions for Crohn's disease-related perianal fistulas in 750 patients.
The effects of dual-task training with different task priorities on physical performance and cognitive status in patients with Parkinson's disease: a single-blind, randomized controlled trial.
This randomized controlled trial investigated the effects of variable-priority dual-task training (V-DTT) and fixed-priority dual-task training (F-DTT) on physical performance and cognitive status in 30 patients with…
Prophylactic Immediate Lymphatic Reconstruction for the Prevention of Secondary Lymphedema: A Systematic Review and Meta-Analysis of Comparative Studies.
This systematic review and meta-analysis evaluated the effectiveness of prophylactic lymphovenous shunting (LVS) in preventing secondary lymphedema in 2261 patients undergoing axillary and inguinal lymph node…
The Effect of Oropharyngeal Colostrum Administration on Early Feeding Skills and Transition to Oral Feeding in Preterm Infants: A Randomized Controlled Trial.
This randomized controlled trial investigated the impact of oropharyngeal colostrum administration on oral feeding readiness in 60 preterm infants (26 0 to 33 6/7 weeks gestation).
Recurrent serotonin syndrome during low-dose venlafaxine treatment in a patient with reduced CYP2D6 activity.
A man in his late 70s with transthyretin amyloidosis experienced recurrent serotonin syndrome while on low-dose venlafaxine treatment.
The FIRE technique - A tube ligation alternative.
A patient undergoing glaucoma surgery with a nonvalved glaucoma drainage device (GDD) was treated using the Flanged Intraluminal Ripcord Element (FIRE) technique.
Sarcopenia in Indian adults with type 2 diabetes: a systematic review and meta-analysis of prevalence and associated factors.
This systematic review and meta-analysis assessed the prevalence of sarcopenia among Indian adults with type 2 diabetes mellitus (T2DM).
Heart rate variability suppression in cancer patients versus non-cancer controls: a systematic review and meta-analysis.
This systematic review and meta-analysis examined heart rate variability (HRV) in cancer patients compared to non-cancer controls, including 28 studies with 3232 participants.
Retatrutide in adults with obesity and type 2 diabetes (TRIUMPH-2): a double-blind, parallel-group, randomised, placebo-controlled, phase 3 trial.
TRIUMPH-2 was a double-blind, parallel-group, randomised, placebo-controlled phase 3 trial at 92 centres in eight countries. It assessed once-weekly retatrutide in adults with obesity and type 2 diabetes.
Segmental sternal resection for metastatic ovarian cancer: surgical technique and clinical outcome.
Isolated sternal recurrence from ovarian cancer is exceptionally rare, and its optimal surgical management remains poorly defined.
Epigenetic Programming of Stress-Response Systems: A Systematic Review of How Early Life Stress Shapes Developmental Trajectories of Mental Health.
This systematic review examines how early life stress (ELS) influences mental health development through epigenetic mechanisms, particularly DNA methylation, in 14 empirical human studies.
Lacosamide effects on pain management in patients with multiple sclerosis: A randomized, double-blind, placebo-controlled clinical trial.
This randomized, double-blind, placebo-controlled trial assessed lacosamide for moderate-to-severe MS-related pain in adults with definite multiple sclerosis.
Genital lichen sclerosus with complete introital obliteration presenting with chronic urinary retention.
A postmenopausal woman with hypothyroidism presented with chronic urinary retention caused by complete introital obliteration due to lichen sclerosus.
Oral glucose solution for the treatment of persistent asymptomatic neonatal hypoglycemia: a randomized, double-blind, placebo-controlled trial.
This multicenter, randomized, double-blind, placebo-controlled trial evaluated the efficacy of buccal 50% dextrose solution (D50W) in treating persistent asymptomatic hypoglycemia in at-risk late preterm and term…
A Case Report to Explore A Wrong-Site Surgery Error.
A case of wrong-site surgery involved an incorrect nerve block performed during a nonemergent orthopedic procedure. Despite some verification steps being completed, the incident was attributed to lapses in established…
Hypofractionated versus conventional fractionated postmastectomy radiotherapy for patients with high-risk breast cancer (CHN HYPOPMRT): 10-year outcomes from a randomised, non-inferiority, open-label, phase 3 trial.
This phase 3 randomized trial compared hypofractionated (43.5 Gy in 15 fractions) and conventional (50 Gy in 25 fractions) postmastectomy radiotherapy in 810 women with high-risk breast cancer.
Exploring treatment moderators in a randomized clinical trial of virtual reality-based vs. standard cognitive behavioral therapy for paranoia.
This randomized clinical trial secondary analysis explored whether clinical and sociodemographic characteristics moderated response to virtual reality-based cognitive behavioral therapy for psychosis (VR-CBTp) versus…
Purely transvenous treatment of cervical paraspinal arteriovenous fistulas.
This report details two patients with paraspinal arteriovenous fistulas (PSAVF) treated using a purely transvenous approach.
Autologous rotational partial thickness scleral flap - A salvage technique for late leaking blebs with scleral fistula.
Two patients with late leaking blebs complicated by scleral fistulae underwent a modified autologous rotational partial-thickness scleral flap procedure.
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