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2000 articles
October 202624
Molecular Profiling of Tisotumab Vedotin-Treated Patients Identifies Immune Pathways Associated with Clinical Activity.
This phase II multicenter trial evaluated the efficacy of tisotumab vedotin (TV) in patients with recurrent or metastatic cervical cancer (r/mCC).
Evaluating CPR Breast Attachment Impact on EMT Training: A Randomized Controlled Trial.
This randomized controlled trial evaluated the impact of the ReviveHer breast attachment on EMT students' willingness and comfort in performing CPR on breasted and nonbreasted individuals.
Oral peri-implant tissue as a neoplastic bed: a systematic review of clinicopathology, pathogenesis, and survival outcomes.
This systematic review assessed the clinicopathology, associated factors, and survival outcomes of histologically confirmed neoplasms adjacent to dental implants.
Systematic Review: Inclusion of Patients With Difficult-to-Treat Inflammatory Bowel Disease in Randomized Controlled Trials of Advanced Therapies.
This systematic review examined how patients with difficult-to-treat inflammatory bowel disease (DTT-IBD) were represented in randomized controlled trials of advanced therapies for ulcerative colitis and Crohn’s…
Durable efficacy and manageable long-term safety of lisocabtagene maraleucel for 3L+ FL: 3-year update from TRANSCEND FL.
The TRANSCEND FL study evaluated the long-term efficacy and safety of lisocabtagene maraleucel (liso-cel) in patients with relapsed/refractory follicular lymphoma (FL) after at least two prior therapies.
How I treat thrombotic microangiopathy in the setting of triggers.
A patient presented with thrombotic microangiopathy during pregnancy, which complicated the diagnosis due to the potential trigger.
Investigation of a Prostate Cancer Radiation Response Signature in the Breast Cancer SweBCG91RT Randomized Trial.
This randomized controlled trial evaluated the Prostate cancer Radiation Therapy Outcomes Score (PORTOS) in predicting radiotherapy benefit in 765 patients with early-stage breast cancer.
First-in-Human, Open-label, Single-Arm Phase I Study of [211At] meta-Astatobenzylguanidine in Patients with Pheochromocytoma or Paraganglioma.
This first-in-human, open-label, single-arm Phase I study evaluated the safety and pharmacokinetics of 211At-meta-astatobenzylguanidine (211At-MABG) in 10 patients with unresectable or metastatic pheochromocytomas or…
A Phase 2, Open-Label, Randomized Controlled Trial Evaluating Safety and Efficacy of Dose-Intensified Versus Standard Dosing Regimens of [ 177 Lu]Lu-PSMA-597 in mCRPC (OPTIMAL-PSMA).
The OPTIMAL-PSMA study is a Phase 2, open-label, randomized controlled trial evaluating the safety and efficacy of a dose-intensified regimen of [177Lu]Lu-PSMA-597 versus standard dosing in 120 patients with metastatic…
Phase I Trial of GPC3-Targeted TCR Fusion Construct, CT0180, in Patients with Advanced Hepatocellular Carcinoma.
This Phase I open-label trial evaluated the safety and preliminary efficacy of CT0180, a GPC3-targeted TCR fusion construct, in patients with advanced hepatocellular carcinoma (HCC) who had progressed on standard…
Clinical Trial Protocol for LPS-Boost: Intensified [ 177 Lu]Lu-PSMA-617 Treatment for Patients with Metastatic Castration-Resistant Prostate Cancer with Low PSMA-Expressing Disease.
This multicenter, open-label phase 2 trial investigates an intensified treatment schedule of [177Lu]Lu-PSMA-617 for 45 patients with metastatic castration-resistant prostate cancer (mCRPC) and low PSMA expression.
Long-Term Safety and Efficacy of Dazukibart in Dermatomyositis: Combined Phase II Results From Double-Blind and Open-Label Extension Studies.
This study evaluated the long-term safety and efficacy of dazukibart, an antiinterferon β monoclonal antibody, in adults with moderate-to-severe dermatomyositis through a combined Phase II randomized controlled trial…
The Use of Deliberate Practice in Simulation-Based Surgical Training for Open General and Subspeciality Surgery: A Systematic Review.
This systematic review evaluates the integration of deliberate practice (DP) in simulation-based surgical training (SBST) for open general and subspecialty surgery.
A Phase I Study of PF-07062119, an Anti-GUCY2C/Anti-CD3 Bispecific Fc Antibody, in Patients with Advanced Gastrointestinal Cancers.
This Phase I multicenter study evaluated PF-07062119, an anti-GUCY2C/anti-CD3 bispecific antibody, in 79 patients with advanced gastrointestinal cancers.
Long-term Follow-up of Third-generation Anti-CD30 CAR T-cell Therapy in Relapsed/Refractory CD30+ Lymphomas: A Single-Arm, Multicenter, Phase I/II Trial.
This single-arm, multicenter, phase I/II trial evaluated long-term outcomes of third-generation anti-CD30 CAR T-cell therapy in 44 patients with relapsed/refractory CD30+ lymphoma.
Exceptional and Durable Response to Selpercatinib in a Patient with Apparently RET -Negative, HRAS -, and NF1 -Mutated Metastatic Medullary Thyroid Carcinoma.
A 50-year-old woman presented with rapidly progressive medullary thyroid carcinoma (Ki-67 30%) and extensive liver and bone metastases.
Utilizing Machine Learning to Identify Multimodal Signatures for Patients Who Would Benefit from the Addition of Tremelimumab to Durvalumab and Chemotherapy (TRIDENT).
The TRIDENT analysis, a post hoc study of the POSEIDON trial, utilized machine learning to identify patients with metastatic non-small cell lung cancer (NSCLC) who may benefit from adding tremelimumab to durvalumab and…
Neuro-linguistic programming for postoperative pain management: A randomized controlled trial.
This randomized controlled trial evaluated the impact of a single neuro-linguistic programming (NLP) session on postoperative pain management in 76 women after cesarean delivery.
Apheresis-Triggered Torsades De Pointes in Congenital Long QT Syndrome Type 2: Citrate-Related Arrhythmia Risk and Safe Modality Switching During Myasthenic Crisis.
A 44-year-old woman with congenital long QT syndrome Type 2 presented in myasthenic crisis due to anti-MuSK-positive myasthenia gravis.
Low-Dose Cytarabine Plus G-CSF Induction in Pediatric M2 Acute Myeloid Leukemia: A Multicenter Study.
This multicenter randomized controlled trial analyzed the efficacy and safety of low-dose chemotherapy (LDC) versus standard-dose chemotherapy (SDC) in 221 children with M2 acute myeloid leukemia.
Age- and sex-specific trends in Canadian mental health from 2003 to 2024: a repeated cross-sectional meta-regression analysis.
This meta-analysis examined trends in mental health outcomes in Canada from 2003 to 2024, using data from the Canadian Community Health Survey.
New Primary and Secondary Prevention Measures for Cutaneous Melanoma: A Systematic Review.
This systematic review evaluated recent evidence on primary and secondary prevention strategies for cutaneous melanoma, analyzing 24 studies.
LigaSure versus conventional excisional haemorrhoidectomy: A systematic review and meta-analysis with trial sequential analysis of randomised controlled trials.
This systematic review and meta-analysis evaluated 43 randomized controlled trials involving 3,277 participants to compare LigaSure with conventional excisional haemorrhoidectomy.
Network meta-analysis of robotic ventral and incisional hernia repair techniques: intraperitoneal, preperitoneal, retromuscular, and sublay approaches.
This network meta-analysis evaluated the efficacy and safety of various robotic ventral and incisional hernia repair techniques in 9,348 adults.
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