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1999 articles

October 202624

Clinical ResearchPlastic Surgery

A Prospective, Multicenter, Evaluator-Blind, Randomized, Comparator-Controlled Study of Belotero Intense (+), a Hyaluronic Acid Filler With Lidocaine, for Lip Augmentation.

This multicenter, evaluator-blind randomized comparator-controlled equivalence trial assessed Belotero Intense with lidocaine (BIL) for lip augmentation in patients with lip volume deficits, comparing it with Restylane…

Aesthet Surg JOct 15, 2026Read summary
Case ReportGeneral Surgery

Micro-layering technique for esthetic rehabilitation. A case report.

A male patient sought esthetic rehabilitation for a diastema between the central incisors, mismatched tooth shapes, and overall dental disharmony.

Int J Esthet DentOct 15, 2026Read case
Clinical ResearchEndocrinology

AI-Driven Lifestyle Interventions for Reducing Diabetes Risk: Systematic Review.

This systematic review assessed AI-driven digital lifestyle interventions for people with prediabetes or elevated diabetes risk, including healthy participants in feasibility studies.

J Med Internet ResOct 15, 2026Read summary
Clinical ResearchPediatrics

The impact of prophylactic azithromycin on the developing preterm gut microbiome and resistome.

This multicentre, double-blind, randomised, placebo-controlled trial examined the effects of 10 days of prophylactic intravenous azithromycin on the gut microbiome and resistome of 693 preterm infants born before 30…

Gut MicrobesOct 15, 2026Read summary
Clinical ResearchMedical Genetics

Safety and efficacy of delpacibart zotadirsen in Duchenne muscular dystrophy mutations amenable to exon 44 skipping in the USA (EXPLORE44): a randomised, placebo-controlled, double-blind, phase 1/2 trial.

EXPLORE44 was a two-part, randomised, double-blind, placebo-controlled phase 1/2 trial at ten US sites, studying delpacibart zotadirsen (del-zota) in healthy adult men and in ambulatory and non-ambulatory males aged…

Lancet NeurolOct 15, 2026Read summary
Clinical ResearchCardiologyOpen access

Immune checkpoint inhibitor-related myocarditis, myositis, and myasthenia gravis overlap syndrome: a single-center case series and systematic review.

The aim of our study was to evaluate the clinical, diagnostic, therapeutic, and prognostic features of immune checkpoint inhibitor-related myocarditis, myositis, and myasthenia gravis overlap syndrome (IM3OS).

Support Care CancerOct 15, 2026Read summary
Clinical ResearchOncology (Medical)

AI-Based Pathology Classifier Predicts Sensitivity to Enzalutamide in Metastatic Hormone-Sensitive Prostate Cancer: A Biomarker Analysis of the ENZAMET Trial.

This prespecified biomarker analysis of the randomised ENZAMET trial assessed whether a locked artificial intelligence pathology image classifier (APIC) identified differential overall-survival benefit from enzalutamide…

Clin Cancer ResOct 15, 2026Read summary
Case ReportVascular Surgery

PERCUTANEOUS MECHANICAL THROMBECTOMY: A NEW TOOL IN THE TREATMENT OF ACUTE MESENTERIC ISCHEMIA.

An 82-year-old woman with atrioventricular block, hypertension, and dementia presented with acute abdominal pain that had begun three days earlier.

Port J Card Thorac Vasc SurgOct 15, 2026Read case
Case ReportEndocrinology

Behind the Sella: A Rare Case of Pituicytoma Mimicking a Pituitary Adenoma.

A 48-year-old man presented with symptoms of hypogonadism, headaches, and visual field defects. Testing showed hypogonadotropic hypogonadism and hyperprolactinemia, while MRI revealed a sellar-suprasellar mass initially…

Am J Case RepOct 15, 2026Read case
Clinical ResearchPediatrics

Bacterial infections and antibiotic susceptibility in children with sickle-cell anemia on malaria chemoprevention using Dihydroartemisinin-piperaquine (DP) or Sulfadoxine-pyrimethamine (SP) in Uganda.

This analysis nested within a randomized, double-blind trial assessed bacterial infections and antimicrobial resistance among Ugandan children aged 6 months to 15 years with sickle-cell anemia receiving weekly…

PLoS OneOct 15, 2026Read summary
Clinical ResearchNeurology

The ability of the commercial inertial measurement unit-based gait system in determining Parkinson's disease: A systematic review with meta-analysis of cross-sectional studies.

This systematic review and meta-analysis of cross-sectional studies assessed whether commercial inertial measurement unit (IMU)-based gait systems distinguish people with Parkinson’s disease (PD) from healthy controls.

PLoS OneOct 15, 2026Read summary
Clinical ResearchInfectious Diseases

Long-Acting HIV Therapy in African Adults with Adherence Challenges.

This phase 3b, open-label, randomized trial compared long-acting injectable cabotegravir plus rilpivirine with daily oral dolutegravir-based therapy in adults in Kenya, South Africa, and Uganda who had suppressed HIV-1…

N Engl J MedOct 15, 2026Read summary
Clinical ResearchOphthalmology

Comparative Efficacy and Safety of Systemic Immunomodulatory Therapies for Non-Infectious Uveitis: A Systematic Review With Pairwise and Network Meta-Analyses.

This systematic review and network meta-analysis compared systemic immunomodulatory therapies for non-infectious uveitis (NIU), including evidence from seven studies with 992 participants: six randomised trials and one…

PharmacotherapyOct 15, 2026Read summary
Clinical ResearchFamily Medicine

Improving Musculoskeletal Care Quality With a Web-Based Clinical Decision Support System in UK Primary Care: Mixed Methods Cluster-Randomized Controlled Trial.

This mixed methods, cluster-randomized controlled trial evaluated CrossCover, a web-based clinical decision support system for adult musculoskeletal consultations in UK general practice.

J Med Internet ResOct 15, 2026Read summary
Clinical ResearchVascular Surgery

The Moderating Effects of Race and Ethnicity on a Motivational Interviewing Intervention for Improving Physical Health Among Patients With Peripheral Artery Disease: Secondary Analysis of a Pilot Randomized Trial.

This secondary analysis of a pilot randomized trial examined whether social determinants of health modified motivational interviewing (MI) effects on walking distance and weight among community-dwelling adults with…

JMIR Form ResOct 15, 2026Read summary
Clinical ResearchCardiology

Coronary microvascular dysfunction in patients undergoing transcatheter aortic valve implantation: A systematic review and meta-analysis.

This systematic review and meta-analysis examined coronary microvascular dysfunction (CMD) in adults with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI).

PLoS OneOct 15, 2026Read summary
Clinical ResearchPsychiatryOpen access

Assessing the Impact of Metacognitive Therapy on OCD Severity and Beliefs: A Three-Wave Multisite RCT With Panel Mediation Analysis.

This multisite, assessor-blinded randomized controlled trial compared 12 weekly sessions of individual metacognitive therapy (MCT) with documented treatment as usual (TAU) in 76 adults with OCD receiving outpatient care…

Depress AnxietyOct 15, 2026Read summary
Clinical ResearchOncology (Medical)

Brigimadlin versus Doxorubicin in Advanced Dedifferentiated Liposarcoma: Efficacy, Safety, and Translational Data from Brightline-1, a Randomized Phase II/III Trial.

Brightline-1 was a randomized phase II/III trial comparing first-line brigimadlin with doxorubicin in patients with MDM2-amplified, locally advanced or metastatic dedifferentiated liposarcoma.

Clin Cancer ResOct 15, 2026Read summary
Clinical ResearchOncology (Medical)Open access

A Phase I Dose-Escalation/Expansion Study of Fractionated-Dose and Multiple-Cycle Anti-PSMA-Targeted α-Emitter 225Ac-J591 in Patients with Prostate Cancer.

This phase I dose-escalation and expansion study evaluated fractionated and repeated-cycle 225Ac-J591 in patients with progressive metastatic prostate cancer resistant to androgen pathway modulation.

Clin Cancer ResOct 15, 2026Read summary
Clinical ResearchGastroenterology

Phase 2 Trial of Icotrokinra for Patients with Ulcerative Colitis.

This phase 2b, double-blind, randomized trial evaluated once-daily oral icotrokinra, an interleukin-23 receptor blocker, in adults with moderately to severely active ulcerative colitis.

N Engl J MedOct 15, 2026Read summary
Clinical ResearchInfectious Diseases

Safety and immunogenicity of a first-generation modified vaccinia virus Ankara-vectored SARS-CoV-2 vaccine candidate with mRNA-based booster vaccination: A phase 1 trial.

This phase 1 trial assessed safety and immune responses to the MVA-vectored SARS-CoV-2 vaccine MVA-SARS-2-S in 30 healthy, SARS-CoV-2-naive adults given two doses 28 days apart, with six-month follow-up.

Hum Vaccin ImmunotherOct 15, 2026Read summary
Clinical ResearchOncology (Medical)

Weight Loss Responses to Pharmacotherapy in Breast Cancer Survivors: Results from the Adaptive Nutrition and Exercise Weight Loss (A-NEW) Study.

This single-arm phase II study evaluated behavioral weight loss (BWL), with Contrave added for women with prior stage 0 to III breast cancer who lost less than 5% of their weight after two months.

Clin Cancer ResOct 15, 2026Read summary
Clinical ResearchObstetrics & Gynecology

Geographic Variation in Diagnostic Performance of Amsel Criteria and Nugent Score for Vaginal Dysbiosis Defined by 16S rRNA Gene Sequencing.

This analysis compared Amsel criteria and Nugent scoring with 16S rRNA sequencing-defined vaginal community state types in screening and follow-up specimens from a Phase 1b randomized trial at sites in South Africa and…

J Infect DisOct 15, 2026Read summary
Clinical ResearchOncology (Medical)Open access

FDA Approval Summary: Erdafitinib for FGFR3-Altered Locally Advanced or Metastatic Urothelial Carcinoma.

This FDA approval summary describes evidence supporting erdafitinib for patients with FGFR3-altered locally advanced or metastatic urothelial carcinoma that progressed during or after at least one systemic therapy.

Clin Cancer ResOct 15, 2026Read summary

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