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2000 articles
October 202623
Opioid Use and Family Members' Experiences of Opioids in Paediatric Cancer Pain Management: An Integrative Review.
This integrative review analyzed opioid use in pediatric cancer pain management and family members' experiences. Sixteen peer-reviewed articles were reviewed, revealing that morphine and fentanyl are the most commonly…
Osimertinib plus Gefitinib in Patients with EGFR-Mutated Advanced Non-Small Cell Lung Cancer and EGFR (C797X) Mutation Following First-Line Osimertinib: ORCHARD.
The ORCHARD study was a phase II trial assessing the efficacy of osimertinib plus gefitinib in patients with EGFR-mutated advanced non-small cell lung cancer (NSCLC) and EGFR C797X mutation after progression on…
Malignant phyllodes tumour with spinal metastasis presenting as cauda equina syndrome.
A female in her early 50s with a history of borderline phyllodes tumour underwent right mastectomy and adjuvant radiotherapy.
Mastectomy and sentinel lymph node biopsy in a patient with left-sided breast cancer and Poland syndrome.
An elderly woman with left-sided Poland syndrome presented with breast cancer detected during routine imaging for malignant melanoma.
Multidisciplinary Treatment With Repeated Thermal Ablation for Multisite Metastatic Colon Cancer in an Elderly Patient.
An 81-year-old woman with a history of myocardial and cerebral infarctions presented with metastatic colon cancer, including multiple liver and ovarian metastases.
First-trimester pregnancy-associated breast cancer managed without pregnancy termination: a report with long-term follow-up.
A patient diagnosed with breast cancer in the first trimester opted to continue her pregnancy rather than terminate it. She underwent total mastectomy and axillary lymph node dissection, with chemotherapy initiated…
From Genomic Insight to Clinical Impact: Dramatic Response in RET Fusion-positive Pancreatic Cancer.
A 48-year-old woman with pancreatic ductal adenocarcinoma and liver metastases experienced a significant response to selpercatinib after genomic profiling revealed an NCOA4-RET fusion.
Pembrolizumab plus Chemotherapy for Synchronous Multiple Primary Esophageal and Gingival Squamous Cell Carcinomas.
A 68-year-old man presented with synchronous squamous cell carcinomas of the esophagus and mandibular gingiva. He received pembrolizumab combined with cisplatin and 5-fluorouracil, leading to a clinical complete…
Well-differentiated SMARCB1-deficient Pancreatic Malignancy With Indolent Liver Metastases.
A 66-year-old woman underwent distal pancreatectomy for a pancreatic tail malignancy, later developing liver metastases six years post-surgery.
Wound dehiscence following biportal endoscopic versus microscopic spine surgery for single-level lumbar decompression: a post hoc analysis of two randomized controlled trials.
This post hoc analysis of two randomized controlled trials compared wound dehiscence rates between biportal endoscopic spine surgery (BESS) and microscopic spine surgery (MSS) in 211 patients undergoing single-level…
Evaluating plasma ferritin and suPAR as treatable traits for critically ill patients with COVID-19 treated with anakinra: an exploratory analysis of the immune modulation domain of the REMAP-CAP randomised clinical trial.
This exploratory analysis of the REMAP-CAP randomized clinical trial evaluated plasma ferritin and suPAR as potential treatable traits for anakinra in critically ill COVID-19 patients.
Alpha-catenin Mutation-associated Synchronous Follicular Thyroid Carcinoma and Papillary Thyroid Carcinoma With Numerous Adenomatoid Nodules.
A 59-year-old woman with a history of breast cancer was found to have a thyroid nodule during a chest CT. Subsequent biopsies revealed synchronous minimally invasive follicular thyroid carcinoma and classic papillary…
Surgical Resection of Metachronous Liver Metastases in Non-colorectal Non-neuroendocrine Gastrointestinal Cancers: Systematic Review and Meta-analysis.
This systematic review and meta-analysis evaluated the impact of surgical resection on overall survival in patients with metachronous liver metastases from non-colorectal non-neuroendocrine gastrointestinal cancers.
Guillain-Barré syndrome temporally associated with respiratory syncytial virus vaccination.
An older woman experienced acute progressive limb weakness, pain, and paraesthesia two weeks post-respiratory syncytial virus vaccination.
Temporary Mesocaval Bypass During Pancreaticoduodenectomy for Pancreatic Cancer With Portal Vein Occlusion: A Case Report.
A 79-year-old man with locally advanced pancreatic cancer and complete portal vein occlusion underwent pancreaticoduodenectomy after showing a favorable response to preoperative therapy.
Clinical Reasoning: A 13-Year-Old Boy With Acute-Onset Generalized Dystonia, Rostrocaudal Gradient, and Severe Bulbar Dysfunction.
A 13-year-old boy presented with acute-onset generalized dystonia, characterized by progressive slowness, speech loss, dysphagia, rigidity, and dystonic posturing over a month.
Pearls & Oy-sters: Diagnosis of Pediatric Tumefactive Multiple Sclerosis With MRI Biomarkers.
A 16-year-old boy presented with subacute headaches, cognitive difficulties, dizziness, blurry vision, right arm weakness, numbness, and gait issues.
Digital Health Technologies for Risk Factor Management and Secondary Prevention After Stroke: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the effectiveness of digital health interventions for managing vascular risk factors in stroke survivors.
Ultrasound-Guided Dorsal Penile Nerve Block Reduces Perioperative Opioid Requirements in Pediatric Circumcision: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the effectiveness of ultrasound-guided versus landmark-based dorsal penile nerve block (DPNB) in reducing opioid requirements during pediatric circumcision.
Updated Meta-Analysis of Left Atrial Appendage Closure Versus Oral Anticoagulation to Prevent Stroke in Atrial Fibrillation.
This systematic review and meta-analysis pooled six randomized controlled trials comparing percutaneous left atrial appendage closure (LAAC) with oral anticoagulation in 7028 patients with nonvalvular atrial…
DDX3Y loss-of-function variant in AZFa-like non-obstructive azoospermia highlights gaps in current Y-chromosome microdeletion testing.
A man with idiopathic non-obstructive azoospermia presented with an AZFa-like phenotype, characterized by elevated FSH and a normal karyotype.
A hypertensive response to irrigation: endoscopic repair of a ventral spinal CSF leak.
A 36-year-old woman with recurrent spontaneous intracranial hypotension due to a ventral T11-12 CSF leak underwent endoscopic repair.
A 6-Year-Old With Becker Muscular Dystrophy and Catatonia.
A 6-year-old boy presented with acute behavioral changes suggestive of catatonia, including altered speech and awareness. He was found to have previously undiagnosed Becker muscular dystrophy.
September 20261
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