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2000 articles

September 202624

Case ReportMedical Genetics

A rare case of hereditary spastic paraplegia with homozygous mutation in the ZFYVE26 gene.

A 19-year-old female with consanguineous parents presented with gait disturbances, lower limb spasticity, and dysarthria. Neurological examination revealed motor and mental retardation, bilateral lower limb spasticity…

Ideggyogy SzSep 29, 2026Read case
Clinical ResearchOncology (Medical)

Efficacy and safety of T-DXd versus Other HER2-targeted therapies in second-line and later settings for HER2-positive metastatic breast cancer: A Bayesian network meta-analysis.

This Bayesian network meta-analysis evaluated the efficacy and safety of T-DXd compared to other HER2-targeted therapies in 3,339 patients with HER2-positive metastatic breast cancer after trastuzumab-based therapy.

PLoS OneSep 29, 2026Read summary
Clinical ResearchGeriatricsOpen access

Dual Sensory Impairment and Depressive Symptoms: Association and Pathways in Three Cohorts and a Meta-Analysis.

This meta-analysis examined the relationship between dual sensory impairment (DSI) and depressive symptoms in three aging cohorts: CHARLS, HRS, and ELSA.

Depress AnxietySep 29, 2026Read summary
Clinical ResearchNeurologyOpen access

Prevalence of Cerebellar Cognitive Affective Syndrome in Patients with Cerebellar Disorders: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis evaluated the prevalence of cerebellar cognitive affective syndrome (CCAS) in patients with cerebellar disorders.

CerebellumSep 29, 2026Read summary
Clinical ResearchNeurology

Systolic blood pressure targets after successful endovascular thrombectomy: a network meta-analysis of randomized controlled trials.

This network meta-analysis evaluated the impact of different systolic blood pressure (SBP) targets on outcomes after endovascular thrombectomy in eight studies.

Neurol SciSep 29, 2026Read summary
Clinical ResearchGastroenterology

A systematic and critical review of measurement scales for evaluating gastrointestinal symptoms during exercise.

This systematic review evaluated 126 studies on measurement scales for gastrointestinal symptoms (GIS) during exercise, focusing on Likert-type and visual analog scales (VAS).

J Int Soc Sports NutrSep 29, 2026Read summary
Case ReportOncology (Medical)

Segmental sternal resection for metastatic ovarian cancer: surgical technique and clinical outcome.

Isolated sternal recurrence from ovarian cancer is exceptionally rare, and its optimal surgical management remains poorly defined.

Multimed Man Cardiothorac SurgSep 29, 2026Read case
Case ReportMedical Genetics

FOXG1 syndrome: genetic background revealed by trio WES in case of a critically ill neonate.

A male neonate presented with hypotonia and abnormal respiratory effort at birth. Due to the serious and non-specific clinical signs, trio whole-exome sequencing (WES) was performed, revealing a de novo heterozygous…

Ideggyogy SzSep 29, 2026Read case
Clinical ResearchObstetrics & Gynecology

GLP-1 receptor agonist exposure in the periconceptional period and adverse obstetric outcomes: A systematic review and meta-analysis.

This systematic review and random-effects meta-analysis examined observational studies comparing pregnancies with and without GLP-1 receptor agonist exposure during pregnancy or within six months before a positive…

MedSep 29, 2026Read summary
Case ReportOncology (Medical)

Combined mastectomy and beating heart coronary artery bypass grafting: a single-session surgical approach.

A woman in her 70s with papillary ductal carcinoma in situ underwent a combined surgical approach due to severe coronary artery disease.

BMJ Case RepSep 29, 2026Read case
Case ReportOrthopedic SurgeryOpen access

Occipitocervical fusion and decompression in Morquio syndrome: a case report and literature review.

A 10-year-old girl with Morquio syndrome presented with progressive quadriparesis due to severe cervical myelopathy. She underwent occipitocervical decompression and fusion, which led to significant neurological…

Childs Nerv SystSep 29, 2026Read case
Clinical ResearchPsychiatry

Acceptability and Feasibility of a Virtual Family-Based Single-Session Intervention for Young Teens at High Risk for Substance Use Disorder: Single-Arm Pilot Trial.

This single-arm pilot trial evaluated a virtual family-based single-session intervention (SSI) for young teens aged 12-14 at high risk for substance use disorder (SUD).

JMIR Form ResSep 29, 2026Read summary
Case ReportCardiology

Total Left Main Occlusion ST-Elevation Myocardial Infarction Complicated by Cardiogenic Shock and Delayed Sinus Node Dysfunction.

A 58-year-old man presented with severe chest pain due to an extensive anterolateral STEMI caused by total occlusion of the left main coronary artery.

Am J Case RepSep 29, 2026Read case
Clinical ResearchNephrology

Blood Pressure Dipping Status in Chronic Kidney Disease and Association With Adverse Outcomes: A Systematic Review and Meta-Analysis.

This systematic review and random-effects meta-analysis examined nondipping blood pressure prevalence, its association with CKD, and outcomes among people with CKD.

J Am Heart AssocSep 29, 2026Read summary
Clinical ResearchCardiology

Incidence and Predictors of Complications After Transcatheter Aortic Valve Implantation According to VARC-3 Criteria: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis pooled 57 studies involving 73 588 patients undergoing transcatheter aortic valve implantation (TAVI), with complications classified using VARC-3 criteria.

J Am Heart AssocSep 29, 2026Read summary
Clinical ResearchOncology (Medical)

Home-based exercise interventions incorporating cardiac rehabilitation principles for people with cancer: a systematic review and meta-analysis.

This systematic review and meta-analysis evaluated home-based exercise interventions incorporating cardiac rehabilitation principles in adults with cancer.

Ann MedSep 29, 2026Read summary
Clinical ResearchCardiology

Sirolimus Versus Paclitaxel Drug-Coated Ballons for Femoropopliteal Disease: The LIMUS FLOW Trial.

The LIMUS FLOW proof-of-concept randomized controlled trial compared sirolimus-coated balloons (SCBs) with paclitaxel-coated balloons (PCBs) for severe femoropopliteal peripheral artery disease in 70 patients.

J Am Heart AssocSep 29, 2026Read summary
Case ReportAnesthesiology

False Passage During Single-Lung Ventilation in a Tracheostomized Patient: Intraoperative Recognition and Rescue.

A 63-year-old man with a recent tracheostomy due to cervical cellulitis underwent urgent thoracotomy for mediastinal debridement.

Am J Case RepSep 28, 2026Read case
Case ReportMedical Genetics

Type A Insulin Resistance Syndrome Due to a Pathogenic Variant in the INSR Gene.

A woman in her 40s, initially diagnosed with type 1 diabetes, presented with a 30-year history of fluctuating insulin sensitivity and later developed insulin resistance, despite being non-obese.

Ir Med JSep 28, 2026Read case
Clinical ResearchRadiology (Diagnostic)

Current Evidence on Periprocedural Flat-Panel CT in Endovascular Stroke Treatment: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis examined periprocedural flat-panel CT (FPCT) findings and clinical applications in patients undergoing endovascular stroke treatment.

StrokeSep 28, 2026Read summary
Clinical ResearchPhysical Medicine & Rehabilitation

Shear wave elastography for assessing lower extremity muscle stiffness after anterior cruciate ligament reconstruction: A systematic review.

This systematic review synthesized studies using shear wave elastography (SWE) to assess lower-extremity muscle stiffness after anterior cruciate ligament reconstruction (ACLR), comparing reconstructed limbs with…

Clin Biomech (Bristol)Sep 28, 2026Read summary
Clinical ResearchGastroenterology

Evaluation of a Mental Health Care App-Based Fatigue Management Program for Patients With Inflammatory Bowel Disease in Remission: Protocol for a Randomized Controlled Trial.

This randomized controlled trial aims to evaluate a mobile cognitive behavioral intervention for fatigue management in patients with inflammatory bowel disease (IBD) in remission.

JMIR Res ProtocSep 28, 2026Read summary
Case ReportOphthalmology

Non-Arteritic Anterior Ischaemic Optic Neuropathy Associated with Semaglutide use.

A woman in her 70s with vascular risk factors presented with a three-day history of progressive left-sided visual disturbance. Examination revealed a left relative afferent pupillary defect and inferior quadrantopia.

Ir Med JSep 28, 2026Read case
Clinical ResearchNeurosurgeryOpen access

Pain outcomes and safety in trigeminal neuralgia: a systematic review and meta-analysis comparing percutaneous balloon compression with microvascular decompression.

This systematic review and meta-analysis evaluated the efficacy and safety of percutaneous balloon compression (PBC) versus microvascular decompression (MVD) in treating trigeminal neuralgia (TN) among 1284 patients.

Neurosurg RevSep 28, 2026Read summary

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