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2000 articles
September 202624
Sacituzumab tirumotecan in previously treated metastatic triple-negative breast cancer: a detailed safety analysis of the randomized OptiTROP-Breast01 study.
This randomized controlled trial analyzed the safety profile of sacituzumab tirumotecan (sac-TMT) in 262 patients with previously treated metastatic triple-negative breast cancer.
Localised cutaneous leishmaniasis in an immunosuppressed host: the role for adjuvant photodynamic therapy after incomplete amphotericin B response.
An immunocompromised man in his 70s presented with a 15-year verrucous plaque on the right hallux, initially misdiagnosed as squamous cell carcinoma.
Treat-to-target strategies for low-density lipoprotein cholesterol and triglyceride levels for primary and secondary prevention of cardiovascular disease in adults with dyslipidaemia.
This Cochrane systematic review protocol aims to assess the effectiveness of treat-to-target strategies for managing low-density lipoprotein cholesterol and triglyceride levels in adults with dyslipidaemia.
Delayed cardiac conduction disease in a young adult following childhood Chagas infection.
A Bolivian man in his 30s presented to the emergency department with non-exertional chest pain and intermittent second-degree atrioventricular block.
Autologous Hematopoietic Transplantation Reduces Brain Inflammatory and Axoglial Damage Biomarkers in Multiple Sclerosis.
This Phase II multicenter clinical trial investigated the effects of autologous hematopoietic stem cell transplantation (AHSCT) on inflammatory and axoglial damage biomarkers in 24 patients with severe multiple…
Prevalence and risk factors for road traffic accidents and mortalities in the Amhara region, Ethiopia: a systematic review and meta-analysis.
This systematic review and meta-analysis examined the prevalence and risk factors of road traffic accidents in the Amhara region of Ethiopia, analyzing data from 12 studies involving 5,222 participants.
Intraoperative positioning strategies to improve stone-free outcomes during retrograde intrarenal surgery: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the impact of intraoperative positioning strategies on stone-free outcomes during retrograde intrarenal surgery (RIRS) for renal calculi, involving 998 patients across…
Phytate and L-methionine for preventing recurrence of infection renal stones.
This report details a series of cases where patients with recurrent infection renal stones and brushite stones were treated with a combination of phytate and L-methionine.
Effects of natriuresis-guided diuretic therapy in men and women with acute heart failure: insights from PUSH-AHF.
This exploratory sex-specific analysis of the multicentre randomised PUSH-AHF trial examined natriuresis-guided diuretic therapy versus standard care in 310 patients with acute heart failure, 45% of whom were women.
Adherence to medical management of kidney stones: A systematic review.
This systematic review evaluated adherence to AUA guidelines for kidney stone management in adults, analyzing 35 studies with 57,970 patients.
Evaluating the Clinical Utility of TSPO-PET in MS and the Influence of Methodological Heterogeneity: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated TSPO-PET imaging in multiple sclerosis (MS) patients compared to healthy controls.
Changes in renal function in patients with chronic kidney disease after ureteroscopy: a systematic review and meta-analysis from EAU endourology.
This systematic review and meta-analysis evaluated changes in estimated glomerular filtration rate (eGFR) after ureteroscopy (URS) or retrograde intrarenal surgery (RIRS) in patients with chronic kidney disease (CKD).
Metastatic dedifferentiated malignant melanoma with spindle cell morphology.
A man in his early 60s presented with a slow-growing skin lesion on his back, which had been present for two decades, and a newly noticed right axillary mass.
Crohn's disease unmasks pulmonary sarcoidosis on biologic screening: dual granulomatous pathology responsive to infliximab.
A man in his 30s with a history of ileal Crohn's disease was diagnosed with pulmonary sarcoidosis during routine pre-biologic screening, despite being asymptomatic.
Unlocking the airway through mandibular distraction followed by TMJ release in bilateral TMJ ankylosis complicated by severe OSA.
An early adolescent with bilateral TMJ ankylosis presented with severe obstructive sleep apnoea (OSA), facial asymmetry, and a limited mouth opening of 2 mm.
Reversible bilateral cerebellar ataxia resulting from hypercapnic encephalopathy in an undiagnosed patient with obstructive sleep apnoea.
A man in his 40s with morbid obesity and type 2 diabetes presented with early-morning drowsiness and respiratory distress after nocturnal dyspnoea and diuretic use.
Responder analysis of adaptive postural balance cardiac rehabilitation exercise in patients with coronary artery disease and type 2 diabetes: secondary analysis of a randomized trial.
This secondary analysis of a randomized trial evaluated the effects of adaptive postural balance cardiac rehabilitation exercise (APBCRE) versus aerobic exercise (AE) in 167 patients with coronary artery disease and…
Systemic and intracranial activity of antibody-drug conjugates in patients with non-small cell lung cancer and brain metastases: A systematic review and meta-analysis.
This systematic review and meta-analysis assessed systemic and intracranial responses to antibody-drug conjugates (ADCs) in patients with non-small cell lung cancer and brain metastases.
Nine-year ocular developmental outcomes after ranibizumab or laser treatment for zone II retinopathy of prematurity: follow-up of a randomized trial cohort.
This study followed a randomized trial cohort to assess 9-year ocular developmental outcomes in children treated with intravitreal ranibizumab (IVR) or laser photocoagulation (LP) for zone II retinopathy of prematurity…
Multicentre randomised controlled trial protocol in China comparing postless hip arthroscopy with conventional perineal post-assisted hip arthroscopy to reduce perineal complications in patients undergoing hip arthroscopy for femoroacetabular impingement: the POSTLESS-HIP trial.
The POSTLESS-HIP trial is a multicentre, prospective, parallel-group, randomised controlled trial in China evaluating postless hip arthroscopy versus conventional perineal post-assisted hip arthroscopy in 270 patients…
Second-Line Systemic Therapy Following First-Line FOLFIRINOX or NALIRIFOX in Metastatic Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated second-line therapies following first-line FOLFIRINOX or NALIRIFOX in 3888 adults with metastatic pancreatic ductal adenocarcinoma.
Endovascular Treatment for Patients Aged ≥80 Years with Large Ischemic Stroke.
This randomized controlled trial evaluated the effectiveness and safety of endovascular treatment (EVT) in patients aged ≥80 years with large ischemic stroke.
Efficacy of a needle-free blood collection device (PIVO Pro) for avoiding contaminated blood culture sets in Australian emergency departments: protocol for an adaptive group sequential randomised controlled trial.
This study protocol outlines a multicentre, adaptive group sequential randomised controlled trial aimed at evaluating the efficacy of the needle-free blood collection device, PIVO Pro, in reducing blood culture…
Effects of Ciprofol- versus Remimazolam-Based Total Intravenous Anesthesia on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy: A Randomized Controlled Trial.
Postoperative nausea and vomiting (PONV) remains common after laparoscopic cholecystectomy. Whether ciprofol-based anesthesia reduces PONV compared with remimazolam-based anesthesia remains unclear.
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