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2000 articles

October 202624

Clinical ResearchCardiology

Intravascular imaging guidance in complex PCI: a meta-analysis of randomized trials across complex lesion subsets.

This meta-analysis pooled randomized trials comparing intravascular imaging (IVI)-guided with angiography-guided PCI in patients with trial-defined complex PCI or extractable complex-lesion cohorts.

Int J CardiolOct 8, 2026Read summary
Clinical ResearchRheumatology

Evaluation of EVT401, a P2X7 receptor antagonist, in healthy Chinese participants: a first-in-human, double-blind, randomized, placebo-controlled, dose-escalation trial.

This phase I, randomized, double-blind, placebo-controlled dose-escalation trial evaluated oral EVT401, a P2X7 receptor antagonist, in healthy Chinese participants aged 18 to 50 years.

Eur J PharmacolOct 8, 2026Read summary
Clinical ResearchEmergency Medicine

Determinants of unwitnessed out-of-hospital cardiac arrest: a systematic review (HL-D-26-00618).

This systematic review synthesized observational studies of demographic, socioeconomic, clinical, and situational factors associated with witnessed status among adults with out-of-hospital cardiac arrest (OHCA).

Heart LungOct 8, 2026Read summary
Case ReportGeneral Surgery

Perioperative Nursing Care of a Patient With 70% TBSA Second- To Third-Degree Flame Burns Complicated by Pseudomonas aeruginosa Infection: A Case Report.

A patient with 70% TBSA second- to third-degree flame burns developed a Pseudomonas aeruginosa infection and required surgical care, including back debridement.

Nurs Crit CareOct 8, 2026Read case
Clinical ResearchPsychiatry

Estimating the Economic Value of Supported Online Parent-Led Cognitive Behavioral Therapy to Prevent Child Anxiety Problems: Economic Evaluation of the MYCATS Cluster Randomized Controlled Trial.

This economic evaluation alongside the MYCATS parallel-group, superiority cluster randomised trial assessed supported online parent-led cognitive behavioural therapy (OSI+TS) plus usual school practice versus usual…

J Med Internet ResOct 8, 2026Read summary
Case ReportAnesthesiologyOpen access

Ilioinguinal-Transversus Abdominis Plane (I-TAP) Block with Liposomal Bupivacaine for Analgesia After Cesarean Delivery: A Randomized Controlled Trial.

Cesarean delivery is frequently associated with suboptimal postoperative analgesia. While PROSPECT guidelines recommend transversus abdominis plane (TAP) block for post-cesarean analgesia, conventional TAP block may…

Drug Des Devel TherOct 8, 2026Read case
Clinical ResearchAllergy & Immunology

Oral deucrictibant for on-demand treatment of hereditary angioedema attacks: a phase 3, multicentre, randomised, double-blind, placebo-controlled crossover trial.

RAPIDe-3 was a phase 3, multicentre, randomised, double-blind, placebo-controlled crossover trial of oral deucrictibant for on-demand treatment of hereditary angioedema attacks.

LancetOct 8, 2026Read summary
Clinical ResearchOncology (Medical)

The role of physical activity in oral cancer recovery: a systematic review.

This systematic review examined physical activity and recovery-related outcomes among people living with or beyond oral cancer. It included 24 studies spanning randomised trials, pilot trials, and cohort studies.

Phys TherOct 8, 2026Read summary
Case ReportOncology (Medical)

Histologically Confirmed Brain Metastasis Arising From Giant Cell Tumor of Bone: an Uncommon Entity and a Challenging Condition.

A 39-year-old patient with no significant medical history had a giant cell tumor of bone (GCTB) in the left distal femur, treated with preoperative denosumab and resection with prosthetic reconstruction.

Am J Case RepOct 8, 2026Read case
Case ReportPediatrics

68Ga-DOTATATE PET/CT Detection of Hypertrophic Osteoarthropathy in a Pediatric Patient With Neuroblastoma Following Anti-GD2 Immunotherapy.

A 5-year-old boy with high-risk neuroblastoma underwent 68Ga-DOTATATE PET/CT to assess response after anti-GD2 immunotherapy.

Clin Nucl MedOct 8, 2026Read case
Case ReportMedical Genetics

A Lynch syndrome patient with multiple cancers who was found to have a novel pathogenic variant generating aberrant splicing of MLH1.

A Japanese woman with colorectal, gastric, and endometrial cancers was found to carry the germline MLH1 variant c.545G>T (p.Arg182Met), initially classified by a clinical testing laboratory as a variant of uncertain…

Jpn J Clin OncolOct 8, 2026Read case
Clinical ResearchOncology (Medical)

A multicenter randomized phase III trial of weekly cisplatin chemoradiotherapy versus radiotherapy in elderly patients with head and neck squamous cell carcinoma unfit for high-dose cisplatin: JCOG2405 (ELDER-WEEKLY).

JCOG2405 (ELDER-WEEKLY) is a planned multicenter, randomized phase III trial comparing radiotherapy plus weekly cisplatin (40 mg/m2) with radiotherapy alone in patients aged ≥70 years with locally advanced head and neck…

Jpn J Clin OncolOct 8, 2026Read summary
Clinical ResearchNeurology

Intracerebral stimulation inducing emotions in SEEG: a systematic review.

This systematic review examined subjective emotional responses to direct intracerebral stimulation during SEEG, synthesizing 34 publications (21 cohort studies and 13 clinical cases) involving 2434 patients and 14,492…

NeuroimageOct 8, 2026Read summary
Clinical ResearchPediatricsOpen access

Age-adjusted shock index vs. reverse shock index multiplied by Glasgow Coma Scale to evaluate mortality in pediatric trauma: a systematic literature review and meta-analysis.

This systematic review and meta-analysis compared the age-adjusted Shock Index (SIPA) with reverse Shock Index multiplied by Glasgow Coma Scale variants (rSIG/rSIM) for predicting outcomes in trauma patients younger…

Pediatr Surg IntOct 8, 2026Read summary
Clinical ResearchCardiologyOpen access

Efficacy and safety of PCSK9 inhibitors combined with statins in acute ischemic stroke: a systematic review and meta-analysis.

This systematic review and meta-analysis of randomized controlled trials compared PCSK9 inhibitors plus statins with statins alone in patients with acute ischemic stroke.

J NeurolOct 8, 2026Read summary
Case ReportInfectious DiseasesOpen access

Phaeohyphomycosis in a Solid Organ Transplant Recipient: Case Report of a New Pathogenic Species of Kirschsteiniothelia.

A 63-year-old immunocompromised recipient of a combined heart-lung transplant developed a subcutaneous thigh lesion. Surgical debridement and histopathology indicated a deep fungal infection.

MycopathologiaOct 8, 2026Read case
Case ReportInfectious DiseasesOpen access

Varicella zoster virus meningitis with a dermatomal rash in immunocompetent hosts: a systematic review and novel case report.

A 44-year-old immunocompetent man presented with fever, severe headache, and a right-sided vesicular rash in the C4-C5 dermatomes. He was initially misdiagnosed with a tick-borne illness.

J NeurovirolOct 8, 2026Read case
Clinical ResearchNeurologyOpen access

Multimodal MRI markers of white matter hyperintensities and their impact on cognition in cerebral small vessel disease: a systematic review.

This systematic review examined associations between multimodal MRI markers of white matter hyperintensities (WMH) and cognition in adults with cerebral small vessel disease.

Brain Imaging BehavOct 8, 2026Read summary
Case ReportInfectious Diseases

Tularemia Takes a Tropical Turn: A Rare Case of Typhoidal Tularemia in Florida.

A 36-year-old man in Florida with no significant medical history or recent travel had six months of fevers, malaise, rigors, fatigue, night sweats, and unintentional 30-pound weight loss.

Am J Case RepOct 8, 2026Read case
Clinical ResearchObstetrics & Gynecology

Effect of amaranth flatbread on maternal anthropometry during pregnancy: Evidence from a cluster-randomized controlled trial in Southern Ethiopia.

This parallel-group, cluster-randomized controlled trial assessed daily amaranth-chickpea flatbread in pregnant women with mild-to-moderate anemia in Southern Ethiopia.

PLoS OneOct 8, 2026Read summary
Clinical ResearchPhysical Medicine & Rehabilitation

Comparison of two repetitive peripheral magnetic stimulation protocols for upper trapezius myofascial pain syndrome: A randomized trial.

This single-centre, assessor-blinded randomized trial compared 10- and 15-minute repetitive peripheral magnetic stimulation (rPMS) protocols, each given weekly for 4 weeks alongside stretching, in adults aged 18–55 with…

PLoS OneOct 8, 2026Read summary
Clinical ResearchUrologyOpen access

Retroperitoneal lymph node dissection for isolated node recurrence of renal cell carcinoma after nephrectomy: a systematic review.

This systematic review assessed perioperative and oncologic outcomes after retroperitoneal lymph node dissection (RPLND) for isolated nodal recurrence of renal cell carcinoma following nephrectomy.

World J UrolOct 8, 2026Read summary
Clinical ResearchOncology (Medical)

Immunohistochemistry for c-MET, HLA class II, and CD68 does not show prognostic value in early-stage classic Hodgkin lymphoma patients in the EORTC-GELA H9 intergroup randomised trial.

This case-cohort biomarker validation study examined whether immunohistochemical expression of c-MET, HLA class II, or CD68 predicted progression-free survival in patients with early-stage classic Hodgkin lymphoma…

PLoS OneOct 8, 2026Read summary
Clinical ResearchPsychiatryOpen access

The relationship between fear of negative evaluation and social anxiety: a systematic review and meta-analysis.

This systematic review and meta-analysis examined the association between fear of negative evaluation (FNE) and social anxiety (SA) across 143 studies and 146 independent samples, including 80,285 participants.

BMC PsycholOct 8, 2026Read summary

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