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2000 articles

October 202624

Case ReportNephrologyOpen access

Ravulizumab monotherapy for anti-CFH antibody-associated aHUS in an elderly patient: a case report highlighting individualized clinical decision-making.

An 85-year-old man presented with acute kidney injury, thrombocytopenia, microangiopathic hemolytic anemia, and severe hypertension.

CEN Case RepOct 27, 2026Read case
Case ReportGeneral SurgeryOpen access

Novel Fluorescence-Guided Gastric Calibration Tube in Robotic Paraesophageal Hernia Repair.

A 75-year-old woman with symptomatic paraesophageal hiatal hernia and partial gastric volvulus underwent robotic hernia repair with Toupet fundoplication.

CRSLSOct 27, 2026Read case
Case ReportAllergy & Immunology

Disruption of the N-terminal domain in a STAT3 hyper-IgE syndrome variant causes disease by sequestering STAT3 in the cytoplasm.

A patient with a STAT3 R31Q variant presented with disseminated invasive aspergillosis involving the brain and lung, bronchiectasis, and elevated serum IgE, without nonimmune manifestations of hyper-IgE syndrome.

Sci SignalOct 27, 2026Read case
Clinical ResearchOrthopedic SurgeryOpen access

Efficacy and safety of topical versus intravenous tranexamic acid in primary total knee arthroplasty: a systematic review and meta-analysis of randomized controlled trials.

This systematic review and meta-analysis pooled randomized controlled trials comparing topical with intravenous tranexamic acid (TXA) in patients undergoing primary total knee arthroplasty. Eleven trials were included.

Eur J Orthop Surg TraumatolOct 27, 2026Read summary
Clinical ResearchInfectious Diseases

Measles transmission-related epidemiological parameter estimates: a systematic review and meta-analysis.

This systematic review and meta-analysis synthesized English- and French-language primary studies reporting measles transmission-related epidemiological parameters, identified through 14 May 2024.

Epidemiol InfectOct 27, 2026Read summary
Clinical ResearchPediatrics

Efficacy and safety of Lianhua Qingwen versus oseltamivir in children with influenza: a multicenter, randomized, double-blind, positive parallel-controlled study.

This multicenter, randomized, double-blind, positive-controlled trial compared Lianhua Qingwen (LHQW) with oseltamivir in children aged 3–14 years with influenza.

Pharm BiolOct 27, 2026Read summary
Clinical ResearchNeurology

Is resistance training effective to increase BDNF in multiple sclerosis? An updated systematic review and meta-analysis of isolated interventions.

This systematic review and meta-analysis examined whether isolated resistance training (RT) affects peripheral brain-derived neurotrophic factor (BDNF) in people with multiple sclerosis (MS).

PLoS OneOct 27, 2026Read summary
Clinical ResearchObstetrics & GynecologyOpen access

Intrauterine Mepivacaine Instillation vs Placebo for Pain During IUD Placement: A Randomized Clinical Trial.

This multicentre, double-blind, randomised, placebo-controlled trial tested intrauterine mepivacaine before IUD placement in nulliparous individuals aged 18 to 31 years at 11 Swedish clinics.

JAMAOct 27, 2026Read summary
Case ReportObstetrics & Gynecology

Vaginal Angiomyofibroblastoma in a Patient With Warkany Syndrome (Mosaic Trisomy 8): A Case Report.

A 27-year-old nulliparous woman with constitutionally confirmed mosaic trisomy 8 presented with a protruding vaginal mass. MRI showed a well-defined, homogeneously enhancing mid-vaginal lesion and incidentally…

J Obstet Gynaecol ResOct 27, 2026Read case
Clinical ResearchNeurosurgery

Intra-wound Vancomycin Powder for Surgical Site Infection Prophylaxis in Spinal Surgery: A Systematic Review and Meta-analysis.

This systematic review and meta-analysis examined intra-wound vancomycin powder at closure versus no powder in patients undergoing spinal surgery.

J Vis ExpOct 27, 2026Read summary
Clinical ResearchDermatology

Efficacy and safety of icotrokinra for plaque psoriasis: a systematic review and meta-analysis.

This systematic review and meta-analysis assessed icotrokinra, an oral IL-23 receptor antagonist, in adolescents and adults with moderate-to-severe plaque psoriasis.

Clin Exp DermatolOct 27, 2026Read summary
Case ReportPediatricsOpen access

Reconstructive management of an extensive myelomeningocele defect using allogeneic fascia lata as temporary biological coverage: a case-based mini-review.

A term male newborn had a 16 × 10 cm thoracolumbosacral myelomeningocele with too little surrounding skin for tension-free primary closure.

Childs Nerv SystOct 27, 2026Read case
Clinical ResearchInfectious Diseases

Next-Generation Bed Nets to Control Malaria in Côte d'Ivoire.

This cluster-randomized clinical trial compared pyrethroid-only long-lasting insecticidal nets with piperonyl butoxide-pyrethroid (PBO-py) and chlorfenapyr-pyrethroid (CFP-py) nets in villages in Côte d'Ivoire.

NEJM EvidOct 27, 2026Read summary
Clinical ResearchPulmonology

Comparison of the Safety and Efficacy of Remimazolam for Sedation in Adults Undergoing Fiberoptic Bronchoscopy: A Meta-Analysis of Randomized Controlled Trials.

This systematic review and meta-analysis of randomized controlled trials compared remimazolam with other sedatives in adults undergoing fiberoptic bronchoscopy.

J Bronchology Interv PulmonolOct 27, 2026Read summary
Clinical ResearchVascular SurgeryOpen access

Revascularization of Asymptomatic Carotid Artery Stenosis: Cognitive Results of the CREST-2 Randomized Trials.

This prespecified cognitive-outcomes analysis of the multicentre, randomised CREST-2 trials assessed patients aged 35 years or older with at least 70% asymptomatic carotid stenosis.

JAMAOct 27, 2026Read summary
Clinical ResearchPsychiatry

Purrble Use Among LGBTQ+ Young People With Self-Harm Experiences: Findings From a Qualitative Process Evaluation of a Randomized Controlled Trial.

This qualitative process evaluation explored how LGBTQ+ young people with self-harm experiences used and perceived Purrble, a socially assistive robot evaluated in a related randomized controlled trial.

JMIR Form ResOct 27, 2026Read summary
Clinical ResearchOncology (Medical)

Zamtocabtagene autoleucel, a tandem CD20-CD19-directed CAR T-cell therapy, for second line treatment of large B-cell lymphoma in patients ineligible for transplantation (DALY 2-EU): primary analysis of an open-label, multicentre, randomised phase 2 study.

DALY 2-EU was an open-label, multicentre, randomised phase 2 trial comparing tandem CD20-CD19-directed zamtocabtagene autoleucel (zamto-cel) with R-GemOx in adults with second-line relapsed or refractory large B-cell…

Lancet OncolOct 27, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Body image distress in women and men with advanced pancreatic cancer approaching death - post-hoc analyses from the MISTRAL-trial.

This post-hoc analysis of data from the MISTRAL trial examined changes in body image distress and weight worries among 125 women and men with pancreatic cancer during the six months before death.

Support Care CancerOct 27, 2026Read summary
Case ReportPhysical Medicine & Rehabilitation

Ultrasound-Guided High-Voltage Long-Duration Pulsed Radiofrequency of the Suprascapular Nerve for Persistent Hemiplegic Shoulder Pain.

The report describes two patients with persistent hemiplegic shoulder pain after stroke, in whom conventional conservative care or suprascapular nerve blocks may provide inadequate relief.

J Vis ExpOct 27, 2026Read case
Case ReportPulmonology

Two Older Adult Patients With Anorexia and Cachexia Following Refractory Mycobacterium avium-intracellulare Complex Pulmonary Disease Given Acupuncture Treatment to Improve Appetite and Food Intake.

Two older adults with refractory cavitary Mycobacterium avium-intracellulare complex pulmonary disease developed severe anorexia, dyspnea associated with eating, and cachexia.

Am J Case RepOct 27, 2026Read case
Case ReportDermatology

Cutaneous features of SDR9C7 variants in eight individuals with autosomal recessive nonsyndromic epidermal differentiation disorders.

Eight individuals with SDR9C7 variants and nonsyndromic epidermal differentiation disorders had scaling and erythema, commonly with fine scale, hyperlinear palms, and greater involvement of the extremities, particularly…

Clin Exp DermatolOct 27, 2026Read case
Clinical ResearchCardiology

Four weeks of isometric handgrip training results in lower awake ambulatory blood pressure compared with control: a randomized clinical trial.

This randomized controlled trial compared handgrip and knee-extension isometric training with control in 67 adults with controlled hypertension receiving antihypertensive medication.

Clin Physiol Funct ImagingOct 27, 2026Read summary
Clinical ResearchAnesthesiology

Erector spinae plane block added to intercostal nerve block versus intercostal nerve block alone for postoperative analgesia in video-assisted thoracoscopic surgery: A randomized controlled trial.

This prospective, randomized controlled trial compared surgical intercostal nerve block (INB) alone with INB plus single-injection erector spinae plane block (ESPB) in 60 adults undergoing elective three-port…

PLoS OneOct 27, 2026Read summary
Clinical ResearchHematologyOpen access

The role of tyrosine kinase inhibitors as a post-hematopoietic stem cell transplant continuation therapy for pediatric acute leukemia: a systematic review.

This systematic review assessed tyrosine kinase inhibitors (TKIs) as continuation therapy after hematopoietic stem cell transplantation (HSCT) in children with acute leukemia.

Cancer Chemother PharmacolOct 27, 2026Read summary

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