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2000 articles
October 202624
Disruption of the N-terminal domain in a STAT3 hyper-IgE syndrome variant causes disease by sequestering STAT3 in the cytoplasm.
A patient with a STAT3 R31Q variant presented with disseminated invasive aspergillosis involving the brain and lung, bronchiectasis, and elevated serum IgE, without nonimmune manifestations of hyper-IgE syndrome.
Evaluating treatment efficacy for Iliotibial Band Syndrome: A comparison of combined foam rolling and stretching with strengthening exercises versus strengthening alone in athletes.
This randomized controlled trial compared strengthening alone with strengthening plus foam rolling and stretching in 20 athletes with confirmed iliotibial band syndrome.
Two Older Adult Patients With Anorexia and Cachexia Following Refractory Mycobacterium avium-intracellulare Complex Pulmonary Disease Given Acupuncture Treatment to Improve Appetite and Food Intake.
Two older adults with refractory cavitary Mycobacterium avium-intracellulare complex pulmonary disease developed severe anorexia, dyspnea associated with eating, and cachexia.
The role of tyrosine kinase inhibitors as a post-hematopoietic stem cell transplant continuation therapy for pediatric acute leukemia: a systematic review.
This systematic review assessed tyrosine kinase inhibitors (TKIs) as continuation therapy after hematopoietic stem cell transplantation (HSCT) in children with acute leukemia.
Effectiveness of Wrist-Worn Wearable-Guided Cardiac Rehabilitation Delivered Through Fully Remote or Hybrid Programs in Patients With Cardiovascular Disease: Systematic Review and Meta-Analysis of Randomized Controlled Trials.
This systematic review and meta-analysis assessed randomized trials of wrist-worn wearable-guided cardiac rehabilitation delivered remotely or in hybrid formats during phase II or III rehabilitation for adults with…
Efficacy and Safety of Apixaban Thromboprophylaxis According to Baseline Chemotherapy Class in High-Risk Ambulatory Cancer Patients: A Post Hoc Analysis of the AVERT Trial.
This post hoc analysis of the randomized, double-blind AVERT trial examined apixaban thromboprophylaxis by baseline chemotherapy class in 563 ambulatory patients with cancer starting chemotherapy.
Comparison of the Safety and Efficacy of Remimazolam for Sedation in Adults Undergoing Fiberoptic Bronchoscopy: A Meta-Analysis of Randomized Controlled Trials.
This systematic review and meta-analysis of randomized controlled trials compared remimazolam with other sedatives in adults undergoing fiberoptic bronchoscopy.
Measuring the impact of migraine: a systematic review of the measurement properties of MIDAS, HIT-6, and MSQoL.
This systematic review compared the measurement properties of MIDAS, HIT-6, and MSQoL for assessing migraine impact. Following COSMIN methods, it included 22 studies with 20,455 participants.
Rare and Novel Hepatitis C Virus Genotype Subtypes and Response to Sofosbuvir/Velpatasvir in A5360 (MINMON) Clinical Trial.
This analysis of samples from the multicountry ACTG A5360 (MINMON) clinical trial characterized rare and novel hepatitis C virus (HCV) subtypes and assessed baseline resistance-associated substitutions and response to…
Purrble Use Among LGBTQ+ Young People With Self-Harm Experiences: Findings From a Qualitative Process Evaluation of a Randomized Controlled Trial.
This qualitative process evaluation explored how LGBTQ+ young people with self-harm experiences used and perceived Purrble, a socially assistive robot evaluated in a related randomized controlled trial.
Endobronchial Valves for Persistent Air Leak and Bronchopleural Fistula in Children: A Systematic Review of Indications, Procedural Approaches, and Outcomes.
This systematic review examined bronchoscopic endobronchial or intrabronchial valve placement for persistent air leak, bronchopleural fistula, or pneumothorax with ongoing air leak in children and late adolescents.
Comparative effectiveness of three splints for rehabilitation after finger flexor tendon repair (FIRST): randomised controlled trial.
The FIRST pragmatic, multicentre randomised trial compared forearm-based long, Manchester short, and relative motion flexion mini splints for rehabilitation after primary zone 1 or 2 finger flexor tendon repair.
Robot-assisted versus open partial nephrectomy in patients with a solitary kidney: a systematic review and meta-analysis of perioperative and functional outcomes.
This systematic review and meta-analysis compared robot-assisted partial nephrectomy (RAPN) with open partial nephrectomy (OPN) for tumors in a solitary kidney.
The follicular microbiome in hair-follicle-associated inflammatory diseases: a systematic review.
This systematic review qualitatively synthesized culture-independent studies of the bacterial hair-follicle microbiome in inflammatory hair-follicle-associated diseases.
Isolated Disturbance of Consciousness as Initial Presentation of Staphylococcus aureus Endocarditis: A Case Report With Brief Literature Review.
A man in his 50s presented with isolated disturbance of consciousness and no reported fever, although his admission temperature was 38°C.
Haemodynamic and Respiratory Effects of Dexmedetomidine as an Adjuvant to Oxycodone Patient-Controlled Analgesia After Lumbar Spinal Fusion: A Post Hoc Analysis of the DoseRespDex Randomised Controlled Trial.
This post hoc analysis of a randomised, double-blind, placebo-controlled trial examined haemodynamic and respiratory effects of dexmedetomidine added to oxycodone patient-controlled analgesia in 98 adults undergoing…
Air versus supplemental oxygen for resuscitation of term or late preterm infants at birth.
This Cochrane systematic review and meta-analysis assessed randomised and quasi-randomised trials comparing air with supplemental oxygen for resuscitation at birth in term and late preterm infants needing respiratory…
Zamtocabtagene autoleucel, a tandem CD20-CD19-directed CAR T-cell therapy, for second line treatment of large B-cell lymphoma in patients ineligible for transplantation (DALY 2-EU): primary analysis of an open-label, multicentre, randomised phase 2 study.
DALY 2-EU was an open-label, multicentre, randomised phase 2 trial comparing tandem CD20-CD19-directed zamtocabtagene autoleucel (zamto-cel) with R-GemOx in adults with second-line relapsed or refractory large B-cell…
Three-week ileostomy closure after colorectal surgery: a multicenter randomized trial of technical and postoperative outcomes.
This prospective multicenter randomized trial compared ileostomy closure at 3 weeks with conventional delayed closure in 224 patients after restorative colorectal resection.
Vaginal Angiomyofibroblastoma in a Patient With Warkany Syndrome (Mosaic Trisomy 8): A Case Report.
A 27-year-old nulliparous woman with constitutionally confirmed mosaic trisomy 8 presented with a protruding vaginal mass. MRI showed a well-defined, homogeneously enhancing mid-vaginal lesion and incidentally…
Novel Fluorescence-Guided Gastric Calibration Tube in Robotic Paraesophageal Hernia Repair.
A 75-year-old woman with symptomatic paraesophageal hiatal hernia and partial gastric volvulus underwent robotic hernia repair with Toupet fundoplication.
Is resistance training effective to increase BDNF in multiple sclerosis? An updated systematic review and meta-analysis of isolated interventions.
This systematic review and meta-analysis examined whether isolated resistance training (RT) affects peripheral brain-derived neurotrophic factor (BDNF) in people with multiple sclerosis (MS).
A 58-Year-Old Woman with Abdominal Pain, Fever, and Cough.
A 58-year-old woman presented with fever, abdominal pain, and a nonproductive cough. The report describes a diagnostic evaluation using focused history, physical examination, and testing, with the differential diagnosis…
Long-term remission of severe psoriasis following CD19-directed chimeric antigen receptor T-cell therapy for follicular lymphoma.
A 60-year-old woman with a 49-year history of severe plaque psoriasis received autologous CD19-directed CAR-T therapy for follicular lymphoma.
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