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2000 articles

October 202624

Clinical ResearchHematology

Ponatinib-Blinatumomab or Imatinib-Chemotherapy for Adult Ph-Positive ALL.

This multicenter, phase 3 randomized trial compared frontline ponatinib plus blinatumomab with imatinib plus chemotherapy in adults with Philadelphia-positive acute lymphoblastic leukemia.

N Engl J MedOct 15, 2026Read summary
Clinical ResearchInfectious Diseases

Long-Acting HIV Therapy in African Adults with Adherence Challenges.

This phase 3b, open-label, randomized trial compared long-acting injectable cabotegravir plus rilpivirine with daily oral dolutegravir-based therapy in adults in Kenya, South Africa, and Uganda who had suppressed HIV-1…

N Engl J MedOct 15, 2026Read summary
Clinical ResearchInfectious Diseases

Dynamics of QuantiFERON-TB Gold Plus Results in a Large TB Preventive Treatment Trial Across 3 High-Burden HIV/TB Countries.

This longitudinal analysis of a randomized trial assessed serial QuantiFERON-TB Gold Plus (QFT-Plus) results in people with HIV enrolled in Ethiopia, Mozambique, and South Africa and assigned to three TB preventive…

J Infect DisOct 15, 2026Read summary
Clinical ResearchPlastic Surgery

Efficacy of Stromal Vascular Fraction for Scar Prevention: A Multicenter, Double-Blinded, Randomized Controlled Trial.

This multicenter, double-blinded, placebo-controlled randomized trial evaluated intraoperative stromal vascular fraction (SVF) injections for scar prevention in 45 patients undergoing free tissue transfer at three…

Aesthet Surg JOct 15, 2026Read summary
Clinical ResearchMedical Genetics

Safety and efficacy of delpacibart zotadirsen in Duchenne muscular dystrophy mutations amenable to exon 44 skipping in the USA (EXPLORE44): a randomised, placebo-controlled, double-blind, phase 1/2 trial.

EXPLORE44 was a two-part, randomised, double-blind, placebo-controlled phase 1/2 trial at ten US sites, studying delpacibart zotadirsen (del-zota) in healthy adult men and in ambulatory and non-ambulatory males aged…

Lancet NeurolOct 15, 2026Read summary
Clinical ResearchOphthalmology

Comparative Efficacy and Safety of Systemic Immunomodulatory Therapies for Non-Infectious Uveitis: A Systematic Review With Pairwise and Network Meta-Analyses.

This systematic review and network meta-analysis compared systemic immunomodulatory therapies for non-infectious uveitis (NIU), including evidence from seven studies with 992 participants: six randomised trials and one…

PharmacotherapyOct 15, 2026Read summary
Clinical ResearchOncology (Medical)

A Phase II Multicenter Trial of Rucaparib and Nivolumab as Maintenance Therapy in Patients with Advanced Biliary Tract Cancer: BilT-02.

BilT-02 was a multicenter phase II trial of rucaparib plus nivolumab as maintenance therapy for patients with advanced biliary tract cancer whose disease had not progressed after 4 to 6 months of first-line…

Clin Cancer ResOct 15, 2026Read summary
Clinical ResearchHematology

A phase 2 trial of daratumumab monotherapy for patients with newly diagnosed cardiac stage IIIb AL amyloidosis.

This prospective, multicentre phase 2 trial evaluated daratumumab monotherapy in previously untreated patients with measurable AL amyloidosis and advanced cardiac stage IIIB disease; patients with inadequate response…

BloodOct 15, 2026Read summary
Case ReportOncology (Medical)

Primary Intermammary Breast Carcinoma Presenting With Direct Sternal Invasion: A Diagnostic Pitfall of Standard Screening Mammography.

An 85-year-old woman noticed a hard, non-tender sternal nodule despite an unremarkable screening mammogram 8 months earlier.

Am J Case RepOct 15, 2026Read case
Clinical ResearchPediatrics

A Systematic Review of Screen Time and Obesity in Children, Adolescents, and Young Adults: Sex-Specific Pathways and Implications for Public Health Interventions.

This systematic review synthesized evidence on screen time and obesity-related outcomes in children, adolescents, and young adults, examining possible sex-specific patterns.

Prev Chronic DisOct 15, 2026Read summary
Clinical ResearchNeurology

Key Predictors of Cerebral Vasospasm Following Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis examined observational evidence on factors associated with cerebral vasospasm after subarachnoid hemorrhage (SAH).

West J Nurs ResOct 15, 2026Read summary
Clinical ResearchPediatricsOpen access

Comparison of fecal continence and bowel function scoring systems following anorectal malformation repair: a systematic review.

This systematic review assessed whether fecal continence and bowel function scoring systems give comparable results when applied to the same cohorts after anorectal malformation repair.

Pediatr Surg IntOct 15, 2026Read summary
Clinical ResearchOrthopedic SurgeryOpen access

Robotic-assisted conversion of unicompartmental to total knee arthroplasty: a systematic review.

This PRISMA-guided systematic review assessed robotic-assisted conversion of unicompartmental knee arthroplasty (UKA) to total knee arthroplasty (TKA).

J Robot SurgOct 15, 2026Read summary
Case ReportGeneral Surgery

Micro-layering technique for esthetic rehabilitation. A case report.

A male patient sought esthetic rehabilitation for a diastema between the central incisors, mismatched tooth shapes, and overall dental disharmony.

Int J Esthet DentOct 15, 2026Read case
Clinical ResearchOncology (Medical)Open access

A Meta-Analysis on Outcomes of Zanidatamab Plus Chemotherapy in Patients with Advanced HER2-positive Gastroesophageal Adenocarcinoma.

This meta-analysis pooled outcomes from three clinical trials involving 685 patients with advanced HER2-positive gastroesophageal adenocarcinoma treated first-line with zanidatamab plus chemotherapy, with or without…

J Gastrointest CancerOct 15, 2026Read summary
Clinical ResearchUrologyOpen access

Association of immune checkpoint-related polymorphisms in PD-1, PD-L1, and CTLA-4 genes with susceptibility to genitourinary cancer: a meta-analysis.

This meta-analysis pooled evidence from 16 case-control studies examining six single-nucleotide polymorphisms in PD-1, PD-L1, and CTLA-4 genes and susceptibility to genitourinary cancers, including urothelial, renal…

Immunol ResOct 15, 2026Read summary
Case ReportVascular Surgery

PERCUTANEOUS MECHANICAL THROMBECTOMY: A NEW TOOL IN THE TREATMENT OF ACUTE MESENTERIC ISCHEMIA.

An 82-year-old woman with atrioventricular block, hypertension, and dementia presented with acute abdominal pain that had begun three days earlier.

Port J Card Thorac Vasc SurgOct 15, 2026Read case
Clinical ResearchPhysical Medicine & Rehabilitation

AI-Enabled Telerehabilitation for Chronic Nonspecific Neck Pain: Multicenter Randomized Controlled Trial.

This multicenter, prospective, parallel-group randomized noninferiority trial compared AI-enabled home telerehabilitation with exercise-matched outpatient rehabilitation in people with chronic nonspecific neck pain…

JMIR Form ResOct 15, 2026Read summary
Clinical ResearchAnesthesiology

Quality of recovery after arthroscopic meniscectomy with remimazolam or propofol anesthesia: A randomized controlled trial.

This randomized controlled trial compared propofol-based with remimazolam-based total intravenous anesthesia in adults undergoing elective arthroscopic meniscectomy.

PLoS OneOct 15, 2026Read summary
Clinical ResearchNeurology

The ability of the commercial inertial measurement unit-based gait system in determining Parkinson's disease: A systematic review with meta-analysis of cross-sectional studies.

This systematic review and meta-analysis of cross-sectional studies assessed whether commercial inertial measurement unit (IMU)-based gait systems distinguish people with Parkinson’s disease (PD) from healthy controls.

PLoS OneOct 15, 2026Read summary
Clinical ResearchVascular Surgery

The Moderating Effects of Race and Ethnicity on a Motivational Interviewing Intervention for Improving Physical Health Among Patients With Peripheral Artery Disease: Secondary Analysis of a Pilot Randomized Trial.

This secondary analysis of a pilot randomized trial examined whether social determinants of health modified motivational interviewing (MI) effects on walking distance and weight among community-dwelling adults with…

JMIR Form ResOct 15, 2026Read summary
Clinical ResearchPediatrics

Bacterial infections and antibiotic susceptibility in children with sickle-cell anemia on malaria chemoprevention using Dihydroartemisinin-piperaquine (DP) or Sulfadoxine-pyrimethamine (SP) in Uganda.

This analysis nested within a randomized, double-blind trial assessed bacterial infections and antimicrobial resistance among Ugandan children aged 6 months to 15 years with sickle-cell anemia receiving weekly…

PLoS OneOct 15, 2026Read summary
Clinical ResearchPreventive Medicine / Public Health

Acceptability and Feasibility of an Islamic Faith-Based Smoking Cessation Intervention Delivered via WhatsApp for Muslim Smokers in Saudi Arabia: Pilot Randomized Controlled Trial.

This two-arm pilot randomized controlled trial assessed the feasibility, acceptability, and preliminary outcomes of a 21-day Islamic faith-based smoking cessation intervention delivered by WhatsApp to adult Muslim…

JMIR Form ResOct 15, 2026Read summary
Clinical ResearchGeneral SurgeryOpen access

Uniportal versus Multiportal Video-Assisted Thoracoscopic Surgery for Minimally Invasive Esophagectomy in Esophageal Cancer: A GRADE-Assessed Systematic Review and Meta-Analysis.

This GRADE-assessed systematic review and meta-analysis compared uniportal (uVATS) with multiportal video-assisted thoracoscopic surgery (mVATS) for minimally invasive esophagectomy in adults with esophageal cancer.

J Gastrointest CancerOct 15, 2026Read summary

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