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1759 articles
September 202624
Does a Simple Touch Make a Difference? The Effect of Acupressure on Pain Scores in Infants Undergoing Cardiac Catheterization: A Randomized, Placebo-Controlled Trial.
This randomized, placebo-controlled trial evaluated acupressure in 60 infants aged 1–12 months with congenital heart disease undergoing cardiac catheterization.
Sex differences in the efficacy, acceptability, and tolerability of antipsychotics in people with acute schizophrenia: individual participant data pairwise, dose-response, and network meta-analyses.
This individual participant data pairwise, dose-response, and network meta-analysis examined sex differences in antipsychotic efficacy, acceptability, and tolerability in adults with acute schizophrenia.
More than meets the eye: A meta-analysis of visual outcomes following clipping, coiling, and flow diversion for visually symptomatic paraclinoid aneurysms.
This PRISMA-compliant systematic review and random-effects meta-analysis compared visual outcomes after clipping, coiling, and flow diversion for paraclinoid aneurysms, drawing on 21 studies.
8 weeks versus 12 weeks of sofosbuvir-velpatasvir for treatment-naive, non-cirrhotic, chronic hepatitis C (RESOLVE): a multicentre, open-label, non-inferiority, randomised controlled trial in India.
The RESOLVE multicentre, open-label, randomised non-inferiority trial compared 8 versus 12 weeks of daily sofosbuvir-velpatasvir in treatment-naive adults with chronic hepatitis C without cirrhosis at five publicly…
Cardiovascular safety of orforglipron versus insulin glargine in adults with type 2 diabetes at increased cardiovascular risk (ACHIEVE-4): a phase 3, event-driven, randomised, open-label, non-inferiority, active comparator trial.
ACHIEVE-4 was a phase 3, event-driven, multicentre, randomised, open-label, active-comparator non-inferiority trial comparing once-daily oral orforglipron with titrated insulin glargine in adults with type 2 diabetes…
Prognostic Models for Predicting the Severity and Mortality in People With Acute Pancreatitis - A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed how accurately four clinical scoring systems predict severe acute pancreatitis (SAP) and mortality in adults.
BK Virus-Associated Hemorrhagic Cystitis in Nontransplanted Children With Hematological Malignancies: A Single-Center Case Series.
A single-center retrospective series identified six nontransplanted children with leukemia or lymphoma who developed BK virus-associated hemorrhagic cystitis during a 17-year period.
A Novel Pathogenic Variant in RTEL1 Causes Dyskeratosis Congenita/Hoyeraal-Hreidarsson Syndrome: A Report of Two Cases.
Two patients presented with severe immunodeficiency and very early-onset inflammatory bowel disease. Genetic testing identified the same novel homozygous RTEL1 variant, c.1670T>C (p.L557P).
Neurosyphilis Concurrently Presenting With Limbic Encephalitis and Normal Pressure Hydrocephalus: A Case Report.
A 47-year-old man presented with cognitive decline, gait disturbance, and urinary incontinence. Imaging revealed ventricular enlargement and high signal intensity in the medial temporal lobes.
Epigenetic Programming of Stress-Response Systems: A Systematic Review of How Early Life Stress Shapes Developmental Trajectories of Mental Health.
This systematic review examines how early life stress (ELS) influences mental health development through epigenetic mechanisms, particularly DNA methylation, in 14 empirical human studies.
Hypofractionated versus conventional fractionated postmastectomy radiotherapy for patients with high-risk breast cancer (CHN HYPOPMRT): 10-year outcomes from a randomised, non-inferiority, open-label, phase 3 trial.
This phase 3 randomized trial compared hypofractionated (43.5 Gy in 15 fractions) and conventional (50 Gy in 25 fractions) postmastectomy radiotherapy in 810 women with high-risk breast cancer.
A Case Report to Explore A Wrong-Site Surgery Error.
A case of wrong-site surgery involved an incorrect nerve block performed during a nonemergent orthopedic procedure. Despite some verification steps being completed, the incident was attributed to lapses in established…
Prophylactic Immediate Lymphatic Reconstruction for the Prevention of Secondary Lymphedema: A Systematic Review and Meta-Analysis of Comparative Studies.
This systematic review and meta-analysis evaluated the effectiveness of prophylactic lymphovenous shunting (LVS) in preventing secondary lymphedema in 2261 patients undergoing axillary and inguinal lymph node…
Long-term clinical outcomes of stem cell-based interventions in Crohn's-related perianal fistula: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the long-term outcomes of stem cell-based interventions for Crohn's disease-related perianal fistulas in 750 patients.
Continuous Versus Routine EEG in Critically Ill Patients Without Primary Neurologic Condition: Analysis of a Randomized Controlled Trial.
This post hoc analysis of the multicenter randomized CERTA trial evaluated the effectiveness of continuous EEG (cEEG) versus routine EEG (rEEG) in critically ill patients without primary neurologic conditions.
Designing Youth Early Intervention in Psychosis Services: A Secondary Framework Synthesis of Organisational Recommendations.
This systematic review synthesized organizational recommendations from 26 international guidelines on early intervention in psychosis (EIP) for youth.
The Effect of Carbetocin on Cardiac Repolarization: A Randomized, Placebo- and Positive-Controlled QT/QTc Study in Healthy Adults.
This randomized controlled trial assessed the impact of a supratherapeutic dose of carbetocin on cardiac repolarization in 42 healthy adults.
Unveiling the Prognostic Power of Circulating Tumor DNA in Multiple Myeloma: A Systematic Review and Updated Meta-Analysis.
This systematic review and meta-analysis evaluated the prognostic significance of circulating tumor DNA (ctDNA) in 948 patients with multiple myeloma (MM).
A Heterozygous Variant in the GABBR2 Gene in a Girl With Clinical Classic Rett Syndrome.
A girl diagnosed with classic Rett syndrome exhibited developmental stagnation, loss of purposeful hand use, stereotypic movements, autonomic dysfunction, and behavioral issues.
The Effect of Emotional Freedom Techniques on Death Anxiety and Cancer-Related Anxiety in Patients Undergoing Oncological Surgery: A Randomized Controlled Trial.
This randomized controlled trial examined the impact of emotional freedom techniques (EFT) on death anxiety and cancer-related anxiety in 120 patients undergoing oncological surgery.
The Effect of Oropharyngeal Colostrum Administration on Early Feeding Skills and Transition to Oral Feeding in Preterm Infants: A Randomized Controlled Trial.
This randomized controlled trial investigated the impact of oropharyngeal colostrum administration on oral feeding readiness in 60 preterm infants (26 0 to 33 6/7 weeks gestation).
Purely transvenous treatment of cervical paraspinal arteriovenous fistulas.
This report details two patients with paraspinal arteriovenous fistulas (PSAVF) treated using a purely transvenous approach.
FOXG1 syndrome: genetic background revealed by trio WES in case of a critically ill neonate.
A male neonate presented with hypotonia and abnormal respiratory effort at birth. Due to the serious and non-specific clinical signs, trio whole-exome sequencing (WES) was performed, revealing a de novo heterozygous…
A rare case of hereditary spastic paraplegia with homozygous mutation in the ZFYVE26 gene.
A 19-year-old female with consanguineous parents presented with gait disturbances, lower limb spasticity, and dysarthria. Neurological examination revealed motor and mental retardation, bilateral lower limb spasticity…
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