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433 articles
August 20266
Dynamic nature of maternal multiple RBC alloantibodies after vaccination: Case report and immunological mechanisms review.
A 35-year-old pregnant woman presented with multiple red blood cell alloantibodies, including anti-D, anti-C, anti-Fya, and anti-M, detected early in her pregnancy.
Pegtarazimod limits acute graft-versus-host disease mortality and severity in mice and is tolerated in patients.
This phase II clinical trial evaluated the efficacy and tolerability of pegtarazimod in patients with corticosteroid-refractory acute graft-versus-host disease (aGVHD).
Longitudinal Molecular Characterization of a Rare TPM3::PDGFRB-Rearranged Myeloid/Lymphoid Neoplasm With Late CNL-Like Neutrophilic Evolution.
An elderly patient presented with hypereosinophilia and a balanced t(1;5)(q21;q33), with PDGFRB rearrangement detected in 70% of nuclei.
Natural Killer Cell Immunotherapy After Allogeneic Hematopoietic Stem Cell Transplantation in Acute Leukemia Patients: Phase I Clinical Trial.
This Phase I clinical trial evaluated the safety and efficacy of interleukin-15-activated CD56+ cell infusion in patients with acute leukemia post-allogeneic hematopoietic stem cell transplantation.
Exposure-Response Analyses to Inform the Optimal Epcoritamab Monotherapy Dosing Regimen in Relapsed or Refractory Follicular Lymphoma.
This phase I/II clinical trial evaluated the dosing regimen of epcoritamab in patients with relapsed or refractory follicular lymphoma.
Blinatumomab versus chemotherapy in pediatric B-ALL: A meta-analysis of randomized trials in relapsed and high-risk frontline disease.
This meta-analysis evaluated the efficacy of blinatumomab compared to chemotherapy in pediatric patients with relapsed/refractory or high-risk frontline B-cell acute lymphoblastic leukemia (B-ALL).
July 202618
Hematological changes in formaldehyde-exposed workers: A critical review and meta-analysis.
This meta-analysis reviewed 22 studies to evaluate the hematotoxicity of formaldehyde (FA) exposure among workers. It found significant associations with changes in blood parameters, specifically a standardized mean…
Recurrent KCNN4 p.Ser314Pro variant in a child with Gardos channelopathy: a 6-year follow-up.
A child with Gardos channelopathy due to a recurrent KCNN4 p.Ser314Pro variant was followed for 6 years. The patient maintained a stable baseline but experienced hemolytic crises triggered by infections and exacerbated…
Polyclonal B-cell lymphocytosis: a rare, benign condition that mimics a chronic lymphoproliferative disorder.
A patient with a history of smoking presented with abdominal discomfort and weight loss, leading to a diagnosis of persistent polyclonal B-cell lymphocytosis (PPBL) after laboratory tests showed elevated polyclonal IgM…
Rare clinical complications following scorpion envenomation worldwide: A systematic review.
This systematic review examined rare clinical complications from scorpion envenomation, analyzing articles from 2000 to 2025.
Late acquisition of BCR::ABL1 during clonal evolution of SAMD9-associated MDS with phenotypic shift from AML to B-ALL.
This case describes a patient with SAMD9-associated myelodysplastic syndrome (MDS) with monosomy 7, which evolved over 16 years into BCR::ABL1-positive acute myeloid leukemia (AML) and later transformed into B-cell…
Neuralgic Amyotrophy Following B-Cell Maturation Antigen-Directed CAR-T Therapy.
This report describes four patients who developed neuralgic amyotrophy following B-cell maturation antigen-directed CAR-T therapy, representing 1.5% of treated patients.
Hypophosphataemia following iron infusion: a narrative review of an increasingly recognised complication.
This narrative review discusses five cases of hypophosphataemia following intravenous iron infusion, a complication increasingly recognized in clinical practice.
Long-term remission of chronic-type adult T-cell leukemia/lymphoma associated with Graves' disease treated with methimazole.
A 58-year-old woman diagnosed with chronic-type adult T-cell leukemia/lymphoma (ATL) in 2022 experienced disease progression alongside the development of Sjögren's syndrome and Graves' disease in 2023.
A case of bone marrow-liver-spleen type diffuse large B-cell lymphoma: importance of rapid diagnosis and therapeutic intervention.
A 73-year-old woman presented with multiorgan failure and disseminated intravascular coagulation, raising concerns for secondary hemophagocytic lymphohistiocytosis.
Allogeneic hematopoietic stem cell transplantation achieves complete response in refractory primary mediastinal large B-cell lymphoma after the failure of chemotherapy, CAR-T therapy, and PD-1 blockade.
A 19-year-old female with refractory primary mediastinal large B-cell lymphoma (PMBCL) experienced a central nervous system relapse after partial response to chemotherapy.
From Stigma to Suffering: Stigma, Health-Related Quality of Life, and Healthcare Access in Sickle Cell Disease-A Global Systematic Review.
This systematic review examined the impact of stigma on health-related quality of life (HRQoL) and healthcare access in individuals with sickle cell disease (SCD).
Recombinant Human Thrombopoietin Reduces the Need for Platelet Transfusion in Patients With Chronic Liver Disease and Thrombocytopenia.
This multicenter, randomized, double-blind, placebo-controlled phase III trial evaluated recombinant human thrombopoietin (rhTPO) in 120 adults with chronic liver disease-related thrombocytopenia undergoing elective…
Durable platelet response and immature platelet indices following sequential efgartigimod and eltrombopag therapy in a patient with refractory ITP.
A patient with refractory immune thrombocytopenia (ITP) received efgartigimod, which led to a partial platelet response. This response was further enhanced by the addition of eltrombopag, resulting in durable remission…
Therapeutic-drug-monitoring-based ATG Targeted Dosing Strategy in Unmanipulated Haploidentical Haematopoietic Stem Cell Transplantation: a randomized, multicenter, phase 3 clinical trial.
This randomized, multicenter, phase 3 trial evaluated a therapeutic-drug-monitoring (TDM)-based dosing strategy for anti-thymocyte globulin (ATG) in haploidentical hematopoietic stem cell transplantation.
Population Pharmacokinetics of Bosutinib in Children with Philadelphia Chromosome-Positive Chronic Myelogenous Leukemia Based on a Phase I Dose-Finding Trial (ITCC-054/COG AAML1921) and Pediatric Recommended Phase II Dosage Evaluation.
This study investigated the population pharmacokinetics of bosutinib in 26 pediatric patients with Philadelphia chromosome-positive chronic myelogenous leukemia, utilizing data from a Phase I dose-finding trial.
Long-term follow-up, complications and outcomes of Meso-Rex bypass for extrahepatic portal vein obstruction (EHPVO): a systematic review.
This systematic review evaluated long-term outcomes of Meso-Rex Bypass (MRB) in pediatric patients with extrahepatic portal vein obstruction (EHPVO).
How We Approach Bridging Pediatric Sickle Cell Care and the School Experience.
Children with sickle cell disease (SCD) experience school-based barriers that affect well-being and long-term outcomes. This article reframes school as a partner and core site of care.
Romiplostim for chemotherapy induced thrombocytopenia in pediatric cancers.
This investigator-initiated, open-label randomized trial at a tertiary centre in India evaluated prophylactic romiplostim in 93 children aged 1–14 years with AML, non-Hodgkin lymphoma, or solid tumours receiving…
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