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406 articles

April 202621

Clinical ResearchNephrologyOpen access

A prospective, randomized, double-blind, placebo-controlled, multicenter study of thiamin plus folic acid in the treatment of cognitive impairment in patients undergoing maintenance hemodialysis.

This randomized, double-blind, placebo-controlled trial evaluated the effects of thiamin and folic acid on cognitive impairment in 215 maintenance hemodialysis patients.

Ren FailApr 30, 2026Read summary
Clinical ResearchCardiologyOpen access

Effect of intensive versus standard blood pressure control on cardiovascular outcomes: a meta-analysis of randomized controlled trials.

This meta-analysis evaluated the effects of intensive versus standard blood pressure control on cardiovascular outcomes in 156,933 hypertensive patients across 31 randomized controlled trials.

Ann MedApr 30, 2026Read summary
Clinical ResearchGeriatrics

The diagnostic accuracy of blood biomarkers for sarcopenia, sarcopenic obesity, and osteosarcopenia: a meta-analysis.

This meta-analysis evaluated the diagnostic accuracy of blood biomarkers for sarcopenia and related conditions across various populations.

Arch Gerontol GeriatrApr 30, 2026Read summary
Case ReportInternal Medicine (General)

Probable interaction between warfarin and a toothache solution containing Piper longum L. leading to ischemic stroke: a case report.

A patient with a mechanical heart valve on warfarin experienced fluctuations in their international normalized ratio (INR) and subsequently suffered an ischemic stroke.

J EthnopharmacolApr 29, 2026Read case
Clinical ResearchPsychiatryOpen access

Evaluating comparative effect of non-pharmacological interventions adjunctive to opioid agonist therapy for opioid use disorder: A systematic review with network meta-analysis.

This systematic review and network meta-analysis evaluated the efficacy of non-pharmacological interventions as adjuncts to opioid agonist therapy (OAT) in patients with opioid use disorder (OUD).

AddictionApr 28, 2026Read summary
Clinical ResearchCardiologyOpen access

ADA-HF: acetazolamide as a chloride sparing diuretic in patients admitted to hospital with heart failure.

The ADA-HF study evaluated the effects of oral acetazolamide (ACZ) on diuresis and chloride loss in hospitalized heart failure patients.

Clin Res CardiolApr 27, 2026Read summary
Clinical ResearchCardiologyOpen access

HI-PLUS: design of a cluster-randomized trial evaluating structured case management with telemonitoring to improve quality of life in heart failure.

The HI-PLUS trial is a cluster-randomized controlled trial designed to evaluate a structured case management intervention with telemonitoring aimed at improving quality of life in heart failure patients.

Clin Res CardiolApr 27, 2026Read summary
Clinical ResearchCardiology

Exploring the role of successful exercise-induced body weight loss on cardiometabolic health in individuals with metabolic syndrome.

This randomized controlled trial investigated the impact of high-intensity interval training (HIIT) on cardiometabolic health in 228 adults with metabolic syndrome.

Nutr Metab Cardiovasc DisApr 25, 2026Read summary
Clinical ResearchPsychiatryOpen access

Stimulant use and increased severity of opioid use disorder and mental illness in patients with co-occurring disorders.

This cross-sectional study examined the relationship between stimulant use and the severity of opioid use disorder (OUD) and mental illness in primary care patients with co-occurring depression and/or PTSD.

J Subst Use Addict TreatApr 24, 2026Read summary
Clinical ResearchEndocrinology

Cost-effectiveness of tirzepatide versus semaglutide for patients with obesity or overweight in the US: evidence from the SURMOUNT-5 head-to-head phase-3 trial.

This study assessed the cost-effectiveness of tirzepatide versus semaglutide in adults with obesity or overweight in the US, using data from the Phase-3 SURMOUNT-5 trial.

J Med EconApr 21, 2026Read summary
Clinical ResearchPulmonology

From fibrosis to thrombosis: a systematic review and meta-analysis of venous thromboembolism risk in interstitial lung disease.

This systematic review and meta-analysis evaluated the risk of venous thromboembolism (VTE) in patients with interstitial lung disease (ILD) compared to controls.

Expert Rev Respir MedApr 21, 2026Read summary
Clinical ResearchCardiology

Influence of Baseline Smoking Status on Intensive Blood Pressure Control: Results From the STEP Randomized Trial.

This secondary analysis of the STEP randomized trial evaluated the impact of baseline smoking status on cardiovascular outcomes in 8489 elderly hypertensive patients.

Can J CardiolApr 21, 2026Read summary
Clinical ResearchEndocrinology

Patient Preferences, Perceptions, and Influencing Factors in Weight Loss Pharmacotherapy and Bariatric Surgery: A Systematic Literature Review.

This systematic review analyzed patient preferences regarding weight loss pharmacotherapy and bariatric surgery among adults with overweight or obesity.

Value HealthApr 21, 2026Read summary
Clinical ResearchEmergency Medicine

Paracetamol adducts following overdose treated with a shorter acetylcysteine infusion: findings from the NACSTOP 2 trial.

The NACSTOP 2 trial investigated the effects of a 12-hour versus a 20-hour acetylcysteine infusion on paracetamol adducts in low-risk overdose patients.

Clin Toxicol (Phila)Apr 20, 2026Read summary
Clinical ResearchInternal Medicine (General)

Effects of Mindfulness-Based Interventions (MBI) on Blood Pressure Among Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

This systematic review and meta-analysis evaluated the impact of mindfulness-based interventions (MBIs) on blood pressure in adults, analyzing 21 randomized controlled trials with 2002 participants.

J Cardiovasc NursApr 17, 2026Read summary
Clinical ResearchVascular Surgery

Osteopathic manipulative medicine lymphatic drainage techniques for venous insufficiency and peripheral arterial disease: a review.

This systematic review evaluated the effectiveness of osteopathic manipulative medicine (OMM) lymphatic drainage techniques in patients with chronic venous insufficiency (CVI) and peripheral arterial disease (PAD).

J Osteopath MedApr 16, 2026Read summary
Case ReportEndocrinology

Severe Hypoglycemia Associated With High-Dose Methadone in a Patient With ESRD: A Case Report and Review.

A 49-year-old man with end-stage renal disease on hemodialysis experienced severe hypoglycemia while on high-dose methadone. Laboratory tests indicated endogenous hyperinsulinemia as the underlying cause.

Pain Manag NursApr 16, 2026Read case
Clinical ResearchEndocrinology

The Impact of Hemoglobin Concentration on Prognosis in Patients With Diabetic Foot: A Systematic Review and Meta-Analysis of Risk Factors for Adverse Outcomes and Clinical Management.

This systematic review and meta-analysis evaluated the relationship between hemoglobin concentration and adverse outcomes in 10,984 patients with diabetic foot complications.

Am SurgApr 15, 2026Read summary
Clinical ResearchCardiologyOpen access

Effects of vitamin D 3 supplementation on cardiac, muscle, and immune responses after a marathon race: a single-blind, placebo-controlled trial.

This single-blind, placebo-controlled randomised trial examined whether 8 weeks of vitamin D₃ supplementation altered cardiac, muscle, oxidative-stress, and immune responses after a full marathon in 21 amateur runners.

J Int Soc Sports NutrApr 12, 2026Read summary
Clinical ResearchEmergency Medicine

Effect of catheter advancement technique on needle tip motion during peripheral intravenous insertion.

This prospective, randomized-order, within-subject crossover study compared needle-tip motion during three peripheral intravenous catheter advancement techniques.

J Vasc AccessApr 11, 2026Read summary
Case ReportEmergency Medicine

Slow Symptom Resolution of Acute Altitude Illness Upon Rapid Descent.

A hiker developed acute mountain sickness (AMS) at altitude and descended rapidly to sea level, yet symptoms persisted for nearly 24 hours.

High Alt Med BiolApr 8, 2026Read case

March 20263

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