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1316 articles

October 202624

Clinical ResearchPediatricsOpen access

Daily Zinc Supplementation for Infection Prevention in Children With Sickle Cell Anemia: The ZIPS-2 Randomized Clinical Trial.

The ZIPS-2 randomized, double-blind, placebo-controlled trial evaluated daily zinc for infection prevention in children aged 1 to 4.99 years with sickle cell anemia in Uganda.

JAMAOct 13, 2026Read summary
Clinical ResearchGastroenterology

Network Meta-Analysis: Treatments for Acute Alcohol-Associated Hepatitis.

This systematic review and network meta-analysis compared treatments for alcohol-associated hepatitis (AH) using 90-day survival as the primary outcome.

Liver IntOct 13, 2026Read summary
Clinical ResearchGeriatrics

Feasibility of Online and On-Site Physical Activity Delivery Among Older Adults: Mixed Methods Pilot Randomized Controlled Trial.

This unblinded, site-cluster-randomized mixed methods pilot trial assessed the feasibility of a 26-week Otago physical activity program delivered online or in person to community-dwelling adults aged 60 years or older…

JMIR Form ResOct 13, 2026Read summary
Clinical ResearchNeurologyOpen access

Long-Term Quantitative MRI and Quality-of-Life After Endovascular Therapy in Acute Ischemic Stroke - A MR CLEAN-NO IV Substudy.

This long-term substudy of the MR CLEAN-NO IV randomised trial examined quantitative MRI and quality of life three years after acute ischaemic stroke.

Transl Stroke ResOct 13, 2026Read summary
Clinical ResearchOtolaryngology (ENT)

Adenotonsillectomy for children with mild sleep-disordered breathing: who benefits?

This secondary analysis of a 12-month, multicentre randomised trial examined children aged 3.0–12.9 years with mild sleep-disordered breathing, comparing early adenotonsillectomy (eAT) with watchful waiting and…

SleepOct 13, 2026Read summary
Clinical ResearchCardiologyOpen access

Cold and Room-Temperature Platelets in Cardiac Surgery: The CHIPS Randomized Clinical Trial.

The phase 3, multicenter, randomized CHIPS trial compared cold-stored platelets (CSPs; up to 21 days) with room-temperature platelets (RTPs; up to 7 days) in pediatric and adult patients receiving platelet transfusions…

JAMAOct 13, 2026Read summary
Clinical ResearchObstetrics & Gynecology

Elinzanetant in postmenopausal women with sleep disturbance: results from the randomized, phase II NIRVANA study.

The phase II NIRVANA randomised trial assessed elinzanetant versus placebo in 110 postmenopausal women aged 40–65 years with moderate-to-severe vasomotor symptoms and objectively measured sleep disturbance.

SleepOct 13, 2026Read summary
Clinical ResearchPhysical Medicine & Rehabilitation

Six-month supervised telerehabilitation combining pilates-based therapeutic exercise and self-myofascial release in adults with fibromyalgia: a randomized controlled trial.

This two-arm randomized controlled trial evaluated a six-month supervised home-based telerehabilitation programme in 68 adults with fibromyalgia confirmed by 2016 ACR criteria.

J Rehabil MedOct 13, 2026Read summary
Clinical ResearchPediatrics

Prevalence and genotype distribution of norovirus and rotavirus among children under five with diarrheal infection in lower-middle-income countries after Rotavirus vaccine introduction: A systematic review and meta-analysis.

This systematic review and meta-analysis assessed norovirus and rotavirus prevalence and genotype distribution among children under five with diarrheal infection in low- and middle-income countries after rotavirus…

PLoS OneOct 13, 2026Read summary
Clinical ResearchPediatrics

Cost comparison of the ShangRing device versus Mogen clamp for early infant male circumcision in Sub-Saharan Africa.

This cost comparison alongside a randomized controlled trial assessed early infant male circumcision using the ShangRing (SR) versus the Mogen clamp (MoC) among infants aged 0–60 days in Kenya, Tanzania, and Uganda.

PLoS OneOct 13, 2026Read summary
Clinical ResearchNeurology

Post-Stroke Depression and Determinants in Ethiopia; A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis examined the prevalence and determinants of post-stroke depression (PSD) in Ethiopia, combining findings from eight studies.

Int J Methods Psychiatr ResOct 13, 2026Read summary
Clinical ResearchOphthalmology

USB-powered vs. self-heating warm compresses for meibomian gland dysfunction: A prospective randomized crossover clinical trial.

This prospective randomized crossover trial compared USB-powered and self-heating warm compresses in 15 adults aged 18–40 years with meibomian gland dysfunction and tear break-up time ≤10 s.

PLoS OneOct 13, 2026Read summary
Clinical ResearchUrologyOpen access

Robot-assisted ileal ureter replacement for complex ureteral strictures: a systematic review and single-arm meta-analysis of surgical and functional outcomes.

This systematic review and single-arm meta-analysis assessed surgical and functional outcomes after robot-assisted ileal ureter replacement (RIUR) in adults with complex ureteral strictures.

J Robot SurgOct 12, 2026Read summary
Clinical ResearchPsychiatry

Predicting IGD treatment outcomes across interventions using a whole-brain functional connectome biomarker.

This clinical trial study examined whether resting-state whole-brain functional connectivity could predict symptom improvement in 90 individuals with internet gaming disorder (IGD) receiving mindfulness meditation…

Dialogues Clin NeurosciOct 12, 2026Read summary
Clinical ResearchOphthalmologyOpen access

Oral eplerenone in first-episode acute central serous chorioretinopathy: results of a double-masked randomized trial.

This double-masked, randomized, placebo-controlled trial evaluated oral eplerenone in 44 patients with first-episode acute central serous chorioretinopathy (CSCR).

Int OphthalmolOct 12, 2026Read summary
Clinical ResearchUrologyOpen access

Comparative perioperative outcomes of Hugo™ RAS versus laparoscopic and Da Vinci platforms for partial nephrectomy: a systematic review and meta-analysis.

This systematic review and meta-analysis compared Hugo™ RAS with da Vinci-assisted and laparoscopic partial nephrectomy. It included four observational cohort studies comprising 383 patients.

J Robot SurgOct 12, 2026Read summary
Clinical ResearchPediatrics

Home visits following hospital discharge for families with preterm and low-birthweight infants.

This Cochrane systematic review and meta-analysis assessed randomised trials of home visits after discharge for families of preterm or low-birthweight infants.

Cochrane Database Syst RevOct 12, 2026Read summary
Clinical ResearchCardiology

Blood pressure targets in adults with hypertension.

This publication is a protocol for a Cochrane intervention review, not a report of completed results. It sets out to assess lower blood pressure targets (≤ 135/85 mmHg) versus standard targets (≤ 140 to 160/90 to 100…

Cochrane Database Syst RevOct 12, 2026Read summary
Clinical ResearchEmergency MedicineOpen access

The impact of kinesiotaping on functional respiratory outcome in chest injuries-a pilot randomized trial.

This pilot randomized trial compared kinesiotaping (KT) plus breathing exercises with breathing exercises alone in 34 patients with isolated unilateral injuries involving fewer than five ribs.

PeerJOct 12, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Stereotactic body radiotherapy versus conventional external beam radiotherapy for bone metastases: a meta-analysis.

This systematic review and meta-analysis compared stereotactic body radiotherapy (SBRT) with conventional external beam radiotherapy (cEBRT) for painful bone metastases, pooling comparative clinical studies using…

Clin Exp MetastasisOct 12, 2026Read summary
Clinical ResearchUrologyOpen access

Laparoscopic and robotic management of symptomatic calyceal diverticula: a systematic review on behalf of YAU and EAU endourology.

This systematic review assessed laparoscopic and robot-assisted management of symptomatic calyceal diverticula. Nine studies were included in a qualitative synthesis.

World J UrolOct 12, 2026Read summary
Clinical ResearchInfectious DiseasesOpen access

Dynamics and functional heterogeneity of FOXP3+ regulatory T cells in Trypanosoma cruzi infection: a systematic review.

This systematic review synthesised 27 studies of FOXP3+ regulatory T-cell (Treg) phenotype and function in human and experimental Trypanosoma cruzi infection: 9 human studies and 18 murine studies.

Inflamm ResOct 12, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Resilience interventions for stress-related health outcomes in patients with cancer: Findings from a systematic review of randomized controlled trials.

This systematic review synthesized randomized controlled trials of resilience interventions for stress-related health outcomes in patients with cancer.

Support Care CancerOct 12, 2026Read summary
Clinical ResearchPlastic SurgeryOpen access

Anatomical variation in the cervical branch of the facial nerve: a systematic review.

There is a paucity of literature on the anatomical variations of the cervical branch of the facial nerve (CBFN). Poor awareness of its anatomy and variations risks intraoperative damage, misdiagnosis of facial nerve…

Surg Radiol AnatOct 12, 2026Read summary

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