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1022 articles
September 202624
The prevalence of frontotemporal dementia: a systematic review and meta-analysis.
This systematic review and meta-analysis estimated the global prevalence of frontotemporal dementia (FTD) in individuals under 65, analyzing 21 studies with 38,656,516 participants.
Hereditary connective tissue disorders in unselected patients with spontaneous cervical artery dissection: a targeted next generation sequencing approach and systematic review.
This study investigated the prevalence of clinically relevant genetic variants in 183 unselected patients with spontaneous cervical artery dissection (sCeAD) using targeted next-generation sequencing.
Safety, Immunovirologic, and Central Nervous System Effects of PD-1 Inhibition in People With HIV Without Malignancy.
This phase 1 nonrandomized clinical trial evaluated the safety and effects of a single dose of pembrolizumab in 6 individuals with virally suppressed HIV.
First Prospective, Single-Arm, Multicenter Study to Evaluate the Safety and Efficacy of the Overall Thrombectomy System for Stroke: iNedit, iNdeep, and iNtercept in Patients with Acute Ischemic Stroke (SEMTiC-01 Study).
The SEMTiC-01 study is a prospective, multicenter, single-arm trial evaluating the safety and efficacy of a novel neurothrombectomy system in 175 patients with acute ischemic stroke due to large vessel occlusion.
Chiari Decompression in Patients with Spontaneous Intracranial Hypotension: Presenting Symptoms and Treatment Response.
Seven patients with spontaneous intracranial hypotension (SIH) were initially misdiagnosed with Chiari malformation type I and underwent posterior fossa decompression.
Efficacy and safety of extended-release carbidopa-levodopa (IPX203) versus immediate-release carbidopa-levodopa for Parkinson's disease: A systematic review.
This systematic review evaluated the efficacy and safety of extended-release carbidopa-levodopa (IPX203) versus immediate-release carbidopa-levodopa in patients with advanced Parkinson's disease.
Prevalence of Slowly Expanding Lesions in Patients With Multiple Sclerosis: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the prevalence of slowly expanding lesions (SELs) in 4,786 patients with multiple sclerosis (MS).
Pearls & Oy-sters: DPPX Antibody-Associated Encephalitis in a Patient With Diarrhea, Tremor, Ocular Flutter, and Cognitive-Psychiatric Changes.
A 57-year-old man presented with a 2-month history of progressive gastrointestinal symptoms, followed by neurological manifestations including tremor, myoclonus, and cognitive changes.
Clinical Reasoning: A Patient With Progressive Sensory Neuropathy: Using Nerve Ultrasound and Skin Biopsy to Refine Diagnostic Reasoning.
A 74-year-old man presented with a 5-year history of progressive feet numbness followed by gait unsteadiness. Neurologic examination revealed absent tendon reflexes, markedly reduced vibration sense in the lower limbs…
P7C3 Compounds as Targeted Mitochondrial Therapeutics for Brain Disorders.
This systematic review evaluates P7C3 compounds, which activate NAMPT and enhance NAD+ levels, across various neurological disorders.
Impact of Baseline Polyneuropathy Severity on Eplontersen Efficacy in the NEURO-TTRansform Clinical Trial.
This post hoc analysis of the NEURO-TTRansform trial evaluated the effect of baseline severity of hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN) on the efficacy of eplontersen.
Intrathecal Chemotherapy Through Ommaya Reservoir in Leptomeningeal Metastasis From Cervical Cancer: A Rare Case Report and Literature Review.
A 61-year-old woman with stage IVB cervical squamous cell carcinoma presented with acute headache and diplopia during systemic chemotherapy. Brain MRI indicated leptomeningeal metastasis, confirmed by CSF cytology.
Semiology of Opercular Epilepsies.
This systematic review analyzed the semiology of 'pure' opercular seizures in 70 patients across four anatomical groups: frontal, central, parietal, and temporal operculum.
Dual Transcranial Direct Current Stimulation Modulates Hierarchical Functional Network Organization in Post-Stroke Cognitive Impairment: A Randomized Controlled Trial.
This randomized controlled trial evaluated the efficacy of dual transcranial direct current stimulation (tDCS) in 74 patients with post-stroke cognitive impairment (PSCI).
A standardized framework resolves ambiguity in motor neuron loss across neurodegenerative diseases.
This systematic review and meta-analysis examined motor neuron loss in spinal muscular atrophy (SMA) mouse studies, highlighting a 60% variability in reported loss due to spinal cord sampling methods.
Paraneoplastic Myopathy as a Possible Initial Presentation of Sporadic Burkitt Lymphoma in an Immunocompetent Adult: A Case Report.
An immunocompetent adult male presented with acute progressive proximal muscle weakness and elevated creatine phosphokinase levels. Extensive evaluations ruled out autoimmune and metabolic causes.
Pulmonary arteriovenous malformation (PAVM) with hereditary haemorrhagic telangiectasia (HHT): a rare cause of paradoxical embolic stroke.
A woman in her 40s presented with right-sided hemiparesis, and MRI revealed a left thalamic infarction. Further investigation identified pulmonary arteriovenous malformation (PAVM) associated with hereditary…
Meningioma regression following discontinuation of depot medroxyprogesterone acetate.
Three patients with meningioma who were under active surveillance experienced tumor regression after discontinuing depot medroxyprogesterone acetate (dMPA).
Smoking and disability outcomes in multiple sclerosis: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the impact of smoking on disability outcomes in multiple sclerosis (MS) across 18 studies.
Whole-exome sequencing reveals a novel frameshift and a recurrent nonsense SPG11 variant causing rare familial amyotrophic lateral sclerosis type 5 in two consanguineous Pakistani families.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects both upper and lower motor neurons, disturbing communication between the brain and muscles.
Acute ischemic stroke revealing cryptococcal meningitis in an HIV-infected patient with a relatively preserved CD4 count: a case report.
A 28-year-old man with a long history of HIV presented with acute right-sided hemiparesis. Despite a CD4 count of 302 cells/mm³, brain imaging revealed an acute infarction in the left internal capsule and hydrocephalus.
The Prevalence of Neuropathic Pain in Multiple Sclerosis-A Systematic Review and Meta-Analysis Using the NeuPSIG Algorithm.
This systematic review and meta-analysis estimated the prevalence of neuropathic pain in multiple sclerosis (MS) using the NeuPSIG algorithm.
CSF Tau and Amyloid Biomarkers in Cognitive Impairment Across the ALS-FTD Spectrum: A Systematic Narrative Review and Evidence Map.
This systematic narrative review examined the associations between cerebrospinal fluid (CSF) tau and amyloid biomarkers and cognitive impairment in 638 participants across the ALS-FTD spectrum.
The WNT/β-catenin Pathway and Matrix Metalloproteinase-9 in hypermobile Ehlers-Danlos Syndrome and Autism Spectrum Disorder: A Possible Connection.
This narrative review explores the connection between hypermobile Ehlers-Danlos Syndrome (hEDS) and Autism Spectrum Disorder (ASD), highlighting their symptom overlap and comorbidity.
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