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751 articles
July 202615
The effect of mild and moderate hepatic impairment on the pharmacokinetics, safety and tolerability of balcinrenone.
This Phase I clinical trial evaluated the pharmacokinetics, safety, and tolerability of balcinrenone in individuals with mild and moderate hepatic impairment compared to those with normal hepatic function.
GIP contributes to postprandial regulation of splanchnic blood supply in humans with type 2 diabetes: a randomised, single-blinded, placebo-controlled, crossover study.
This randomized, single-blinded, placebo-controlled crossover study examined the role of endogenous glucose-dependent insulinotropic polypeptide (GIP) in postprandial splanchnic blood flow in ten individuals with type 2…
Blood-based microRNAs as biomarkers of insulin resistance in childhood obesity: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated blood-based microRNAs (miRNAs) as biomarkers for insulin resistance (IR) in children with obesity.
Per- and polyfluoroalkyl substances and the risk of thyroid and breast cancer: Evidence from a meta-analysis and computational toxicology.
This meta-analysis evaluated the association between per- and polyfluoroalkyl substances (PFAS) exposure and the risks of thyroid and breast cancer. The analysis included literature from January 2003 to May 2025.
Refractory hypercalcemia due to iatrogenic unintentional Vitamin D intoxication unmasked by pancreatitis: Lessons learnt from an atypical case.
A 64-year-old man presented with severe abdominal pain, vomiting, and symptoms of hypercalcemia, including polyuria and weight loss. Laboratory tests revealed significantly elevated calcium levels and renal impairment.
Efficacy and safety of a novel oral anti-vasculogenic mimicry agent, CVM-1118, in advanced well-differentiated neuroendocrine tumors: a Phase IIa trial.
This Phase IIa trial evaluated the efficacy and safety of CVM-1118 in 43 patients with advanced well-differentiated neuroendocrine tumors (NETs) who were refractory to standard therapies.
Effect of continuous energy restriction combined with probiotic supplementation on parameters related to homeostatic and hedonic systems of food intake in adult men living with obesity: Data from a randomized, parallel, double-blind, placebo-controlled clinical trial.
This randomized, double-blind, placebo-controlled trial evaluated the effects of continuous energy restriction (CER) combined with probiotic supplementation on appetite-related hormones and eating behaviors in adult men…
From fetal life to adulthood: cardiometabolic health of offspring conceived by assisted reproductive technologies, a systematic review.
This systematic review evaluated the cardiometabolic health of offspring conceived via assisted reproductive technologies (ART) across developmental stages.
Glucagon-Like Peptide-1 Receptor Agonists and Risk of Adverse Maternal Pregnancy Outcomes: A Systematic Review and Meta-analysis.
This systematic review and meta-analysis evaluated the impact of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) on maternal pregnancy complications in 186,598 pregnancies.
Reflections on GnRH analogues dosage in the context of escape phenomenon: a case report of hypothalamic hamartoma with central precocious puberty and literature review.
A 15-month-old boy with central precocious puberty due to hypothalamic hamartoma experienced an escape phenomenon during treatment with gonadotropin-releasing hormone analogues.
Impact of iGlarLixi on Glycaemic Control Depth and Variability in Asian Pacific People With Type 2 Diabetes: A Post Hoc Analysis of LixiLan-O-AP and LixiLan-L-CN.
This post hoc analysis of two phase 3 trials evaluated the effects of iGlarLixi on glycaemic control depth, variability, and postprandial glucose in Asian Pacific individuals with type 2 diabetes.
Efficacy and Safety of Intensifying Once-Weekly Insulin Icodec Treatment With Once-Weekly Semaglutide in Adults With Type 2 Diabetes: A Single-Arm, Open-Label, Treat-to-Target, Phase 3b Trial (ONWARDS 8).
The ONWARDS 8 trial evaluated the efficacy and safety of intensifying once-weekly insulin icodec with semaglutide in adults with type 2 diabetes.
Potential Mediators of Efpeglenatide's Cardiovascular Benefit: An Exploratory Analysis of the AMPLITUDE-O Trial.
This exploratory analysis of the AMPLITUDE-O trial evaluated potential mediators of efpeglenatide's cardiovascular benefits in 4,076 individuals with Type 2 diabetes and cardiovascular or kidney disease.
Exercise or Fasting in Individuals With Type 2 Diabetes Receiving Once-Weekly Basal Insulin Icodec.
This Phase I clinical trial evaluated glucose levels and hypoglycaemia risk in 30 adults with type 2 diabetes receiving once-weekly basal insulin icodec during exercise and fasting.
GLP-1 Receptor Agonists and Cardiovascular Outcomes in Patients with Type 2 Diabetes Across Myocardial Infarction-Defined Populations: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the impact of GLP-1 receptor agonists on cardiovascular outcomes in 37,393 patients with type 2 diabetes who had experienced myocardial infarction.
June 20269
Oat-Rich Low-Gluten Diet Modulates Plasma Short-Chain Fatty Acids without Significant Changes in Fecal Microbiome or Inflammatory Markers-A Randomized Clinical Trial in People with Cardiometabolic Risk.
This randomized controlled trial examined the effects of an oat-rich low-gluten diet (LGD) on plasma short-chain fatty acids (SCFAs), fecal microbiome, and inflammatory markers in 69 individuals with cardiometabolic…
Impact of Health Insurance Coverage on Diabetes Care Quality: A Systematic Review and Meta-analysis of Racial, Ethnic, and Gender Disparities in U.S. Adults with Type 2 Diabetes.
This systematic review and meta-analysis examined the impact of health insurance coverage on diabetes care quality among U.S. adults with type 2 diabetes.
Effects of Compassion Meditation on Psychological Status in Patients With Diabetes: A Pilot Randomized Controlled Trial.
This pilot randomized controlled trial evaluated the effects of a 4-week compassion meditation intervention on psychological factors in patients with type 1 or type 2 diabetes.
The Serum 25-Hydroxyvitamin D Response to Supplemental Vitamin D Is Temporarily Blunted with Elevated Circulating Cytokines at Baseline.
This randomized controlled trial investigated the impact of elevated baseline serum cytokines, particularly IL-6, on the serum 25-hydroxyvitamin D (25(OH)D) response to vitamin D supplementation in healthy adults and…
Effect of Retatrutide, a Novel Triple Receptor Agonist, on Blood Pressure and Lipid Levels: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
This systematic review and meta-analysis evaluated the effects of retatrutide, a triple receptor agonist, on blood pressure and lipid levels in randomized controlled trials.
Peripheral precocious puberty with unilateral ovarian agenesis in early childhood: a case report and review of literature.
A 2-year and 10-month-old girl presented with breast development, pubarche, and recurrent vaginal bleeding. Imaging revealed a cyst in the left ovary and agenesis of the right ovary.
Reassessing parathyroidectomy outcomes in kidney transplant recipients with hyperparathyroidism: A fragility-index focused review.
This systematic review assessed the outcomes of parathyroidectomy (PTX) timing in kidney transplant recipients with secondary hyperparathyroidism (SHPT).
Phentermine/Topiramate in Obese, Diabetic Uric Acid Stone Formers: An Open-Label Randomized Feasibility Trial.
This open-label randomized feasibility trial evaluated the effects of phentermine/topiramate on uric acid kidney stone burden in obese, diabetic patients.
Explaining blood pressure reduction heterogeneity in sodium-glucose cotransporter-2 inhibitor trials: a meta-analysis stratified by patient characteristics.
This meta-analysis assessed the blood pressure-lowering effects of sodium-glucose cotransporter-2 inhibitors (SGLT-2i) across 38 randomized controlled trials involving 48,828 patients.
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