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1022 articles
August 202624
Cognitive impairment in adult Alexander disease.
A 53-year-old man with genetically confirmed adult-onset Alexander disease presented with progressive cognitive and behavioral issues.
Circular RNAs in amyotrophic lateral sclerosis.
This systematic review investigates the role of circular RNAs (circRNAs) in amyotrophic lateral sclerosis (ALS) and related motor neuron diseases.
Neurological effects of encapsulated dexamethasone sodium phosphate in children aged 6-9 years with ataxia telangiectasia (NEAT): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.
The NEAT trial was a multicentre, randomised, double-blind, placebo-controlled phase 3 study assessing the efficacy and safety of encapsulated dexamethasone sodium phosphate (eDSP) in children aged 6-9 years with ataxia…
Uncommon Concurrent Retinal and Cerebral Metastasis in High-risk Neuroblastoma: Diagnostic Utility of 68Ga-DOTATATE PET/CT Despite Negative 18F-FDG PET/CT.
A 5-year-old girl with high-risk neuroblastoma presented for surveillance with an 18F-FDG PET/CT, which showed two metabolically silent lesions in the right retina and brain.
Biallelic SLC20A2 loss-of-function in severe early-onset neurodevelopmental disorder with brain calcification.
A child presented in early infancy with refractory seizures, severe hypotonia, left hemiplegia, profound developmental impairment, bilateral cataracts, and progressive intracranial calcification.
Downbeat nystagmus: a practical approach based on a clinical case.
Spontaneous downbeat nystagmus (DBN) is the most common form of acquired nystagmus, characterized by a slow upward ocular drift and a corrective downward quick phase.
Fulminant cryptococcal meningoencephalitis with adrenal involvement in an immunocompetent patient: a clinicopathologic correlation.
A 65-year-old immunocompetent man presented with severe headache, psychomotor agitation, confusion, and disorganized speech.
A 4-year-old male presenting with frequent falls, clumsily rising from seated positions, but a normal creatine kinase.
A 4-year-9-month-old boy had progressive gait instability, frequent falls, mild coordination impairment, and difficulty rising.
Individualized vs Standard Blood Pressure Control During Thrombectomy for Ischemic Stroke: The DETERMINE Randomized Clinical Trial.
The DETERMINE randomized clinical trial evaluated individualized blood pressure (BP) control during mechanical thrombectomy for ischemic stroke in 433 patients.
Heterogeneity in Teriflunomide Treatment Arms: A Systematic Review and Meta‑Regression of Randomised Multiple Sclerosis Trials.
This systematic review and meta-analysis examined temporal trends in relapse and disability outcomes in teriflunomide arms of Phase 3 trials for relapsing multiple sclerosis (RMS).
Safe administration of botulinum neurotoxin type A for facial nerve palsy sequelae in a patient with myasthenia gravis.
A woman in her 40s with a 10-year history of generalized, seronegative myasthenia gravis presented with facial tightness and mild synkinesis due to facial nerve palsy sequelae.
Two Japanese Cases Highlighting Structural and Phenotypic Overlap in AGO1- and AGO2-Related Neurodevelopmental Disorders.
Two unrelated Japanese individuals presented with global developmental delay, hypotonia, midface hypoplasia, thin upper lip, elongated facial shape, and reduced cerebral white matter volume.
Peroxisomal disorder associated with ACOX1 gain-of-function mimicking neuroinflammatory disease.
A 6-year-old girl presented with motor delay, ichthyosiform eczema, gait disturbance, pain, weakness, areflexia, hypomimia, and hearing loss.
Clinical efficacy and brain mechanism characteristics of guide chi and regulate spirit tuina therapy in the treatment of post-stroke walking dysfunction: A randomized controlled trial based on fNIRS.
This randomized controlled trial evaluated the efficacy of Guide Chi and Regulate Spirit (GCRS) Tuina therapy in improving walking function among post-stroke patients with walking dysfunction.
Effectiveness of hyperbaric oxygen in traumatic brain injury patients: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effectiveness of hyperbaric oxygen therapy (HBOT) in adults with traumatic brain injury (TBI).
Parkinsonism as a Potential Neurologic Immune-Mediated Adverse Event of Immune Checkpoint Inhibitors.
Immune checkpoint inhibitor (ICI)-related parkinsonism is an exceedingly rare neurologic immune-related adverse event (irAE).
Intramuscular midazolam versus intravenous clonazepam for prehospital treatment of generalized tonic-clonic seizures: A randomized double-blind non-inferiority trial.
This randomized double-blind non-inferiority trial evaluated the efficacy of intramuscular (IM) midazolam versus intravenous (IV) clonazepam for prehospital treatment of generalized tonic-clonic seizures in patients…
Multimodal circadian phenotyping reveals distinct mechanisms of photic entrainment failure in two sighted patients with non-24-hour sleep-wake disorder.
Two sighted patients with non-24-hour sleep-wake disorder (N24SWD) underwent extensive circadian phenotyping to explore mechanisms of photic entrainment failure.
Association between lipoprotein-associated phospholipase A2 levels and risk of recurrent cerebrovascular events in patients with ischemic stroke: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the relationship between lipoprotein-associated phospholipase A2 (Lp-PLA2) levels and recurrent cerebrovascular events in 2,527 patients with ischemic stroke.
Prognostic effect of serum glial fibrillary acidic protein and neurofilament light chain for predicting progression independent of relapse activity in multiple sclerosis: A systematic review.
This systematic review evaluated the prognostic value of serum glial fibrillary acidic protein (sGFAP) and neurofilament light chain (sNfL) in predicting progression independent of relapse activity (PIRA) in multiple…
Clinical Reasoning: A 79-Year-Old Man With Subacute Onset Involuntary Facial Movements and Discoordination.
A 79-year-old man with metastatic Merkel cell carcinoma undergoing cancer-directed treatment was admitted to the hospital with 1 week of bilateral upper and lower extremity tremor and nearly continuous involuntary…
Pearls & Oy-sters: Bilateral Neuropathic Facial Pain With Autonomic Features and Neurovascular Contact.
A 35-year-old woman presented with severe bilateral facial pain in the V1 and V2 distributions, exacerbated by cosmetic product use and following a viral upper respiratory infection.
Outcomes of Intra-Arterial Tenecteplase after Endovascular Reperfusion for Acute Ischemic Stroke Due to Cardioembolism and Non-Cardioembolism: A Secondary Analysis of the POST-TNK Trial.
This secondary analysis of the POST-TNK randomized trial evaluated the safety and efficacy of intra-arterial tenecteplase (TNK) in 540 patients with acute ischemic stroke (AIS) due to cardioembolism (CE) and non-CE.
Spectrum of Neurofascin-155 Autoimmune Nodopathy in a Pediatric Cohort: A Single Center Experience.
This single-center pediatric case series described four patients with anti-neurofascin-155 autoimmune nodopathy. All had distal weakness and sensory loss; three also had tremor and sensory ataxia.
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