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1821 articles
August 202624
Patient-reported outcomes with tarlatamab in extensive-stage small cell lung cancer after platinum-based chemotherapy: results from the phase 3 DeLLphi-304 trial.
The phase 3 DeLLphi-304 trial evaluated patient-reported outcomes (PROs) in adults with extensive-stage small cell lung cancer (ES-SCLC) receiving tarlatamab versus standard-of-care chemotherapy after platinum-based…
A phase 2 study of encorafenib in combination with binimetinib for Chinese participants with BRAF V600E mutated metastatic non-small cell lung cancer: Results from the OCEAN II study.
The OCEAN II study, a phase 2 clinical trial, evaluated the efficacy and safety of encorafenib combined with binimetinib in 63 Chinese participants with BRAF V600E-mutated metastatic non-small cell lung cancer.
SYS6010, epidermal growth factor receptor-targeting antibody-drug conjugate for advanced non-small cell lung cancer: A phase 1 trial.
This phase 1 trial evaluated SYS6010, an antibody-drug conjugate targeting EGFR, in 236 patients with advanced non-small cell lung cancer (NSCLC).
Distress Intolerance: Dialectical Behavior Therapy Informed Communication for Serious Illness Care.
A patient with advanced cancer exhibited significant emotion dysregulation and low distress tolerance, impacting their communication with the medical team and causing distress among clinicians.
Comparison of the outcomes of ileal pouch-anal anastomosis and ileorectal anastomosis for patients with familial adenomatous polyposis: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated outcomes of ileal pouch-anal anastomosis (IPAA) versus ileorectal anastomosis (IRA) in 4700 patients with familial adenomatous polyposis.
Axillary Surgery in Sentinel Node-Positive Breast Cancer After Neoadjuvant Therapy: A Systematic Review and Meta-analysis.
This systematic review and meta-analysis evaluated the outcomes of axillary lymph node dissection (ALND) versus omission of ALND in patients with sentinel node-positive breast cancer after neoadjuvant therapy.
Immune checkpoint inhibitors in the management of oral mucosal melanoma.
Oral mucosal melanoma (OMM) is a rare, aggressive malignancy biologically distinct from cutaneous melanoma. Given complex anatomy and limited chemotherapy efficacy, immune checkpoint inhibitors (ICIs) are increasingly…
Intestine as the Exclusive Site of Distant Metastasis From Lung Adenocarcinoma Detected on 18 F-FDG PET/CT.
A 77-year-old man with lung adenocarcinoma underwent 18F-FDG PET/CT, which showed a moderately hypermetabolic pulmonary nodule and two intensely hypermetabolic intestinal lesions.
COMBI-I: Long-Term Overall Survival With Spartalizumab Plus Dabrafenib and Trametinib in BRAF V600-Mutant Advanced Melanoma.
The COMBI-I trial, a randomized controlled trial, assessed the efficacy of spartalizumab combined with dabrafenib and trametinib in 267 patients with BRAF V600-mutant advanced melanoma.
Matching-adjusted indirect comparison of fruquintinib versus ramucirumab in advanced gastric or gastroesophageal junction adenocarcinoma.
This study conducted a matching-adjusted indirect comparison of fruquintinib plus paclitaxel versus ramucirumab plus paclitaxel in patients with advanced gastric or gastroesophageal junction adenocarcinoma.
Positive Margin Rate Following Transoral Surgery in T2-T3 Laryngeal Carcinoma - a Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the positive margin rate following transoral endoscopic surgery in 3,281 patients with T2-T3 laryngeal carcinoma.
Response-adapted surgical de-escalation following neoadjuvant immunotherapy in resectable mucosal HNSCC A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the safety and efficacy of response-adapted surgery (RAS) following neoadjuvant immunotherapy in 202 patients with resectable mucosal head and neck squamous cell…
Metastatic Breast Cancer to the Cervix and Endometrium Mimicking a Primary Gynecologic Malignancy.
A 56-year-old postmenopausal woman with a history of metastatic invasive mammary carcinoma presented after experiencing heavy vaginal bleeding and a syncopal event.
MicroRNAs in IPF and lung cancer: convergent and divergent mechanisms: a systematic review.
This systematic review examines the role of microRNAs (miRNAs) in idiopathic pulmonary fibrosis (IPF) and lung cancer (LC), highlighting shared and distinct mechanisms.
SSTR Antagonist PET/CT Unveils Occult Hepatic Metastases in Rectal Neuroendocrine Tumor: Superiority Over 68 Ga-DOTANOC and Clinical Upstaging.
68 Gallium NODAGA-JR11, a somatostatin receptor (SSTR) antagonist, exhibits superior sensitivity in detecting hepatic metastases of neuroendocrine tumors compared with the agonist tracer 68 Ga-DOTANOC PET/CT.
Multiple Radioiodine-avid Skin Metastases From Thyroid Carcinoma Detected on Posttherapy 131 I SPECT/CT.
A 77-year-old man with papillary thyroid carcinoma had achieved remission after radioactive iodine treatment for metastatic disease.
Multitarget Molecular Imaging-based Characterization of Gastrointestinal Stromal Tumor.
An incidental gastric gastrointestinal stromal tumor (GIST) was identified and evaluated using three separate PET radiopharmaceuticals.
Personalized Sedation Goals for Agitated End-of-Life Delirium: Secondary Analysis of RECORD Trial.
This preplanned secondary analysis of a multicenter, double-blind randomized trial assessed whether treatments achieved caregiver-defined personalized sedation goals in patients with advanced cancer and persistent…
Artificial intelligence-supported double reading in European population breast cancer screening: A systematic review and meta-analysis of prospective programs.
This meta-analysis evaluated the impact of artificial intelligence (AI) on breast cancer screening in European populations, synthesizing data from three large studies.
From human papillomavirus (HPV) infection to HPV-associated cancers in systemic lupus erythematosus: A systematic review and Meta-analysis.
This systematic review and meta-analysis evaluated the risk of HPV infection and associated cancers in patients with systemic lupus erythematosus (SLE).
Stage shift, histological differentiation, and survival patterns of lung squamous cell carcinoma versus adenocarcinoma in low-dose CT screening.
This randomized controlled trial compared stage shift, histological differentiation, and survival patterns between lung squamous cell carcinoma (LUSC) and adenocarcinoma (LUAD) in low-dose CT (LDCT) screening.
The effects of mindfulness-based cognitive therapy in the psychological and physical health of cancer patients: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effects of mindfulness-based cognitive therapy (MBCT) on psychological and physical health in cancer patients.
Biomarker-Stratified Phase II Trial of Trastuzumab Rezetecan in Advanced Salivary Gland Carcinoma Across Cohorts With High and Low Human Epidermal Growth Factor Receptor 2 Expression.
This phase II trial evaluated trastuzumab rezetecan in patients with unresectable advanced salivary gland carcinoma (SGC), stratified by HER2 expression levels.
Autologous dermal flap techniques beyond inferior dermal flap coverage in implant-based breast reconstruction: A systematic review.
While inferior dermal flap (IDF) techniques are gaining popularity for implant-based reconstruction (IBBR), a range of autologous dermal flap (ADF) modifications have been described that serve purposes beyond standard…
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