Trending archive
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1821 articles
August 202616
Artificial intelligence for anticancer drug discovery from natural products of macroalgae and sponges: A systematic review.
This systematic review examines the role of artificial intelligence (AI) in the discovery of anticancer drugs from marine natural products (MNPs) derived from macroalgae and sponges.
Darolutamide Alone and in Combination With Goserelin in Androgen Receptor-Positive Salivary Gland Carcinoma: Results From the Phase II DISCOVARY Trial.
The phase II DISCOVARY trial evaluated darolutamide, both alone and with goserelin, in patients with androgen receptor-positive unresectable locally advanced or recurrent/metastatic salivary gland carcinoma.
Safety and Efficacy of Psilocybin During Anticancer Treatment: A Phase II Trial Secondary Analysis.
This phase II trial secondary analysis evaluated the safety and efficacy of psilocybin-assisted therapy in cancer patients with major depressive disorder, comparing those receiving systemic anticancer treatment to those…
Surgical Management of Young Women with High-Risk Breast Cancer Receiving Neoadjuvant Systemic Therapy on the I-SPY2 Trial.
This secondary analysis of a multicenter clinical trial compared surgical management and outcomes by age among patients with high-risk, stage II–III breast cancer who received neoadjuvant systemic therapy.
Metastatic Gastrointestinal Neuroectodermal Tumor Mimicking a Benign Hepatic Hemangioma on MRI: Role of 18 F-FDG PET/CT.
A 27-year-old man with proximal jejunal gastrointestinal neuroectodermal tumor (GNET) underwent segmental resection and adjuvant chemotherapy.
FAPI-negative Papillary Renal Cell Carcinoma With Markedly FAPI-avid Sacral Insufficiency Fracture.
A 77-year-old woman with papillary renal cell carcinoma underwent [68Ga]Ga-FAPI imaging. The primary tumor showed no increased FAPI uptake, but intense uptake in the sacrum raised concern for bone metastasis.
Systematic review on associations of cancer-related fatigue with proinflammatory cytokines: IL-1alpha, IL-1beta, IL-6, TNF-alpha.
This systematic review examined associations between cancer-related fatigue and IL-1α, IL-1β, IL-6, and TNF-α in original studies of adults with cancer.
Neoadjuvant Chemoradiotherapy Versus Chemotherapy in Patients with Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-analysis of Randomised Controlled Trials.
This systematic review and meta-analysis of randomised controlled trials compared neoadjuvant chemoradiotherapy (NACR) with neoadjuvant chemotherapy (NAC) in patients with pancreatic ductal adenocarcinoma.
Primary Cutaneous Anaplastic Large Cell Lymphoma in a Patient With Li Fraumeni Syndrome.
A 64-year-old man with Li-Fraumeni syndrome and a germline TP53 p.R196* mutation presented with a solitary ulcerated nodule on the left anterior thigh.
Treatment of Hot Flashes in Men With Prostate Cancer Undergoing Androgen Deprivation Therapy.
This systematic review evaluated pharmacological and non-pharmacological interventions for treating hot flashes in men with prostate cancer undergoing androgen deprivation therapy.
Global and regional prevalence, temporal trends, and projected trends of stroke after left ventricular assist device implantation: a systematic review and meta-analysis of 132,869 patients from 16 countries.
This systematic review and meta-analysis examined the prevalence of stroke following left ventricular assist device (LVAD) implantation across 132,869 patients from 16 countries.
Prophylactic folinic acid prevents pemetrexed myelosuppression: A randomized trial toward safer treatment with chemotherapy in non-small cell lung cancer.
This randomized controlled trial evaluated the effect of folinic acid prophylaxis on myelosuppression in 50 patients with non-small cell lung cancer receiving pemetrexed.
Exposure-Response Analyses to Inform the Optimal Epcoritamab Monotherapy Dosing Regimen in Relapsed or Refractory Follicular Lymphoma.
This phase I/II clinical trial evaluated the dosing regimen of epcoritamab in patients with relapsed or refractory follicular lymphoma.
Blinatumomab versus chemotherapy in pediatric B-ALL: A meta-analysis of randomized trials in relapsed and high-risk frontline disease.
This meta-analysis evaluated the efficacy of blinatumomab compared to chemotherapy in pediatric patients with relapsed/refractory or high-risk frontline B-cell acute lymphoblastic leukemia (B-ALL).
Latitude, seasonality, and circadian determinants of outcomes of systemic cancer therapy: Evidence from chemotherapy, immunotherapy, and chemo-immunotherapy combinations. A systematic review.
This systematic review evaluated the impact of treatment timing, seasonality, geographic latitude, and vitamin D status on the efficacy and toxicity of systemic cancer therapies.
A Systematic Review and Meta-Analysis of the Prognostic Value of Tumor Response Measurements During Radiotherapy for Head and Neck cancers.
This systematic review and meta-analysis evaluated the prognostic value of in-treatment tumor response measurements during radiotherapy for head and neck cancer, analyzing 98 studies.
July 20268
Clinical, Histopathological, and Molecular Characterization of Pediatric MN1::ZNF341-Associated Cancer.
A lethal round-cell malignancy with an MN1::ZNF341 fusion has recently been reported in three infants. Here, we describe four further tumors, three in newborns (including monozygotic twins), and one in an adolescent.
A novel neoadjuvant immunotherapy confers improved overall survival in oral cancer patients with low tumor PD-L1 expression The IT-MATTERS Clinical trial - Prognostic role of tumor PD-L1 expression.
This Phase III randomized controlled trial evaluated the impact of neoadjuvant Leukocyte Interleukin Injection (LI) combined with CIZ on overall survival (OS) in patients with low-risk oral squamous cell carcinoma…
Incidence of retropharyngeal lymph node involvement in oropharyngeal squamous cell carcinoma: a systematic review and meta-analysis.
This systematic review and meta-analysis examined the incidence of retropharyngeal lymph node (RPN) involvement in oropharyngeal squamous cell carcinoma (OPSCC) across 14 studies involving 8,887 patients.
Encorafenib plus binimetinib for BRAF V600-mutated thyroid cancer in Japan: final analysis.
This multicenter, open-label phase 2 trial assessed the efficacy and safety of encorafenib plus binimetinib (ENC + BIN) in 22 patients with unresectable BRAF V600-mutated thyroid cancer.
Near-complete Response of Bilateral Adrenal Metastases to 177Lu-PSMA Therapy in Castration-resistant Prostate Cancer on Posttherapeutic SPECT-CT Follow Up.
A 72-year-old man with castration-resistant prostate adenocarcinoma underwent 68Ga-PSMA-11 PET/CT for restaging due to significantly increased PSA levels during chemotherapy.
Symptom-guided reduction of BCG dwell time: findings from the north-REG randomized trial.
The multinational North-REG randomized controlled trial evaluated whether symptom-guided reductions in Bacillus Calmette-Guérin (BCG) dwell time could lessen toxicity in patients with non-muscle invasive bladder cancer.
Dexamethasone-Free Antiemetic Prophylaxis for Children and Adolescents Receiving Highly Emetogenic Chemotherapy: A Multicenter, Phase III, Noninferiority Trial (CIVIC POD).
The CIVIC POD trial evaluated the efficacy of olanzapine versus dexamethasone for preventing chemotherapy-induced nausea and vomiting in children aged 4-18 receiving highly emetogenic chemotherapy.
The Effect of Melatonin on Sleep Quality, Anxiety, and Depression in Patients with Primary Breast Cancer Undergoing Adjuvant Chemotherapy Type: A Randomized, Double-Blind, Placebo-Controlled Trial.
This randomized, double-blind, placebo-controlled trial evaluated the effects of melatonin on sleep quality, anxiety, and depression in 40 patients with primary breast cancer undergoing adjuvant chemotherapy.
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