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1998 articles
October 202624
#aware.hiv Europe study: protocol for a stepped-wedge cluster randomised trial of a multimodal hospital-based implementation strategy targeting HIV indicator-condition-guided testing in European hospitals.
The #aware.hiv Europe study is a stepped-wedge cluster randomised trial conducted in 30 hospitals across ten European countries, aiming to improve HIV testing rates among patients with HIV indicator conditions.
Immune-related colitis following head and neck reconstructive surgery in a patient receiving long-term nivolumab.
A man with gastric cancer, receiving long-term nivolumab and prednisolone for immune-related myositis, underwent subtotal glossectomy for advanced tongue cancer. On postoperative day 4, he developed grade 3 diarrhoea.
Hernia, mesh, microbes, and phage promise: Mapping 35 years of evidence through a systematic review.
This systematic review examined published evidence on microbiology and outcomes of hernia mesh infections, including studies from 1990–2025. Of 584 studies meeting inclusion criteria, 32 contributed to meta-analysis.
A High-Energy Military Femoral Fracture With Multidrug-Resistant Infection: A Case Report.
A 37-year-old military man presented with a high-energy femoral fracture complicated by a multidrug-resistant infection. After multiple debridement procedures and the use of an external fixation device, he underwent…
Parenchymal Injury Caused by Complete Migration of a Bone of Japanese Horse Mackerel Within the Pancreatic Uncinate Process Through a Duodenal Diverticulum, Resulting in Sepsis and Multiple Pyogenic Liver Abscesses.
A 79-year-old man developed abdominal pain and fever three days after ingesting grilled Japanese horse mackerel. Imaging revealed a fish bone fully migrated into the pancreatic uncus through a duodenal diverticulum…
Iron or Multiple Micronutrient Powder Supplements With Malaria Chemoprevention in Rural Malawian Children: The IRMA Randomized Clinical Trial.
This randomized clinical trial evaluated the effects of iron supplements combined with malaria chemoprevention on cognitive outcomes in 6-month-old infants in rural Malawi.
TRICALS risk score augments but cannot replace neurofilament as a prognostic biomarker in ALS.
This randomized controlled trial evaluated the TRICALS risk score as a prognostic tool in amyotrophic lateral sclerosis (ALS) using data from the MIROCALS trial (n = 220).
Standardized Acupuncture Plus Modified Xiaoxuming Decoction for Acute Ischemic Stroke: A Randomized Controlled Trial.
This single-center, assessor-blinded randomized controlled trial enrolled adults with imaging-confirmed acute ischemic stroke within 72 hours and compared standard care with or without standardized acupuncture plus…
Minimally Invasive Versus Sternotomy in Redo Mitral Valve Surgery: Short- and Long-Term Outcomes with Meta-Regression and Time-to-Event Analysis.
This meta-analysis compared minimally invasive mitral valve surgery (MI-MVS) with sternotomy for redo surgery in adults. It included 15 studies and 3457 patients, pooling perioperative outcomes and reconstructing…
Preoperative CA15-3 as a predictor of axillary lymph node metastasis and prognosis in women with breast cancer: a GRADE-assessed systematic review and meta-analysis.
This GRADE-assessed systematic review and random-effects meta-analysis examined cohort studies of preoperative CA15-3 in women with breast cancer, assessing survival and metastatic outcomes.
Drug treatments for fibromyalgia: systematic review and network meta-analysis of randomised trials.
This systematic review and network meta-analysis compared drug treatments for fibromyalgia in adults, including evidence from 151 randomised trials involving 32 592 participants.
A phase III randomized study: Immunogenicity and safety of a quadrivalent meningococcal conjugate vaccine in healthy adults, adolescents, and children in India and healthy adolescents and children in South Africa.
This Phase III randomized controlled trial assessed the immunogenicity and safety of a single dose of MenACYW-TT in healthy adults, adolescents, and children in India and in adolescents and children in South Africa.
Impact of opioid-free general anesthesia with locoregional blocks during breast cancer surgery on systemic inflammatory response: results from a randomized controlled trial.
This randomized controlled trial evaluated the effects of opioid-free general anesthesia with locoregional blocks (OfGA) versus traditional opioid-based general anesthesia (GA) on postoperative inflammation in breast…
Feeding following cleft palate surgery: a prospective randomized clinical trial comparing suprazygomatic maxillary nerve block and greater palatine nerve block.
This randomized controlled trial evaluated the effectiveness of suprazygomatic maxillary nerve blocks (SZMNB) versus greater palatine nerve blocks (GPNB) in children aged 1-10 undergoing cleft palate surgery.
Cardiac arrest revealing an occult interventricular septal hydatid cyst in a child.
An 11-year-old girl experienced sudden cardiac arrest during a biopsy of a dorsal hydatid cyst. After resuscitation, echocardiography revealed a 5.3 × 4.6 cm cyst in the interventricular septum, with CT showing liver…
Clinical utility of randomized controlled trials of regional anesthesia for lower-extremity surgery: a systematic review.
This systematic review evaluated the clinical utility and transparency of randomized controlled trials (RCTs) on regional anesthesia (RA) for lower-extremity surgeries.
Assessing the completeness of safety reporting in clinical trials of regional anesthesia interventions: a registry-publication comparison systematic review.
This systematic review evaluated the completeness of adverse event (AE) reporting in interventional regional anesthesia trials registered on ClinicalTrials.gov and their corresponding publications.
Comparative Ultrasound Assessment of Standard and Wire-Core Airway Bougie Introducers in a Cadaver Model.
This randomized controlled trial evaluated the accuracy of point-of-care ultrasound (POCUS) in identifying standard bougie (SB) versus wire-core bougie (WCB) placements in cadaver models.
Chestnut flour-enriched bread reduces postprandial glycaemic response in healthy adults: a randomised, controlled crossover study.
This randomized controlled crossover study evaluated the impact of chestnut flour-enriched bread on postprandial glycaemic responses in fourteen healthy adults.
Nutraceuticals and phytoceuticals in the treatment of bipolar disorder: A systematic review and network meta-analysis.
This systematic review and network meta-analysis assessed randomized controlled trials of nutraceuticals and phytoceuticals for bipolar disorder. Twenty-eight trials involving 2,222 participants evaluated 22 treatments.
Caudal versus penile block and urethrocutaneous fistula formation following hypospadias repair in children <2 years: a multicenter randomized clinical trial.
This multicenter randomized controlled trial evaluated the incidence of urethrocutaneous fistula (UCF) formation in children under 2 years undergoing hypospadias repair with either caudal or penile block.
Geographical and temporal patterns of cutaneous leishmaniasis in Pakistan: insight from a decade of epidemiology.
This systematic review examined the geographical distribution and epidemiological trends of cutaneous leishmaniasis (CL) in Pakistan from 2014 to 2024.
Flavonoid-rich foods and vascular functions in healthy adults: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the effects of flavonoid-rich foods on vascular function in 561 healthy adults across 11 randomized controlled trials.
Systemic inflammatory response syndrome and adverse outcomes in acute intracerebral hemorrhage: a meta-analysis.
This meta-analysis evaluated the prognostic significance of systemic inflammatory response syndrome (SIRS) in 6,976 patients with acute intracerebral hemorrhage (ICH).
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