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406 articles
September 202624
Haloperidol for Hypoactive and Hyperactive Delirium in ICU Patients-A Post Hoc Bayesian Analysis of the AID-ICU Trial.
This post hoc analysis of the AID-ICU trial evaluated the effects of haloperidol on delirium subtypes in 987 ICU patients. Haloperidol was linked to more days alive out of hospital, with a 76.5% probability of greater…
Regulatory Mechanisms Within Multicellular Signaling Networks in Liver Ischemia-Reperfusion Injury: A Systematic Review Focusing on Cell-Type-Specific Interactions.
This systematic review examines the regulatory mechanisms within multicellular signaling networks involved in hepatic ischemia-reperfusion injury (HIRI).
Applications of the Early Warning Score as an outcome measure: a systematic review of methodologies.
This systematic review evaluated the use of Early Warning Scores (EWS) as outcome measures in interventional and comparative studies.
"A better system" - managing the adverse effects of prescribed medicines: Cluster-randomised controlled trial and process evaluation of the ADRe Profile in primary care.
This cluster-randomized controlled trial evaluated the ADRe Profile's effectiveness in managing adverse drug reactions among patients aged ≥65 on multiple long-term medications in primary care.
Monitoring strategies in adults eligible for pharmacological lipid-lowering therapy.
This Cochrane systematic review protocol aims to evaluate the effects of various laboratory monitoring strategies on treatment efficacy and safety in adults eligible for pharmacological lipid-lowering therapy.
On the optimal sodium correction rate in hyponatraemia and clinical outcome: a meta-analysis.
This meta-analysis examined the impact of sodium correction rates on mortality in patients with hyponatraemia, analyzing 11 studies with 27,672 cases.
Intractable hepatic hydrothorax eliminated by thoraco-peritoneal connection: A case report.
A 55-year-old female with alcoholic cirrhosis presented with hepatic hydrothorax, characterized by jaundice, anorexia, chest tightness, and shortness of breath.
Infective endocarditis presenting with myocardial infarction with non-obstructive coronary arteries: A case report and literature review.
A 52-year-old male on long-term hemodialysis presented with acute chest pain, shortness of breath, and sweating. Initial ECG showed ST-segment depression, and elevated troponin I levels indicated myocardial infarction.
Helcococcus kunzii as a rare etiological agent of spondylodiscitis partially managed with oral antibiotic therapy in a patient with diabetes mellitus: a case report.
A 62-year-old man with type 1 diabetes mellitus presented with severe lumbar pain, leading to a diagnosis of spondylodiscitis confirmed by MRI.
Wearable Sweat Biosensors for Inflammatory Biomarkers (CRP, IL-6 and TNF-α): A Systematic Review of Analytical and Clinical Evidence.
This systematic review evaluated the use of wearable sweat biosensors for monitoring inflammatory biomarkers (CRP, IL-6, TNF-α) in human studies.
Fatal Cutaneous Mucormycosis Initially Misdiagnosed as Necrotizing Fasciitis in an Uncontrolled Diabetic Patient: A Case Report Highlighting Diagnostic Delay.
A 64-year-old male with undiagnosed diabetes presented with altered consciousness and extensive necrotic lesions, initially diagnosed as bacterial necrotizing fasciitis.
Impact of a standardised music intervention on serum cortisol among sedated, mechanically ventilated adults in the intensive care unit: A randomised controlled trial.
This randomized controlled trial evaluated the impact of a standardized music intervention on serum cortisol levels in sedated, mechanically ventilated adults in the ICU.
Autocrine signaling may regulate exercise-induced interleukin-6 release from human skeletal muscle.
This randomized, double-blind, placebo-controlled trial examined tissue exchange of interleukin-6 (IL-6) and soluble IL-6 receptor (sIL-6R) during moderate-intensity cycling in 30 young, well-trained men.
Haemolytic anaemia and thrombocytopenia following phenobarbital therapy for alcohol withdrawal.
A man in his 50s was admitted for alcohol withdrawal and developed acute anaemia and thrombocytopenia shortly after starting phenobarbital.
Evolving idiopathic multicentric Castleman disease with thrombocytopenia, anasarca, fever/hyperinflammation, renal dysfunction and organomegaly presenting with severe hypoalbuminaemia, serositis and bicytopenia before lymphadenopathy.
A man in his early 60s presented with abdominal symptoms, severe hypoalbuminaemia, thrombocytopenia, and marked inflammation, without evident lymphadenopathy.
AI-Based Sepsis Prediction in Hospitalized Adults: Systematic Review, Subgroup Meta-Analysis, and Contextual Analysis of Clinical Burden.
This systematic review and meta-analysis evaluated machine learning (ML) and deep learning (DL) models for sepsis prediction in hospitalized adults, analyzing 34 studies.
Deterministic and stochastic interventions in reducing drug-drug interactions in inappropriate prescribing: A systematic review.
This systematic review evaluated interventions aimed at reducing drug-drug interactions (DDIs) in inappropriate prescribing, focusing on deterministic and stochastic models.
Efficacy and safety of zilebesiran in adults with hypertension: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the efficacy and safety of zilebesiran in 1,412 adults with mild to moderate hypertension.
Efficacy and safety of rozanolixizumab in severe fibromyalgia: a phase 2A randomised, double-blind, placebo-controlled, multicentre trial.
This phase 2A, multicentre, randomised, double-blind, placebo-controlled trial assessed rozanolixizumab in adults with severe fibromyalgia at seven sites in north west England.
Weight Reduction Heterogenicity and Mediators of GLP-1RAs and Dual Agonists for Individuals With Obesity: A Meta-Analysis.
This meta-analysis examined the weight loss effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and dual agonists in 40,408 participants across 32 trials.
Men's experiences of multiple long-term conditions and/or disability in the UK Game of Stones weight management trial: a mixed-methods evaluation.
This mixed-methods evaluation within the Game of Stones randomized controlled trial examined the experiences and health outcomes of 585 men with obesity, focusing on those with multiple long-term conditions (MLTCs)…
Pheochromocytoma Masquerading as Acute Coronary Syndrome Complicated by Cardiogenic Shock: A CARE-Compliant Case Report.
A 59-year-old man with a history of intermittent chest tightness presented with acute cardiogenic shock, elevated troponin levels, and reduced left ventricular ejection fraction.
Integrated Telehealth Rehabilitation and Quality of Life in Mechanically Ventilated Adults: A Randomized Clinical Trial.
This randomized clinical trial evaluated the impact of an integrated telehealth rehabilitation program on health-related quality of life in 1916 adults with acute hypoxemic respiratory failure requiring mechanical…
Efficacy and Safety of Celecoxib Combined With Jintiange Capsules for the Treatment of Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
This randomized, double-blind, placebo-controlled trial assessed the efficacy and safety of celecoxib combined with Jintiange capsules in 120 patients with knee osteoarthritis (KOA).
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