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1333 articles
September 202624
Lacosamide effects on pain management in patients with multiple sclerosis: A randomized, double-blind, placebo-controlled clinical trial.
This randomized, double-blind, placebo-controlled trial assessed lacosamide for moderate-to-severe MS-related pain in adults with definite multiple sclerosis.
Retatrutide in adults with obesity and type 2 diabetes (TRIUMPH-2): a double-blind, parallel-group, randomised, placebo-controlled, phase 3 trial.
TRIUMPH-2 was a double-blind, parallel-group, randomised, placebo-controlled phase 3 trial at 92 centres in eight countries. It assessed once-weekly retatrutide in adults with obesity and type 2 diabetes.
The effects of dual-task training with different task priorities on physical performance and cognitive status in patients with Parkinson's disease: a single-blind, randomized controlled trial.
This randomized controlled trial investigated the effects of variable-priority dual-task training (V-DTT) and fixed-priority dual-task training (F-DTT) on physical performance and cognitive status in 30 patients with…
Epigenetic Programming of Stress-Response Systems: A Systematic Review of How Early Life Stress Shapes Developmental Trajectories of Mental Health.
This systematic review examines how early life stress (ELS) influences mental health development through epigenetic mechanisms, particularly DNA methylation, in 14 empirical human studies.
Acceptability and Feasibility of a Virtual Family-Based Single-Session Intervention for Young Teens at High Risk for Substance Use Disorder: Single-Arm Pilot Trial.
This single-arm pilot trial evaluated a virtual family-based single-session intervention (SSI) for young teens aged 12-14 at high risk for substance use disorder (SUD).
Real-world evaluation of 2023-2024 XBB.1.5 mRNA and protein-based COVID-19 vaccine reactogenicity from the randomized BEEHIVE trial.
This randomized controlled trial evaluated the reactogenicity of the 2023-2024 XBB.1.5 mRNA and protein-based COVID-19 vaccines in participants with prior mRNA vaccination.
Systolic blood pressure targets after successful endovascular thrombectomy: a network meta-analysis of randomized controlled trials.
This network meta-analysis evaluated the impact of different systolic blood pressure (SBP) targets on outcomes after endovascular thrombectomy in eight studies.
Exploring treatment moderators in a randomized clinical trial of virtual reality-based vs. standard cognitive behavioral therapy for paranoia.
This randomized clinical trial secondary analysis explored whether clinical and sociodemographic characteristics moderated response to virtual reality-based cognitive behavioral therapy for psychosis (VR-CBTp) versus…
Subcutaneous infliximab for maintenance therapy in children and adolescents with inflammatory bowel disease: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effectiveness and safety of subcutaneous infliximab for maintenance therapy in children and adolescents with inflammatory bowel disease.
Hypofractionated versus conventional fractionated postmastectomy radiotherapy for patients with high-risk breast cancer (CHN HYPOPMRT): 10-year outcomes from a randomised, non-inferiority, open-label, phase 3 trial.
This phase 3 randomized trial compared hypofractionated (43.5 Gy in 15 fractions) and conventional (50 Gy in 25 fractions) postmastectomy radiotherapy in 810 women with high-risk breast cancer.
Heart rate variability suppression in cancer patients versus non-cancer controls: a systematic review and meta-analysis.
This systematic review and meta-analysis examined heart rate variability (HRV) in cancer patients compared to non-cancer controls, including 28 studies with 3232 participants.
Diagnostic yield of Franseen biopsy needles in endoscopic ultrasound-guided tissue acquisition: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the diagnostic performance of Franseen biopsy needles compared to standard needles in endoscopic ultrasound-guided tissue acquisition among adult patients.
Effects of pulmonary rehabilitation on lung hyperinflation in patients with COPD: A systematic review and meta-analysis.
This systematic review and meta-analysis assessed whether pulmonary rehabilitation (PR) affects static and dynamic lung hyperinflation in people with COPD.
Vascular effects of dietary nitrate supplementation in older adults with coronary artery disease: A randomized, placebo-controlled, crossover pilot trial.
This randomized, double-blind, placebo-controlled crossover pilot trial assessed the safety, feasibility, and vascular effects of beetroot-derived dietary nitrate in eight older adults with confirmed coronary artery…
A systematic and critical review of measurement scales for evaluating gastrointestinal symptoms during exercise.
This systematic review evaluated 126 studies on measurement scales for gastrointestinal symptoms (GIS) during exercise, focusing on Likert-type and visual analog scales (VAS).
Deep learning for cardiac CT segmentation for congenital heart disease: A systematic review.
This systematic review evaluates deep learning (DL) approaches for cardiac CT segmentation in congenital heart disease (CHD), analyzing 14 studies.
Efficacy and safety of T-DXd versus Other HER2-targeted therapies in second-line and later settings for HER2-positive metastatic breast cancer: A Bayesian network meta-analysis.
This Bayesian network meta-analysis evaluated the efficacy and safety of T-DXd compared to other HER2-targeted therapies in 3,339 patients with HER2-positive metastatic breast cancer after trastuzumab-based therapy.
Exploring the relationship between HIV Testing frequency and sexual behavior, prevention prophylaxis use among MSM in Southern China.
This randomized controlled trial investigated the relationship between HIV testing frequency, sexual behaviors, and prophylaxis use among 327 men who have sex with men (MSM) in Guangxi, China.
Short-term nasal decongestant as bridge therapy with intranasal corticosteroids in children with persistent allergic rhinitis: A randomized controlled trial.
This prospective, open-label, single-centre randomised trial compared intranasal corticosteroid (INS) alone with INS plus five days of oxymetazoline in children aged 4–17 years with moderate-to-severe persistent…
Sirolimus Versus Paclitaxel Drug-Coated Ballons for Femoropopliteal Disease: The LIMUS FLOW Trial.
The LIMUS FLOW proof-of-concept randomized controlled trial compared sirolimus-coated balloons (SCBs) with paclitaxel-coated balloons (PCBs) for severe femoropopliteal peripheral artery disease in 70 patients.
Blood Pressure Dipping Status in Chronic Kidney Disease and Association With Adverse Outcomes: A Systematic Review and Meta-Analysis.
This systematic review and random-effects meta-analysis examined nondipping blood pressure prevalence, its association with CKD, and outcomes among people with CKD.
Prevalence of Cerebellar Cognitive Affective Syndrome in Patients with Cerebellar Disorders: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the prevalence of cerebellar cognitive affective syndrome (CCAS) in patients with cerebellar disorders.
Associations between prenatal bisphenol S with gestational age and preterm birth: A systematic review and meta-analysis.
This systematic review and meta-analysis examined whether prenatal bisphenol S (BPS) exposure is associated with gestational age or preterm birth.
Incidence and Predictors of Complications After Transcatheter Aortic Valve Implantation According to VARC-3 Criteria: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis pooled 57 studies involving 73 588 patients undergoing transcatheter aortic valve implantation (TAVI), with complications classified using VARC-3 criteria.
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