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1845 articles
July 202624
OPTIM: a randomized phase II trial of nivolumab followed by nivolumab-ipilimumab or docetaxel at progression in recurrent/metastatic squamous cell carcinoma of the head and neck (OPTIM; AIO-KHT-0117).
OPTIM was a randomized phase II trial in adults with platinum-refractory recurrent or metastatic squamous cell carcinoma of the head and neck.
Splenic Granulomatous Lesions Mimicking Metastases on 18 F-FDG PET/CT in a Patient With Ovarian Cancer.
A 76-year-old woman with a history of ovarian cancer underwent 18 F-FDG PET/CT due to increased CA199 levels in routine surveillance.
Evaluating the diagnostic performance of exosome biomarkers for the detection of ovarian cancer: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the diagnostic performance of exosome biomarkers for ovarian cancer detection, analyzing 16 studies.
Anticancer, hepatoprotective, and mechanistic evidence of chlorogenic acid in liver cancer: A systematic review.
This systematic review evaluated the effects of chlorogenic acid (CGA) on liver cancer, analyzing 21 studies. CGA showed anticancer effects in preclinical models by inhibiting tumor cell proliferation and inducing…
Disease Stabilization with MEK Inhibitors in NF1-Associated Plexiform Neurofibromas: A Systematic Review and Meta-Analysis with Subgroup Analyses by Age and Study Design.
This systematic review and meta-analysis evaluated the efficacy and safety of MEK inhibitors in 769 patients with NF1-associated plexiform neurofibromas (PN).
Recurrent Metastatic Esthesioneuroblastoma: First-in-human α/β PRRT With Actinium-225/Lutetium-177-DOTA-LM3 SSTR Antagonist Achieving Partial Response After Failure of Lutetium-177-DOTATOC PRRT.
A 45-year-old woman with recurrent metastatic esthesioneuroblastoma, previously treated and symptomatic, received a novel peptide receptor radionuclide therapy (PRRT) using a somatostatin receptor antagonist labeled…
The laryngofissure approach for near-infrared photoimmunotherapy in laryngeal cancer: A novel larynx-preservation strategy.
A 67-year-old male with laryngeal cancer presented with hoarseness and was staged as cT2N2bM0, Stage IVA. After two years of concurrent chemoradiotherapy, he experienced local recurrence in the subglottic and posterior…
Survival Outcomes of Head and Neck Neuroendocrine Carcinoma: A Systematic Review.
This systematic review examined survival outcomes in patients with head and neck neuroendocrine carcinoma (HNNEC), focusing on tumor characteristics and treatment strategies.
Comparison of obecabtagene autoleucel versus an external control arm in adult patients with relapsed/refractory B-cell acute lymphoblastic leukemia.
The FELIX study evaluated the efficacy of obecabtagene autoleucel (obe-cel) in adults with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL) compared to historical controls.
A Phase 2 Trial of Intravesical Cabazitaxel, Gemcitabine, and Cisplatin for the Treatment of Nonmuscle-Invasive Bacillus Calmette-Guérin-Unresponsive Urothelial Carcinoma of the Bladder.
This single-center phase 2 trial evaluated sequential intravesical cabazitaxel, gemcitabine, and cisplatin in patients with BCG-unresponsive high-risk nonmuscle-invasive bladder cancer who refused or were ineligible for…
Safety and efficacy of immune checkpoint inhibitors as a bridge to allogeneic hematopoietic stem cell transplantation in classical Hodgkin lymphoma: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the safety and efficacy of immune checkpoint inhibitors (ICIs) as a bridge to allogeneic hematopoietic stem cell transplantation (allo-HCT) in patients with classical…
Artificial intelligence-assisted detection and optical differentiation of colorectal lesions in Lynch syndrome surveillance (CADLY2): a multicentre, open-label, randomised controlled superiority trial.
The CADLY2 trial evaluated the impact of computer-aided detection (CADe) on adenoma detection rates during surveillance colonoscopy in patients with Lynch syndrome.
Pesticide exposure and all health outcomes: An umbrella review of meta-analyses of observational studies.
This umbrella review systematically analyzed 53 meta-analyses of observational studies to evaluate the health outcomes associated with pesticide exposure.
Asciminib monotherapy in patients with BCR::ABL1 T315I-mutated chronic-phase chronic myeloid leukemia: phase 1 trial final results.
This phase 1 trial evaluated the long-term safety and efficacy of asciminib in 48 patients with BCR::ABL1 T315I-mutated chronic-phase chronic myeloid leukemia (CML-CP).
Impacts of oncological treatments on fertility: A systematic review.
This systematic review evaluated the impact of oncological treatments on fertility using murine models, analyzing 30 studies.
Comparative analysis of patient-derived organoids and patient-derived xenografts as avatar models for predicting response to anti-cancer therapy.
This systematic review and meta-analysis compared patient-derived xenografts (PDX) and patient-derived organoids (PDO) in predicting treatment response in cancer patients.
Comparison of long-term outcomes between liver transplantation and liver resection for intrahepatic cholangiocarcinoma: An updated systematic review and meta-analysis.
This systematic review and meta-analysis evaluated long-term outcomes of liver transplantation (LT) versus liver resection (LR) for intrahepatic cholangiocarcinoma (ICC) in 5478 patients.
Impact of palliative intervention on end-of-life outcomes for patients undergoing surgery for cancer.
This randomized controlled trial examined the impact of early palliative care on end-of-life outcomes in 235 patients undergoing curative surgery for abdominal cancer.
Phase I Dose-Escalation Study Combining Irinotecan-Loaded Drug-Eluting Bead Chemoembolization with Yttrium-90 Glass Microsphere Radioembolization in Colorectal Liver Metastases (DEBIR 90 Y).
This Phase I dose-escalation study evaluated the maximum tolerated dose (MTD) of yttrium-90 glass microspheres combined with irinotecan-loaded drug-eluting beads in patients with colorectal liver metastases.
Integrated Evaluation of Survival, Surgical Conversion, and Toxicity for Induction Therapy in Initially Unresectable Colorectal Liver Metastases: An Individual Patient Data Network Meta-analysis.
This network meta-analysis evaluated the efficacy of induction therapies for initially unresectable colorectal cancer liver metastases (CRLM) using individual patient data from seven randomized controlled trials…
Dose-reduced (24 Gy) involved-site radiotherapy combined with rituximab in early-stage non-gastric mucosa-associated lymphoid tissue lymphoma: a prospective phase II trial.
This prospective phase II trial evaluated the efficacy of 24 Gy involved-site radiotherapy combined with rituximab in 60 patients with early-stage non-gastric mucosa-associated lymphoid tissue lymphoma.
A Prospective, Multicenter Randomized Controlled Trial (RCT) of the da Vinci SP ® Surgical System versus Open Surgery in Nipple-Sparing Mastectomy (NSM) Procedures for Patients with Breast Cancer.
This multicenter randomized controlled trial compared robotic-assisted nipple-sparing mastectomy (rNSM) using the da Vinci SP® system to open nipple-sparing mastectomy (NSM) in women with early-stage breast cancer.
Thermal ablation versus liver resection for small colorectal liver metastases (≤ 3 cm): a systematic review and meta-analysis of randomized and propensity score-matched studies.
This systematic review and meta-analysis evaluated thermal ablation versus liver resection for small colorectal liver metastases (CRLM ≤ 3 cm) using data from seven studies.
Direct tumour-adipocyte contact / Stroma AReactive Invasion Front Area (TAC/SARIFA) predicts adverse outcome in colorectal cancer: a focused evidence synthesis and meta-analysis.
This focused evidence synthesis and meta-analysis assessed whether direct tumour-adipocyte contact, termed TAC/SARIFA, is associated with survival in colorectal cancer.
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