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1845 articles
July 202624
Systemic Treatment of Ovarian Cancer Recurrence: ASCO Living Guideline, Version 2026.1.0.
The ASCO Living Guideline provides updated recommendations for the systemic treatment of recurrent high-grade serous and/or endometrioid epithelial ovarian cancer.
Targeting TIME With Phytochemicals: A Promising Approach Against Lung Cancer.
This systematic review investigates the role of phytochemicals in targeting the tumour immune microenvironment (TIME) in lung cancer.
A young pregnant woman with oesophageal cancer who responded to carboplatin plus nab-paclitaxel therapy.
A 35-year-old woman in her fifth month of pregnancy presented with dysphagia and later dyspnea. MRI showed an 8 cm anterior mediastinal mass compressing the airway.
Association between autoimmune pancreatitis and pancreatic cancer: a case after long-term steroid therapy.
A 71-year-old man with autoimmune pancreatitis, diagnosed from elevated serum IgG4 and characteristic imaging, remained in remission during a 7-year course of steroid therapy.
From the archives of MD Anderson Cancer Center: Crystal-storing histiocytosis associated with B-cell lymphoma.
A 61-year-old man with a history of resected colon adenocarcinoma presented with a 5.5 cm right ureteral mass, hydronephrosis, lymphadenopathy, and splenomegaly.
Multimorbidity and the risk of all-cause, cardiovascular, and cancer mortality in the general population: A meta-analysis of population-based cohort studies.
This meta-analysis evaluated the impact of multimorbidity on all-cause, cardiovascular, and cancer mortality across 69 cohort studies involving over 22 million individuals.
Efficacy and Safety of Camrelizumab Combined with Concurrent Chemoradiotherapy in Locally Advanced Cervical Cancer: A Phase II Single-Arm Clinical Trial.
This phase II single-arm trial assessed the efficacy and safety of camrelizumab combined with concurrent chemoradiotherapy in 50 patients with locally advanced cervical cancer.
Germline testing in lung cancer: evidence of enrichment without a standardized selection strategy - a systematic review.
This systematic review examined the prevalence of pathogenic germline variants (PGVs) in lung cancer across 49 studies. It found a median prevalence of approximately 6% in unselected cohorts and 27% in selected cohorts…
Enfortumab vedotin monotherapy, enfortumab vedotin plus pembrolizumab, and immune checkpoint inhibitor-based neoadjuvant therapy for muscle-invasive bladder cancer: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the efficacy of neoadjuvant enfortumab vedotin (EV) monotherapy, EV plus pembrolizumab (EV+P), and immune checkpoint inhibitor (ICI)-based therapies in muscle-invasive…
Clinical evidence for immune cell-based therapy for head and neck cancer: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated immune cell-based therapy (ICT) in head and neck squamous cell carcinoma (HNSCC) across 30 studies involving 953 patients.
Results of intensifying radiation treatment in advanced laryngeal, hypopharyngeal (LH) and oropharyngeal cancers (OPC) using metabolic dose escalation strategies: (INTELHOPE).
This Phase II randomized controlled trial evaluated the efficacy of FDG-PET guided escalated radiation dosing (73.5 Gy) versus standard dosing (66 Gy) in patients with locally advanced p16-negative oropharyngeal and…
Ketamine for Cancer-Related Pain in Palliative Care: A Systematic Review of Clinical Use and Safety.
Ketamine has emerged as an adjuvant for opioid-refractory cancer-related pain in palliative care, but evidence remains limited.
Pembrolizumab-Chemotherapy Versus Pembrolizumab in Head and Neck Squamous Cell Carcinoma: A PD-L1 CPS-Stratified Analysis of Updated KEYNOTE-048 Data.
This randomized controlled trial analyzed updated data from KEYNOTE-048 to compare the efficacy of pembrolizumab-chemotherapy versus pembrolizumab monotherapy in patients with recurrent/metastatic head and neck squamous…
The association of dietary inflammation index (DII) and health-related outcomes: An umbrella review of systematic reviews.
This umbrella review examined the association between the dietary inflammatory index (DII) and various health outcomes, analyzing 90 systematic reviews and meta-analyses.
The clinical utility of magnetic resonance elastography in differentiating tumor recurrence from pseudoprogression in glioblastoma.
Glioblastoma (GBM) is the most common malignant primary brain tumor in adults with nearly universal progression despite aggressive treatment.
Inconsistent definitions of local control for stereotactic body radiation therapy for early-stage lung cancer - A systematic review.
This systematic review examined the definitions and assessments of local control (LC) following stereotactic body radiation therapy (SBRT) for early-stage non-small cell lung cancer (NSCLC).
Quality of life and cost-effectiveness of preoperative accelerated versus postoperative conventional radiotherapy for oral cavity cancer: Results from the randomised ARTSCAN 2 trial.
The ARTSCAN 2 randomized controlled trial evaluated the health-related quality of life (HRQoL) and cost-effectiveness of preoperative accelerated fractionation (AF) radiotherapy versus postoperative conventional…
Altered Busulphan Exposure Associated with Concomitant Omeprazole during Hematopoietic Stem Cell Transplantation Conditioning: A Two-Case Report.
Two adult patients with acute myeloid leukemia underwent conditioning with oral busulphan prior to hematopoietic stem cell transplantation.
Preclinical evidence for cytokine-based immunotherapy in pancreatic cancer treatment: A systematic review.
This systematic review assessed cytokine-based immunotherapy for pancreatic cancer, analyzing 46 preclinical studies. It found that targeting cytokines like TGF-β and IL-6 improved stromal remodeling, while…
From center to edge: Prognostic implications of spatial metabolic heterogeneity, normalized hotspot-to-centroid and perimeter distance, on PET imaging. A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the prognostic value of PET-derived spatial radiomic features, specifically normalized hotspot-to-centroid (NHOC) and normalized hotspot-to-perimeter (NHOP) distances…
Intracholecystic Papillary Neoplasm Mimicking High-Grade Dedifferentiation in a Patient With Neuroendocrine Tumor: The Value of Dual-Tracer PET/CT.
A 50-year-old man with weight loss and fatigue was diagnosed with a grade 2 pancreatic neuroendocrine tumor with liver metastases.
Randomized phase-II trial of surufatinib plus FOLFOX/FOLFIRI versus FOLFOXIRI as second-line therapy for metastatic colorectal cancer.
This randomized phase-II trial evaluated the efficacy and safety of surufatinib combined with doublet (FOLFOX/FOLFIRI) versus triplet (FOLFOXIRI) chemotherapy in patients with metastatic colorectal cancer (mCRC) who…
Autophagy potential of polyphenols in breast carcinoma: A systematic review.
This systematic review evaluated the effects of polyphenols on autophagy in breast cancer, analyzing 48 studies, including 40 in vitro and 8 in vivo.
Assessing time to symptomatic progression, a patient-relevant efficacy endpoint, in the MARIPOSA study in non-small cell lung cancer.
The phase 3 MARIPOSA study evaluated the efficacy of amivantamab and lazertinib versus osimertinib in patients with untreated, EGFR-mutated advanced non-small cell lung cancer.
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