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1845 articles
June 202624
Lutetium-177-PSMA I&T (Lu-PSMA) with radiosensitising capecitabine in patients with metastatic castration-resistant prostate cancer (mCRPC): results of phase Ia study.
This phase I trial evaluated the safety and maximum tolerated dose (MTD) of capecitabine combined with Lutetium-177-PSMA I&T (Lu-PSMA) in 12 men with metastatic castration-resistant prostate cancer (mCRPC).
Intermittent olaparib with neoadjuvant platinum-based chemotherapy in BRCA-mutated un-resectable ovarian cancer: the NUVOLA trial.
The NUVOLA trial, a phase II open-label study, evaluated the addition of olaparib to neoadjuvant chemotherapy in 36 patients with BRCA-mutated advanced epithelial ovarian cancer.
Assessing the performance of deep learning and hand-crafted radiomics models using MRI and ultrasound in predicting axillary lymph node status in breast cancer: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed deep learning (DL) and hand-crafted radiomics (HCR) models using MRI or ultrasound to predict axillary lymph node metastasis in breast cancer, with histopathology as the…
Impact of Surgical Delay on Breast Cancer Prognosis: Systematic Review and Meta-analysis.
This systematic review and meta-analysis evaluated the impact of surgical delays on survival in invasive breast cancer, analyzing data from 26 studies with 4,921,120 patients.
The Changing Landscape of Maintenance Therapy in Newly Diagnosed Multiple Myeloma: A Systematic Review With Network Meta-Analysis of the European Myeloma Network (EMN).
This systematic review and network meta-analysis evaluated maintenance therapies for newly diagnosed multiple myeloma. It found that lenalidomide, proteasome inhibitors, and CD38 antibodies improved progression-free…
Bridging the Gap from "Paper" to "Patient": An Overview and Quality Assessment of PET/CT-Based Radiomics for Prostate Cancer Using the Updated RQS 2.0.
This systematic review evaluated the methodological quality and clinical translation maturity of PET-based radiomics studies in prostate cancer using the updated Radiomics Quality Score (RQS 2.0).
Antidiabetic medications and the risk of bladder cancer in patients with diabetes mellitus: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the association between antidiabetic medications and bladder cancer risk in patients with type 2 diabetes mellitus. A total of 85 studies were included.
Performance of Survival Prediction Tools in Patients With Gastrointestinal Stromal Tumors: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated survival prediction tools for adults with primary gastrointestinal stromal tumors (GISTs), analyzing 47 studies.
Prognosis of ER-positive, HER2-negative postmenopausal early breast cancer patients based on response to neoadjuvant endocrine therapy and multigene assay results: findings from the NEOS trial.
This phase III clinical trial investigated the long-term prognosis of 226 postmenopausal women with ER-positive, HER2-negative early breast cancer based on their response to neoadjuvant endocrine therapy and multigene…
Diffuse Splenic Uptake on 99m Tc MDP Bone Scintigraphy Secondary to Transfusion-Related Hemosiderosis : Correlation With MRI Findings.
A 70-year-old woman with a past medical history of breast cancer is undergoing surveillance. She also had a history of repeated blood transfusions for refractory anemia caused by treated marrow metastatic disease.
Limb Compression Therapy and Chemotherapy-Induced Peripheral Neuropathy in Women With Gynecologic Cancers: A Prospective Self-Controlled Study(NEURO-GLOVE Trial).
This prospective, self-controlled study evaluated the effect of dual-site mechanical compression on chemotherapy-induced peripheral neuropathy (CIPN) in 76 women with gynecologic cancers receiving…
Journey Mapping of the Patient Experience from Diagnosis to End of Life in Lung Cancer: A Qualitative Meta-Synthesis.
This qualitative meta-synthesis examined the experiences of lung cancer patients from diagnosis to end of life, analyzing 13 studies.
Hilar lymph node involvement in pediatric liver cancer and its impact on outcomes: A systematic review.
This systematic review evaluated hilar lymph node involvement in pediatric liver cancer, analyzing data from eight studies involving 880 patients.
The Effect of Pain Catastrophizing on Acupuncture Treatment for Chronic Pain in Cancer Survivors.
This randomized controlled trial investigated the influence of pain catastrophizing (PC) on acupuncture outcomes in 266 cancer survivors with chronic pain.
Patient-Centric First-in-Human Dose Selection: An Ex Vivo Minimal Anticipated Biological Effect Level Approach for T-Cell Engagers in Multiple Myeloma.
This Phase I clinical trial investigated a novel ex vivo minimal anticipated biological effect level (MABEL) approach for determining the first-in-human (FIH) dose of forimtamig, a T-cell bispecific antibody for…
Two-Year Outcomes after Direct-to-Surgery in Good Prognosis Margin-Clear Stage II or III Rectal Cancer: The QuickSilver Study.
The QuickSilver Study, a phase II multicenter trial, evaluated 2-year oncologic outcomes in 139 patients with margin-clear Stage II or III rectal cancer who underwent direct low anterior resection without neoadjuvant…
Oncologic Outcomes After Liver Transplantation for Unresectable Colorectal Liver Metastases: A Systematic Review and Meta-Analysis of Proportions.
This systematic review and meta-analysis assessed oncologic outcomes in 92 patients with unresectable colorectal liver metastases who underwent liver transplantation.
Outcomes From the Multicenter ACCRU-LY-1804/CARiBOU TRIAL (Cytarabine, Acalabrutinib and Rituximab Integrated With Bortezomib-Based Outpatient Therapy) in 1st Line Mantle Cell Lymphoma.
The CARiBOU trial, a phase 2 multicenter study, evaluated a multitargeted first-line treatment for mantle cell lymphoma (MCL) in 41 previously untreated patients.
Divergent PET Tracer Avidity in Synchronous Sarcomatoid Carcinoma With Osteosarcomatous Differentiation and Adenocarcinoma of the Prostate: Insights From Dual-Tracer 68 Ga-PSMA and 18 F-FDG PET/CT Imaging.
A 76-year-old man with mildly elevated prostate-specific antigen (PSA, 5.44ng/mL) and a PI-RADS 5 lesion on multiparametric MRI underwent dual-tracer PET/CT.
Hepatic Inflammatory Pseudotumor Presenting as FDG-avid Liver Lesions in a Prostate Cancer Patient: A Diagnostic Pitfall on PET/CT.
A 70-year-old man with prostate cancer underwent contrast-enhanced CT for lesion characterization, which revealed two newly detected hepatic lesions suspicious for metastasis.
Becotatug vedotin for recurrent/metastatic nasopharyngeal carcinoma (Magic-M001): a multicenter, randomized trial.
This multicenter, randomized trial evaluated becotatug vedotin in patients with recurrent/metastatic nasopharyngeal carcinoma (NPC) after failure of ≥2 systemic therapies.
Gephyrin Neurological Autoimmunity.
Gephyrin is a postsynaptic scaffold protein essential for inhibitory neurotransmission. Gephyrin-immunoglobulin G (IgG) was reported, decades ago, in a single case of paraneoplastic stiff-person-like syndrome, but its…
Oncoptysis as the primary presentation of metastatic melanoma: A case report.
An 88-year-old female presented to the emergency department with cough and hemoptysis. She expectorated abnormal tissue, initially thought to be lung tissue.
Nail Langerhans Cell Histiocytosis: A Rare Case Series of Two Patients With Single-System and Multisystem Disease Presenting With Nail Lesions.
Two boys, aged 2 years and 19 months, developed nail abnormalities as the initial feature of Langerhans cell histiocytosis (LCH).
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