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1891 articles
May 202624
Results of a Phase 1 Open-Label, Dose-Escalation Study of Gene Therapy With AAV2-hAQP1 for Grade 2 and 3 Radiation-Induced Late Xerostomia and Parotid Gland Hypofunction.
This Phase 1 open-label, multicenter study evaluated the safety and efficacy of AAV2-hAQP1 gene therapy in 24 patients with grade 2 and 3 radiation-induced late xerostomia.
Efficacy and safety of durvalumab with or without tremelimumab in the treatment of metastatic non-small cell lung cancer: a meta-analysis of randomized controlled trials.
This meta-analysis evaluated the efficacy and safety of durvalumab with or without tremelimumab in 2726 patients with metastatic non-small cell lung cancer (NSCLC).
Lorlatinib versus crizotinib as first-line treatment for advanced ALK-positive non-small-cell lung cancer: 7-year update from the phase III CROWN study.
The phase III CROWN study evaluated lorlatinib versus crizotinib in treatment-naive patients with advanced ALK-positive non-small-cell lung cancer (NSCLC).
The Use of Ketamine for Depression in Cancer Patients: A Systematic Review of Efficacy, Safety, and Clinical Applications.
This systematic review evaluated the efficacy and safety of ketamine for treating depression in adult cancer patients. Analyzing 14 studies, it found that ketamine can provide rapid relief from depressive symptoms…
Micro- and nanoplastics in the human genitourinary system: oncological impact - a systematic review.
This systematic review evaluated the presence and impact of micro- and nanoplastics (MNPs) in human urinary and male reproductive tissues.
FDG-PET/CT Parameters for distinguishing high and low microsatellite instability in colorectal cancer: A systematic review and Meta-analysis.
This systematic review and meta-analysis evaluated the effectiveness of FDG-PET/CT parameters in distinguishing high microsatellite instability (MSI-H) from low microsatellite instability (MSI-L) in colorectal cancer…
Maintenance treatment and survival in patients with newly diagnosed diffuse large B cell lymphoma in the immunochemotherapy era: a systematic review and network meta-analysis.
This systematic review and network meta-analysis compared maintenance strategies after initial treatment in previously untreated patients with diffuse large B-cell lymphoma (DLBCL), using randomized trials.
Cortex on Fire: Infarct Mimicking Ictal.
A 65-year-old woman with treated small cell lung cancer presenting with recurrent stroke-like symptoms and seizures underwent FDG PET/CT and MRI. Brain MRI revealed diffusion restriction.
Comparison of the EORTC QLQ-EN24, FACT-En, and FEnSI-23 for assessing quality of life in endometrial cancer: a systematic review.
This systematic review compares three patient-reported outcome measures for assessing quality of life in endometrial cancer: EORTC QLQ-EN24, FACT-En, and FEnSI-23.
Laparoscopic Minimally Invasive Approach for Left Paracaval Retroperitoneal Schwannoma.
A 55-year-old man presented with an incidentally found retroperitoneal mass, identified as a 4 cm schwannoma via endoscopic ultrasound-guided biopsy.
The Use of Corticosteroid Treatment Protocols in Compressive Epidural Spinal Metastases: Current Practice and the Need for Consensus.
This systematic review evaluated corticosteroid treatment protocols in patients with compressive epidural spinal metastases.
Radiotherapy for newly diagnosed adult high grade gliomas in the Asia Pacific Region.
This systematic review examined radiotherapy protocols for newly diagnosed adult high grade gliomas (HGG) in the Asia Pacific region.
Diffuse Large B-Cell Lymphoma Presenting as a Thigh Mass: A Case Report.
A 76-year-old female presented with swelling and pain in her right thigh. Imaging revealed a soft-tissue mass that raised concerns for sarcoma.
Neoplasms in prune belly syndrome: A novel case of early-onset metastatic bladder carcinoma and systematic review of reported tumors.
A 33-year-old man with Prune Belly Syndrome (PBS) presented with metastatic muscle-invasive urothelial carcinoma. Despite advances in care for PBS, he developed this aggressive malignancy, which is noted to occur at…
Role of diffusion-weighted MRI in assessing Ewing sarcoma treatment response: Findings from a COG phase III trial.
This phase III multicenter trial evaluated the correlation between diffusion-weighted MRI measures and glucose metabolism in 21 patients with metastatic Ewing sarcoma.
Microsurgical treatment of lower extremity lymphedema: An umbrella systematic review supporting the American Venous Forum and the American Vein and Lymphatic Society clinical practice guidelines on management of lymphedema.
This umbrella systematic review evaluated the effectiveness of lymphovenous anastomosis (LVA) and vascularized lymph node transfer (VLNT) for lower extremity lymphedema (LEL) by analyzing 26 systematic reviews and 14…
Uterine Myxoid Inflammatory Myofibroblastic Sarcoma (MIMS) Harboring Pathogenic KRAS Mutations and Expressing ER, PR, and CD10.
A 40-year-old woman presented with a uterine tumor characterized by a whorled architecture and myxoid stroma. Immunohistochemical analysis revealed positivity for CD10, estrogen receptor (ER), and progesterone receptor…
Multimodal management of giant prolactinoma with extensive amyloid spherule deposition: a case report with review of the literature.
A 49-year-old man presented with headache and visual disturbances due to a giant prolactinoma, measuring 63 × 84 × 46 mm, with significant cavernous sinus invasion and marked hyperprolactinemia (30,969 ng/mL).
Primary SMARCB1-deficient intestinal carcinoma: Clinicopathological and molecular characterization of three cases with analysis of published data.
This report details three cases of primary SMARCB1-deficient intestinal carcinoma (SdIC), a rare and aggressive cancer type.
Title: Role of O6-methylguanine DNA methyltransferase status as predictive factor for alkylatin-based chemotherapy in advanced neuroendocrine tumors: State of the art.
This systematic review evaluated the predictive role of O6-Methylguanine DNA Methyltransferase (MGMT) status in advanced neuroendocrine tumors (NETs) treated with alkylating agents, including temozolomide (TMZ).
Long-term imaging characteristics of the pancreas related to diabetes induced by immune checkpoint inhibitor therapy.
A patient developed sudden hyperglycemia during pembrolizumab treatment for renal cell carcinoma, necessitating insulin therapy.
Image-guided interventional radiotherapy (modern brachytherapy) for treatment of vaginal intraepithelial neoplasia: single-institution experience and systematic literature review and meta-analysis.
This study evaluated the efficacy and safety of image-guided interventional radiotherapy (IG-IRT) for high-grade vaginal intraepithelial neoplasia (VaIN) through a retrospective case series of 10 patients and a…
Co-Occurrence of Achondroplasia and 16p11.2 Deletion Syndrome in a Child With Group 4 Medulloblastoma: Expanding the Spectrum of Dual Genetic Diagnoses.
A 13-year-old male with genetically confirmed achondroplasia (FGFR3 c.1138G > A) and a de novo 16p11.2 microdeletion developed metastatic Group 4 medulloblastoma at age 12, with leptomeningeal dissemination (M3).
Radiation Quality and Workflow in NRG GY017: Anti-PD-L1 (Atezolizumab) as an Immune Primer or Concurrently With Radiation Therapy for Node-Positive Locally Advanced Cervical Cancer.
This randomized controlled trial evaluated the quality of pretreatment radiation therapy (RT) plans in patients with node-positive locally advanced cervical cancer receiving atezolizumab.
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