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1998 articles

October 202624

Case ReportEndocrinology

Thyrotoxicosis-Associated Cholestatic Jaundice in a Patient With Incidental Gallstone Disease: A Case Report and Literature Review.

A 62-year-old woman presented with right upper quadrant pain, weight loss, and jaundice. Laboratory tests indicated cholestatic liver injury, and imaging revealed a solitary gallstone and signs of right-sided heart…

Am J Case RepOct 2, 2026Read case
Case ReportNeurosurgeryOpen access

Endoscopic third ventriculostomy for diencephalosynapsis-related hydrocephalus in MPDZ gene syndrome: a case report and review of the literature.

A female infant with prenatally diagnosed obstructive ventriculomegaly was confirmed to have MPDZ syndrome through whole-exome sequencing.

Childs Nerv SystOct 2, 2026Read case
Clinical ResearchNeurology

40 Hz transcutaneous auricular vagus nerve stimulation enhances verbal free recall in healthy adults by modulating frontal theta oscillations.

This randomized, single-blind, sham-controlled, three-arm trial examined whether 20 Hz or 40 Hz transcutaneous auricular vagus nerve stimulation (taVNS) affected verbal free recall and resting-state EEG theta activity…

NeuroimageOct 2, 2026Read summary
Clinical ResearchEndocrinologyOpen access

Effects of SGLT-2 Inhibitors on Plasma Concentrations and Renal Clearance of the Risk Marker Trimethylamine-N-Oxide in Patients With Type-2 Diabetes.

This randomized controlled trial investigated the effects of SGLT-2 inhibitors empagliflozin and dapagliflozin on plasma levels and renal clearance of trimethylamine-N-oxide (TMAO) in patients with Type 2 diabetes.

Endocrinol Diabetes MetabOct 2, 2026Read summary
Clinical ResearchCardiologyOpen access

Efficacy and Safety of Oral Non-Statin Lipid-Lowering Therapies in Dyslipidaemia: A Systematic Review and Network Meta-Analysis.

This systematic review and network meta-analysis evaluated the efficacy and safety of oral non-statin lipid-lowering therapies in adults with dyslipidaemia.

Endocrinol Diabetes MetabOct 2, 2026Read summary
Clinical ResearchGastroenterology

Genetic evidence for associations between gastroesophageal reflux disease and site-specific extraesophageal cancers: A Mendelian randomization study.

This Mendelian randomization study investigated the relationship between genetically predicted gastroesophageal reflux disease (GERD) and 22 extraesophageal cancers using data from over 600,000 individuals.

Medicine (Baltimore)Oct 2, 2026Read summary
Clinical ResearchNeurologyOpen access

Incidence, severity, and associated risk factors for amyloid-related imaging abnormalities in anti-amyloid monoclonal antibody therapy for early Alzheimer's disease: a systematic review and meta-analysis.

This systematic review and meta-analysis evaluated the incidence and risk factors for amyloid-related imaging abnormalities (ARIA) in 12,610 patients with early Alzheimer's disease receiving anti-amyloid monoclonal…

Neurol SciOct 2, 2026Read summary
Clinical ResearchAllergy & ImmunologyOpen access

Treatment of Multifood Allergy With Omalizumab or Multiallergen Oral Immunotherapy: A Randomized Clinical Trial.

This randomized clinical trial compared the efficacy of omalizumab versus multiallergen oral immunotherapy (MOIT) in treating multifood allergies in participants aged 1 to 55 years.

JAMA PediatrOct 1, 2026Read summary
Clinical ResearchPhysical Medicine & Rehabilitation

Platelet-rich plasma versus corticosteroid injections for facet and sacroiliac joint pain: a systematic review and meta-analysis with trial sequential analysis.

This systematic review and meta-analysis evaluated the efficacy of platelet-rich plasma (PRP) versus corticosteroid injections for treating facet and sacroiliac joint pain in 392 patients.

Pain MedOct 1, 2026Read summary
Clinical ResearchRadiology (Diagnostic)Open access

Volumetric Postcontrast T1 Turbo Spin-Echo vs Gradient-Recalled Echo MR Sequences for Detecting Brain Metastases: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis evaluated the diagnostic performance of postcontrast 3D T1 Turbo Spin-Echo (TSE) versus Gradient-Recalled Echo (GRE) MRI sequences for detecting brain metastases in 544 patients.

AJNR Am J NeuroradiolOct 1, 2026Read summary
Clinical ResearchEndocrinologyOpen access

Bone Accrual During Puberty Suppression and Gender-Affirming Therapy in Transgender Adolescents: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis evaluated bone mineral density (BMD) and z scores in transgender adolescents undergoing gonadotropin-releasing hormone agonist (GnRHa) therapy followed by gender-affirming…

JAMA PediatrOct 1, 2026Read summary
Clinical ResearchPulmonologyOpen access

Autonomous Oxygen Titration for Maintaining Normoxemia in Acutely Ill Adults: The SAVE-O2 AI Randomized Clinical Trial.

The SAVE-O2 AI randomized clinical trial evaluated the effectiveness of autonomous oxygen titration in maintaining normoxemia in acutely ill adults receiving supplemental oxygen.

JAMA Intern MedOct 1, 2026Read summary
Clinical ResearchPediatricsOpen access

Family-Centered Child Obesity Treatment: The TEAM UP Randomized Clinical Trial.

This pragmatic randomized clinical trial evaluated the effectiveness of enhanced standard of care with family-based behavioral treatment (ESOC+FBT) compared to enhanced standard of care alone (ESOC) in reducing percent…

JAMA PediatrOct 1, 2026Read summary
Clinical ResearchPediatricsOpen access

Factors affecting the experience of procedural and postoperative pain in children and adolescents - a systematic review.

This systematic review examined factors influencing procedural and postoperative pain in children and adolescents aged 3-18 years.

BMC Oral HealthOct 1, 2026Read summary
Clinical ResearchPediatricsOpen access

Erythropoietin for Neonatal Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial.

This multicenter randomized clinical trial evaluated the efficacy of erythropoietin (EPO) as an adjunct to therapeutic hypothermia in infants with moderate to severe hypoxic-ischemic encephalopathy (HIE).

JAMA PediatrOct 1, 2026Read summary
Clinical ResearchCardiologyOpen access

Diagnostic Accuracy of Circulating MicroRNAs for Coronary Artery Disease: An Updated Systematic Review and Meta-analysis.

This systematic review and meta-analysis evaluated the diagnostic accuracy of circulating microRNAs (miRNAs) for coronary artery disease (CAD) in 3,879 participants across 24 studies.

J Cardiovasc Transl ResOct 1, 2026Read summary
Clinical ResearchObstetrics & Gynecology

A double-blind multi-centre randomised placebo-controlled trial of doxycycline in women with recurrent miscarriage and chronic endometritis defined by CD138 positive stromal cells.

This multicenter, double-blind, randomized controlled trial evaluated the effect of preconceptual doxycycline on live birth rates in women with recurrent miscarriage and chronic endometritis defined by CD138 positive…

Hum ReprodOct 1, 2026Read summary
Clinical ResearchObstetrics & Gynecology

The impact of unilateral endometriomas on ovarian response to stimulation: a systematic review and meta-analysis.

This systematic review and meta-analysis examined the impact of unoperated unilateral endometriomas on ovarian response during stimulation cycles in women with endometriosis.

Hum ReprodOct 1, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Health Communication and Stepped Reminders Interventions for Lung Cancer Screening: A Randomized Clinical Trial.

This randomized clinical trial evaluated two patient-centered interventions aimed at increasing adherence to annual lung cancer screening among patients with normal findings.

JAMA Intern MedOct 1, 2026Read summary
Clinical ResearchHematology

Rilzabrutinib, an oral Bruton tyrosine kinase inhibitor, in patients with warm autoimmune haemolytic anaemia: a prospective, single-arm, multicentre, phase 2b safety and clinical activity study (LUMINA 2).

The LUMINA 2 study evaluated the safety and clinical activity of rilzabrutinib, a Bruton tyrosine kinase inhibitor, in adults with warm autoimmune haemolytic anaemia.

Lancet HaematolOct 1, 2026Read summary
Clinical ResearchEndocrinology

Effects of sprint interval training on markers of metabolic health: A three-level meta-analysis of randomised controlled trials.

This systematic review and three-level meta-analysis examined randomised controlled trials comparing sprint interval training (SIT) with no-exercise control or moderate-intensity continuous training (MICT) for metabolic…

J Sports SciOct 1, 2026Read summary
Clinical ResearchPreventive Medicine / Public Health

Positive emotions and credibility: Understanding how a community-engaged online campaign featuring clinician testimonials improved rural vaccine promotion.

This four-arm randomized survey experiment tested the community-engaged Communities Confronting COVID-19 campaign among 1,364 rural U.S. residents.

Soc Sci MedOct 1, 2026Read summary
Clinical ResearchGastroenterology

Balloon Enteroscopy-Assisted ERCP and EUS-Guided Biliary Drainage for Malignant Biliary Obstruction in Patients With Surgically Altered Anatomy: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis assessed balloon enteroscopy-assisted ERCP (BEA-ERCP) versus EUS-guided biliary drainage (EUS-BD) for malignant biliary obstruction in patients with surgically altered anatomy.

Dig EndoscOct 1, 2026Read summary
Case ReportPathology (Anatomic & Clinical)

Calcitonin-negative 'MTC-like' thyroid paraganglioma revealing an SDHD-related hereditary paraganglioma syndrome: functional confirmation of a non-canonical splice-site variant.

A 36-year-old woman presented with a 20-mm thyroid nodule classified as EU-TIRADS 4 and Bethesda III, with normal serum calcitonin levels.

Eur Thyroid JOct 1, 2026Read case

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