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1999 articles
October 202624
Systematic Review and Meta-Analysis on Rescue Stenting for Large Vessel Occlusion Due to Underlying Intracranial Atherosclerotic Stenosis.
This systematic review and meta-analysis evaluated the efficacy and safety of rescue stent placement in patients with large vessel occlusion (LVO) due to intracranial atherosclerotic stenosis (ICAS).
The Use of Deliberate Practice in Simulation-Based Surgical Training for Open General and Subspeciality Surgery: A Systematic Review.
This systematic review evaluates the integration of deliberate practice (DP) in simulation-based surgical training (SBST) for open general and subspecialty surgery.
"I Don't Speak English Well." Do Language Barriers Affect Automated External Defibrillator Use? A Randomized Simulation Study With Spanish-Speaking Laypeople.
This randomized controlled trial assessed the impact of language barriers on automated external defibrillator (AED) use among 50 Spanish-speaking university students.
Cost-Effectiveness of Adjunctive Middle Meningeal Artery Embolization for Chronic Subdural Hematoma: Secondary Analysis of EMBOLISE.
This secondary analysis of the EMBOLISE randomized trial evaluated the cost-effectiveness of adjunctive middle meningeal artery embolization (MMAE) versus evacuation surgery (ES) alone in 42 patients with chronic…
Fibrin-Heparin-Coated Intracranial Stents as Salvage Therapy in Pediatric Focal Cerebral Arteriopathy-Inflammatory Type.
A 13-year-old boy presented with progressive arterial ischemic stroke due to focal cerebral arteriopathy inflammatory type.
[18F]RCCB6 PET/CT in Diagnosing Clear-Cell Renal Cell Carcinomas: A Prospective Comparison Study with [18F]FDG PET/CT and Conventional Imaging.
[18F]RCCB6 PET/CT was evaluated in a single-center phase II trial for detecting metastases in clear-cell renal cell carcinoma (ccRCC).
Clinical trial: The Effect on Intragastric pH and Pharmacokinetics of the PCAB Linaprazan Glurate in Healthy Subjects After Repeat-Dose Administration for up to 14 Days.
This open, randomised, parallel-group Phase 1 trial assessed intragastric pH and pharmacokinetics after single and repeated linaprazan glurate (LG) dosing in 73 healthy subjects.
Temporal Net Water Uptake Evolution and Its Association with Functional Outcome in Acute Ischemic Stroke.
This multicenter randomized controlled trial examined the relationship between temporal changes in net water uptake (NWU) and functional outcomes in 115 patients with acute ischemic stroke.
Ziftomenib with venetoclax and azacitidine for relapsed/refractory NPM1-mutated acute myeloid leukemia.
The KOMET-007 phase 1 trial evaluated the combination of ziftomenib with venetoclax and azacitidine in adults with relapsed/refractory NPM1-mutated acute myeloid leukemia (AML).
Follow-Up 18F-Fluorodeoxyglucose Positron Emission Tomography in Treated Patients With Giant Cell Arteritis: A Systematic Review and Metaanalysis.
This systematic review and meta-analysis evaluated the use of 18F-fluorodeoxyglucose (FDG) PET to monitor disease activity in patients with large-vessel giant cell arteritis (LV-GCA) who showed clinical improvement…
Bimekizumab Long-Term Safety and Efficacy Across the Spectrum of Axial Spondyloarthritis Over 3 Years: Results From 2 Phase III Studies.
This study evaluated the long-term safety and efficacy of bimekizumab, an IL-17A and IL-17F inhibitor, in patients with axial spondyloarthritis over 3 years.
Pediatric Brain Tumor Consortium Phase I Study of CD40 Agonist Sotigalimab in Pediatric and Young Adult Patients with Recurrent CNS Tumors and Newly Diagnosed DIPG.
The PBTC-051 study evaluated the safety and preliminary efficacy of the CD40 agonist sotigalimab in 31 pediatric and young adult patients with recurrent CNS tumors and newly diagnosed DIPG.
Systematic Review: Inclusion of Patients With Difficult-to-Treat Inflammatory Bowel Disease in Randomized Controlled Trials of Advanced Therapies.
This systematic review examined how patients with difficult-to-treat inflammatory bowel disease (DTT-IBD) were represented in randomized controlled trials of advanced therapies for ulcerative colitis and Crohn’s…
Davos@home: Integrating objective home monitoring into eHealth self-management support after alpine altitude climate treatment for severe asthma.
This 12-month pragmatic randomised trial assessed whether objective home monitoring adds benefit to eHealth self-management after Alpine Altitude Climate Treatment (AACT) in adults with severe asthma.
The Duke CSF-Venous Fistula Confidence Score: Real-World Application on CT Myelography.
A case of a patient with spontaneous intracranial hypotension was evaluated using CT myelography to identify a suspected CSF-venous fistula (CVF).
Avutometinib, Abemaciclib, and Fulvestrant in Patients with HR+/HER2- Metastatic Breast Cancer Previously Treated with CDK4/6 Inhibitor: A Single-Arm Phase I Trial.
This single-arm phase I trial evaluated the combination of avutometinib, abemaciclib, and fulvestrant in 16 patients with HR+/HER2- metastatic breast cancer who had previously progressed on CDK4/6 inhibitors.
Osimertinib plus Gefitinib in Patients with EGFR-Mutated Advanced Non-Small Cell Lung Cancer and EGFR (C797X) Mutation Following First-Line Osimertinib: ORCHARD.
The ORCHARD study was a phase II trial assessing the efficacy of osimertinib plus gefitinib in patients with EGFR-mutated advanced non-small cell lung cancer (NSCLC) and EGFR C797X mutation after progression on…
A Randomized, Nivolumab-Controlled, Phase II Biomarker Study of Lomvastomig and Tobemstomig in Advanced or Metastatic Squamous Cell Carcinoma of the Esophagus.
This phase II randomized controlled trial evaluated the efficacy of bispecific antibodies lomvastomig and tobemstomig against nivolumab in 190 checkpoint inhibitor-naïve patients with advanced esophageal squamous cell…
Exceptional and Durable Response to Selpercatinib in a Patient with Apparently RET -Negative, HRAS -, and NF1 -Mutated Metastatic Medullary Thyroid Carcinoma.
A 50-year-old woman presented with rapidly progressive medullary thyroid carcinoma (Ki-67 30%) and extensive liver and bone metastases.
Modified One Anastomosis Gastric Bypass (OAGB) Versus Duodenojejunostomy for Treatment of Superior Mesenteric Artery Syndrome: A Randomized Controlled Trial.
This randomized controlled trial compared modified one anastomosis gastric bypass (OAGB) to duodenojejunostomy in 20 patients with superior mesenteric artery syndrome.
Intrathecal Allogeneic B7-H3-Targeted CAR γδ T Cells for Leptomeningeal Metastasis from Solid Tumors: Safety, Efficacy, and Immunologic Dynamics in a Phase I Trial.
This phase I trial evaluated the safety and efficacy of intrathecal QH104, an allogeneic B7-H3-targeted CAR γδ T-cell therapy, in 3 patients with leptomeningeal metastasis from solid tumors.
Perioperative Safety and Effectiveness of Laparoscopic Heller Myotomy in Elderly Patients: Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the perioperative safety and effectiveness of laparoscopic Heller myotomy (LHM) in patients aged 65 years or older.
Molecular Profiling of Tisotumab Vedotin-Treated Patients Identifies Immune Pathways Associated with Clinical Activity.
This phase II multicenter trial evaluated the efficacy of tisotumab vedotin (TV) in patients with recurrent or metastatic cervical cancer (r/mCC).
Nonarmored GCC-Targeting CAR T-cell Therapy Demonstrates Significant Efficacy in Patients with Advanced Colorectal Cancer.
This phase I clinical trial evaluated the safety and preliminary efficacy of nonarmored GCC-targeted CAR T-cell therapy in 24 heavily pretreated metastatic colorectal cancer patients.
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