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2000 articles
October 202624
MK-4002, a B-cell maturation antigen-targeting T-cell engager, in relapsed or refractory multiple myeloma: a first-in-human, open-label, phase 1 study.
This first-in-human, open-label, multicentre phase 1 study evaluated the safety, pharmacokinetics, and preliminary activity of the BCMA-targeting T-cell engager MK-4002 in adults with heavily pretreated relapsed or…
Same-day diagnosis and robotic resection of rare primary pulmonary melanoma: a robotic bronchoscopy-guided approach.
A man in his 70s presented with a lingular pulmonary nodule suspicious for non-small cell lung cancer. He underwent robotic navigation bronchoscopy for biopsy, which was followed by robotic-assisted thoracic surgery.
Safe electrophysiology-guided resection of an epileptogenic non-exophytic hamartoma at the floor of the fourth ventricle in a child.
Hamartoma of the floor of fourth ventricle (HFFV) is an extremely rare entity known to be causing focal movement disorders in children.
Associations between duration of status epilepticus and clinical outcomes in adults: a systematic review.
This systematic review examined the relationship between the duration of status epilepticus (SE) and clinical outcomes in adults, analyzing 43 studies.
Parenchymal Injury Caused by Complete Migration of a Bone of Japanese Horse Mackerel Within the Pancreatic Uncinate Process Through a Duodenal Diverticulum, Resulting in Sepsis and Multiple Pyogenic Liver Abscesses.
A 79-year-old man developed abdominal pain and fever three days after ingesting grilled Japanese horse mackerel. Imaging revealed a fish bone fully migrated into the pancreatic uncus through a duodenal diverticulum…
Genome-wide meta-analysis dissects the genetic basis and health implications of circulating taurine.
This genome-wide meta-analysis examined the genetic basis of circulating taurine levels in 36,490 European individuals. The study identified six common and two rare genetic loci associated with taurine levels and…
Early structured rehabilitation following open retromuscular incisional hernia repair: a prospective randomized controlled trial.
This randomized controlled trial evaluated the impact of structured early rehabilitation on functional recovery after open retromuscular incisional hernia repair in 30 adults.
TRICALS risk score augments but cannot replace neurofilament as a prognostic biomarker in ALS.
This randomized controlled trial evaluated the TRICALS risk score as a prognostic tool in amyotrophic lateral sclerosis (ALS) using data from the MIROCALS trial (n = 220).
GLP-1 receptor agonists for obstructive sleep apnea: a meta-analysis of randomized controlled trials.
This meta-analysis of randomized controlled trials evaluated the efficacy and safety of GLP-1 receptor agonists in adults with moderate-to-severe obstructive sleep apnea (OSA).
Early-onset VEXAS syndrome mimicking orbital cellulitis and successfully treated with allogeneic hematopoietic stem cell transplantation.
A 25-year-old male presented with recurrent fever, weight loss, arthralgia, and symptoms resembling orbital cellulitis. Imaging revealed orbital soft tissue inflammation, while laboratory tests showed macrocytic anemia…
Outcomes after middle meningeal artery embolization using coils alone for chronic subdural hematoma: A systematic review and single-arm meta-analysis.
This systematic review and single-arm meta-analysis evaluated the outcomes of coil-only middle meningeal artery embolization (MMAE) for chronic subdural hematoma (cSDH) in 397 patients across 10 studies.
Ventriculo-arterial coupling in acute heart failure: prognostic and therapeutic insights - a systematic review and meta-analysis of multivariable-adjusted data.
This systematic review and meta-analysis evaluated the prognostic significance of non-invasive ventricular-arterial coupling (VAC) in 36,989 patients hospitalized with acute heart failure (AHF).
Cardiovascular safety in middle-aged and older men under testosterone replacement therapy: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the cardiovascular safety of testosterone replacement therapy (TRT) in middle-aged and older men, analyzing data from 31 randomized-controlled trials involving 9,437…
Efficacy and safety of MEK inhibitors for NF1-associated symptomatic, inoperable plexiform neurofibromas: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the efficacy and safety of MEK inhibitors for treating symptomatic, inoperable plexiform neurofibromas in patients with neurofibromatosis type 1 (NF1).
Australian Digital Mental Health Services for Anxiety and Depression: Meta-Analysis and Comparison Study.
This meta-analysis evaluated the effectiveness and uptake of three Australian digital mental health services (DMHSs) for anxiety and depression. Over 282,000 consumers accessed these services from 2013 to 2021.
Reliability of Childhood Autism Rating Scale, Second Edition, Assessments Using Telepsychiatry for Children With Neurodevelopmental Disorders and Their Caregivers: Randomized Feasibility Study.
This randomized feasibility study evaluated the interrater reliability of the Childhood Autism Rating Scale, Second Edition (CARS2) between telepsychiatry and face-to-face assessments in 73 children aged 6 to 17 with…
A High-Energy Military Femoral Fracture With Multidrug-Resistant Infection: A Case Report.
A 37-year-old military man presented with a high-energy femoral fracture complicated by a multidrug-resistant infection. After multiple debridement procedures and the use of an external fixation device, he underwent…
Effectiveness of Chatbots in Mental Health Screening and Assessment: Systematic Review.
This systematic review evaluated the effectiveness of chatbots and AI-based conversational agents for mental health screening and assessment in adults.
A Systematic Review of Stem Cell Secretome-Derived Exosomes for Neuropathic Pain: Therapeutic Mechanisms and Translational Potential.
This systematic review assessed the therapeutic mechanisms and potential of stem cell secretome-derived exosomes for neuropathic pain (NP) in preclinical and clinical studies.
Comparative efficacy and safety of orally administered PCSK9 inhibitors in patients with Hypercholesterolaemia: a dose-stratified systematic review and network meta-analysis.
This network meta-analysis evaluated the efficacy and safety of orally administered PCSK9 inhibitors in patients with hypercholesterolemia, analyzing five randomized trials with 4,227 participants.
5-year survival rate and determinants of decreased survival among patients with breast cancer in Africa: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the 5-year survival rate of breast cancer patients in Africa, analyzing 55 studies with 19,577 participants. The pooled 5-year survival rate was found to be 40.38%.
Immersive 3D vs Physical Simulation in Training Novices for Laser-Based Endourological Procedures: Protocol for a Randomized Controlled Trial.
This randomized controlled trial aims to compare immersive 3D simulation and physical simulation training for novice medical students in endourological laser-based procedures.
Digital Twin-Assisted Risk Disclosure in Adults Undergoing Elective Bronchoscopy: Multicenter Randomized Controlled Trial.
This multicenter randomized controlled trial evaluated the impact of digital twin-assisted risk disclosure on prebronchoscopy anxiety and postbronchoscopy satisfaction in adults undergoing elective bronchoscopy.
Duplicated spermatic cord encountered during inguinal hernia repair.
A male patient in his seventies presented for elective open right inguinal hernia repair. During the procedure, complete duplication of the spermatic cord was identified, with two distinct structures each containing a…
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