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1566 articles
October 202624
Bimekizumab Long-Term Safety and Efficacy Across the Spectrum of Axial Spondyloarthritis Over 3 Years: Results From 2 Phase III Studies.
This study evaluated the long-term safety and efficacy of bimekizumab, an IL-17A and IL-17F inhibitor, in patients with axial spondyloarthritis over 3 years.
Ziftomenib with venetoclax and azacitidine for relapsed/refractory NPM1-mutated acute myeloid leukemia.
The KOMET-007 phase 1 trial evaluated the combination of ziftomenib with venetoclax and azacitidine in adults with relapsed/refractory NPM1-mutated acute myeloid leukemia (AML).
Intrathecal Allogeneic B7-H3-Targeted CAR γδ T Cells for Leptomeningeal Metastasis from Solid Tumors: Safety, Efficacy, and Immunologic Dynamics in a Phase I Trial.
This phase I trial evaluated the safety and efficacy of intrathecal QH104, an allogeneic B7-H3-targeted CAR γδ T-cell therapy, in 3 patients with leptomeningeal metastasis from solid tumors.
Follow-Up 18F-Fluorodeoxyglucose Positron Emission Tomography in Treated Patients With Giant Cell Arteritis: A Systematic Review and Metaanalysis.
This systematic review and meta-analysis evaluated the use of 18F-fluorodeoxyglucose (FDG) PET to monitor disease activity in patients with large-vessel giant cell arteritis (LV-GCA) who showed clinical improvement…
[18F]RCCB6 PET/CT in Diagnosing Clear-Cell Renal Cell Carcinomas: A Prospective Comparison Study with [18F]FDG PET/CT and Conventional Imaging.
[18F]RCCB6 PET/CT was evaluated in a single-center phase II trial for detecting metastases in clear-cell renal cell carcinoma (ccRCC).
Primary care practitioners' experiences managing urinary tract infections: a qualitative evidence synthesis.
This qualitative evidence synthesis explored the experiences of primary care practitioners (PCPs) managing urinary tract infections (UTIs) across various international settings.
Management of Antineutrophil Cytoplasmic Antibody-Associated Alveolar Hemorrhage: A Bayesian Reanalysis of the PEXIVAS Trial.
This Bayesian reanalysis of the PEXIVAS trial focused on adults with antineutrophil cytoplasmic antibody-associated vasculitis and diffuse alveolar hemorrhage (DAH).
Temporal Net Water Uptake Evolution and Its Association with Functional Outcome in Acute Ischemic Stroke.
This multicenter randomized controlled trial examined the relationship between temporal changes in net water uptake (NWU) and functional outcomes in 115 patients with acute ischemic stroke.
Cost-Effectiveness of Adjunctive Middle Meningeal Artery Embolization for Chronic Subdural Hematoma: Secondary Analysis of EMBOLISE.
This secondary analysis of the EMBOLISE randomized trial evaluated the cost-effectiveness of adjunctive middle meningeal artery embolization (MMAE) versus evacuation surgery (ES) alone in 42 patients with chronic…
Fibrin-Heparin-Coated Intracranial Stents as Salvage Therapy in Pediatric Focal Cerebral Arteriopathy-Inflammatory Type.
A 13-year-old boy presented with progressive arterial ischemic stroke due to focal cerebral arteriopathy inflammatory type.
Systematic Review and Meta-Analysis on Rescue Stenting for Large Vessel Occlusion Due to Underlying Intracranial Atherosclerotic Stenosis.
This systematic review and meta-analysis evaluated the efficacy and safety of rescue stent placement in patients with large vessel occlusion (LVO) due to intracranial atherosclerotic stenosis (ICAS).
Volumetric Postcontrast T1 Turbo Spin-Echo vs Gradient-Recalled Echo MR Sequences for Detecting Brain Metastases: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the diagnostic performance of postcontrast 3D T1 Turbo Spin-Echo (TSE) versus Gradient-Recalled Echo (GRE) MRI sequences for detecting brain metastases in 544 patients.
Evaluating CPR Breast Attachment Impact on EMT Training: A Randomized Controlled Trial.
This randomized controlled trial evaluated the impact of the ReviveHer breast attachment on EMT students' willingness and comfort in performing CPR on breasted and nonbreasted individuals.
The Use of Deliberate Practice in Simulation-Based Surgical Training for Open General and Subspeciality Surgery: A Systematic Review.
This systematic review evaluates the integration of deliberate practice (DP) in simulation-based surgical training (SBST) for open general and subspecialty surgery.
"I Don't Speak English Well." Do Language Barriers Affect Automated External Defibrillator Use? A Randomized Simulation Study With Spanish-Speaking Laypeople.
This randomized controlled trial assessed the impact of language barriers on automated external defibrillator (AED) use among 50 Spanish-speaking university students.
HIV-associated pulmonary arterial hypertension: improving survival despite persistent treatment gaps - a systematic review and meta-analysis.
This systematic review and meta-analysis examined 12 cohorts of patients with HIV-associated pulmonary arterial hypertension (HIV-PAH), totaling 537 individuals.
INDIVIDUAL ARTICLE: Tildrakizumab for Real-World Psoriasis Care: Clinical Lessons From Medically Complex and Underserved Patient Populations.
This case review discusses 16 patients with moderate-to-severe plaque psoriasis treated with tildrakizumab, a monoclonal antibody targeting interleukin-23.
Cicatricial Ectropion in the Setting of IL-13 Inhibition.
An 81-year-old man with extensive atopic dermatitis was treated with dupilumab, leading to significant improvement. However, he later developed ocular symptoms and inferior cicatricial ectropion of the left lower eyelid.
Contact Allergens Associated With Nummular Eczema: A Systematic Review.
This systematic review examined the association between contact allergens and nummular eczema (NE) by analyzing 10 observational studies.
Pulsed Dye Laser for Sensory Dysesthesias Associated With Chronic Radiation Dermatitis.
Two breast cancer patients with chronic radiation dermatitis (CRD) presented with debilitating sensory dysesthesias unresponsive to conventional treatments.
Biologics and Small-Molecule Inhibitors for the Treatment of Nummular Eczema: A Systematic Review.
This systematic review evaluated the efficacy of biologics and small-molecule inhibitors for treating nummular eczema (NE) by analyzing 10 studies.
Age at Iatrogenic Menopause and Cardiovascular Morbidity and Mortality: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the cardiovascular morbidity and mortality associated with iatrogenic menopause in 2,617,942 women.
Bilateral Costoclavicular Brachial Plexus Block for Closed Reduction of Bilateral Elbow Dislocation: A Case Report and Review of the Literature.
A 60-year-old man presented with bilateral posterolateral elbow dislocation following a road traffic accident. He underwent closed reduction and cast application under a bilateral ultrasound-guided costoclavicular…
Perioperative Management of an Implanted Spinal Cord Stimulator: A Problem-Based Learning Discussion.
A patient with an implanted spinal cord stimulator (SCS) was scheduled for elective surgery. The case highlighted critical aspects of perioperative management, including the identification of the device, potential…
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