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433 articles
May 202619
Diffuse Large B-Cell Lymphoma Presenting as a Thigh Mass: A Case Report.
A 76-year-old female presented with swelling and pain in her right thigh. Imaging revealed a soft-tissue mass that raised concerns for sarcoma.
Pegcetacoplan Delivers Real-World Therapeutic Benefits and Reduces Disease Burden for Patients With Paroxysmal Nocturnal Haemoglobinuria: A Systematic Literature Review of Pegcetacoplan Real-World Clinical and Patient-Reported Outcomes.
This systematic literature review evaluated real-world evidence for pegcetacoplan in adults with paroxysmal nocturnal haemoglobinuria (PNH).
Rare and complex three-way t(8;11;21) translocation in core-binding factor acute myeloid leukemia transforming into refractory mediastinal myeloid sarcoma: cytogenetic and molecular insights.
A young patient with core-binding factor acute myeloid leukemia (CBF-AML) and the RUNX1::RUNX1T1 fusion gene presented with a rare three-way t(8;11;21) translocation, alongside mutations in KIT, ASXL1, and TET2.
A case of congenital thrombotic thrombocytopenic purpura presenting with renal dysfunction in adulthood caused by a novel compound heterozygous ADAMTS13 mutation.
A 36-year-old male presented with acute thrombocytopenia and a 5-year history of chronic thrombocytopenia, alongside 3 months of renal dysfunction.
Thrombotic microangiopathy-like acute kidney injury revealing a germline GATA1 mutation in a child with inherited cytopenia.
An 8-year-old boy with a history of steroid-dependent cytopenias and congenital anomalies presented with severe infection, hemolysis, thrombocytopenia, and acute kidney injury requiring hemodialysis.
Oral manifestation and gingival biopsy contributing to the early diagnosis of Langerhans cell histiocytosis in a paediatric patient.
A 3-year-old child presented with bilateral osteolytic lesions, significant bone loss, and multiple ulcerative gingival lesions. Accompanying symptoms included lymphadenopathy and cranial pain.
Atypical short tandem repeat allelic patterns in a sexual assault case involving hematopoietic stem cell transplantation.
A female victim of sexual assault underwent forensic examination, revealing conflicting short tandem repeat (STR) profiles in various biological samples.
RCLARITY: A Prospective Phase II Study of Rituximab Combined With Lenalidomide and Chidamide (RLC) for the Treatment of Relapsed/Refractory Angioimmunoblastic T-Cell Lymphoma.
The RCLARITY trial, a prospective Phase II study, evaluated the efficacy and safety of a chemotherapy-free regimen combining rituximab, lenalidomide, and chidamide in 28 adults with relapsed/refractory…
Secondary leukaemia after testicular germ cell tumour treatment: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the incidence of secondary leukaemia in 57,365 patients treated for testicular germ cell tumours (TGCTs).
Life-threatening hemorrhage from acquired factor V deficiency with non-inhibitory, hyperclearance-type antibodies successfully treated with rituximab then belimumab.
A 66-year-old woman with Sjögren’s disease and no previous bleeding tendency presented with rapidly worsening low back pain and severe coagulopathy.
Primary Oral MALT Lymphoma Without Nodal or Systemic Involvement: A Rare Presentation.
A middle-aged patient presented with a slow-growing, asymptomatic oral lesion that was initially misidentified as an oral lipoma.
Performance of Automated Hematology Analyzer Criteria in Detecting Peripheral Blood Smear Abnormalities: A Systematic Literature Review.
This systematic review analyzed 68 studies over 20 years to evaluate the performance of automated hematology analyzers in detecting peripheral blood smear (PBS) abnormalities.
Dual pathogenic variants in ADAMTS13 and CFHR1/CFHR3 deletion: divergent thrombotic microangiopathy phenotypes in siblings.
Two male siblings presented with hereditary anemia and thrombocytopenia, along with unexplained hepatosplenomegaly. The elder sibling developed acute thrombotic microangiopathy (TMA) with severe complications, while the…
Cutaneous Involvement by Blastoid Mantle Cell Lymphoma Presenting as Cervical Abscess: A Rare Extranodal Diagnostic Challenge.
A 73-year-old male presented with a solitary fluctuant swelling in the left cervical region, initially suspected to be an abscess. Imaging showed a localized lesion without lymphadenopathy.
A systematic review of short-term outcomes in patients with anti-factor H associated atypical HUS managed with plasma exchanges versus eculizumab.
This systematic review compared short-term outcomes in patients with anti-factor H antibody-associated atypical haemolytic uraemic syndrome affecting native kidneys, treated with plasma exchange (PEX) or eculizumab…
Buprenorphine Initiation Regimen for Pain in Two Pregnant Patients with Sickle Cell Disease.
Two pregnant patients with sickle cell disease (SCD) experiencing chronic pain were transitioned to buprenorphine for pain management.
Zinc-Induced Hematologic Toxicities: A Systematic Review of Descriptive Studies.
This systematic review analyzed 34 studies detailing zinc-induced hematologic toxicities in humans, highlighting that excessive zinc exposure can lead to anemia, neutropenia, and leukopenia.
The Homozygous p.(Arg215Ter) Variant in XRCC2 Is Associated With Atypical Fanconi Anemia Without Major Hematological Abnormalities in Childhood.
Two young adults from consanguineous parents presented with a homozygous p.(Arg215Ter) variant in XRCC2, exhibiting features of Fanconi Anemia (FA) such as mild intellectual disability, microcephaly, distinctive facial…
68 Ga-Pentixafor PET/CT Outperforms 18 F-FDG PET/CT in a Patient With Adult T-cell Leukemia/Lymphoma.
A patient with adult T-cell leukemia/lymphoma presented with extranodal hepatic lesions and multiple nodal lesions. Imaging studies using both 18 F-FDG and 68 Ga-pentixafor PET/CT were conducted.
April 20265
Extracorporeal membrane oxygenation as a pre-transplant rescue therapy in a patient with an oncohematological condition.
A 2-year-old boy with severe bone marrow aplasia and septic shock was treated with extracorporeal membrane oxygenation (ECMO) as a bridge to hematopoietic stem cell transplantation.
A randomized, multicenter phase II trial to compare prophylaxis of graft versus host disease with tacrolimus and mycophenolate mofetil versus ruxolitinib after post-transplant cyclophosphamide.
This multicenter phase II randomized trial evaluated the efficacy and safety of PTCy-Ruxo versus PTCy-Tac-MMF for GVHD prophylaxis in 128 adults with acute myeloid or lymphoblastic leukemia post-HCT.
A systematic review with meta-analysis on racial and ethnic disparities in acute venous thromboembolism diagnosis and management.
This systematic review and meta-analysis examined racial and ethnic disparities in the diagnosis and management of acute venous thromboembolism (VTE) among U.S. adults.
Classification of Plasmodium vivax as artefactual cells by the CellaVision DM9600: a system limitation in a non-endemic area.
A 46-year-old Taiwanese man returning from Indonesia presented with fever and thrombocytopenia. An automated cellular morphology analyzer misidentified Plasmodium vivax as artefactual cells, delaying diagnosis.
First report of a rare hemoglobin variant in the Chinese population: clinical and hematological characteristics of Hb Norton [HBA2:c.217C>G] and its impact on HbA1c testing: a case report.
A 38-year-old man presented with a normal clinical and hematological profile but had an unexpectedly high HbA1c level of 20.24% using HPLC.
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