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441 articles
April 202624
Coadministration of mRNA-1345 RSV vaccine with high-dose quadrivalent influenza vaccine in adults aged 65 and older: An observer-blinded, placebo-controlled, randomized, phase 3 trial.
This phase 3 randomized trial assessed the safety and immunogenicity of the mRNA-1345 RSV vaccine coadministered with high-dose quadrivalent influenza vaccine in adults aged 65 and older (n=1900).
Validity and reliability of an automated fall risk assessment system using a depth camera in community-dwelling adults: A proof-of-concept pilot study.
This proof-of-concept pilot study evaluated the validity and reliability of a consumer-grade depth camera system for automated fall risk assessment in 39 community-dwelling adults.
Toward Precision Psychiatry: Using Clinical and Pharmacokinetic Data to Increase Antidepressant Dose or Change Treatment in Late-Life Depression.
This randomized controlled trial investigated the use of clinical, pharmacogenetic, and pharmacokinetic data to guide treatment decisions in older patients with major depressive disorder (MDD) who did not fully respond…
Promoting digital memory aid use in older adults with cognitive concerns: A pilot randomized controlled trial of adaptive web-based training.
This pilot randomized controlled trial evaluated a web-based training platform for older adults with cognitive concerns, comparing self-guided support to clinician-supported sessions.
Brief intervention for inappropriate z-hypnotics use in older adults: a before and after intervention study in primary care.
This randomized controlled trial evaluated the long-term effects of a brief intervention for inappropriate z-hypnotic use in older adults within primary care.
Efficacy of adjunctive intermittent theta-burst stimulation on depressive and insomnia symptoms in elderly patients with depression and comorbid insomnia: A randomized, sham-controlled trial.
This randomized, sham-controlled trial investigated the effects of intermittent theta-burst stimulation (iTBS) on depressive and insomnia symptoms in 36 elderly patients with late-life depression and comorbid insomnia.
Medical students' attitudes towards older persons - a systematic review and meta-analysis.
This systematic review and meta-analysis examined medical students' attitudes towards older persons, analyzing 21 studies with a total of 3940 participants.
Care navigation for older adults after stroke - A systematic review and meta-analyses to guide social prescribing.
This systematic review and meta-analysis evaluated the impact of care navigation on anxiety, depression, quality of life, and well-being in older adults (60+) post-stroke.
Effectiveness of functional tasks exercise on functional ability and health-related quality of life in community-dwelling older adults: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effectiveness of Functional Task Exercise (FTE) on functional ability and health-related quality of life (HRQoL) in community-dwelling older adults.
Influence of Baseline Smoking Status on Intensive Blood Pressure Control: Results From the STEP Randomized Trial.
This secondary analysis of the STEP randomized trial evaluated the impact of baseline smoking status on cardiovascular outcomes in 8489 elderly hypertensive patients.
Effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) on depression and anxiety in older adults: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) on depressive symptoms in older adults (≥60 years).
Kidney transplant outcomes in patients aged ≥ 70 years: a systematic review and meta-analysis of multicenter or registry-based studies with future directions and a multicenter study proposal.
This systematic review and meta-analysis examined kidney transplant outcomes in recipients aged ≥ 70 years, analyzing data from five multicenter studies with 272,982 participants.
Biobehavioral and Interpersonal Predictors of Cognitive Impairment in Older Adults With Type 2 Diabetes: A Systematic Review of Cohort Studies.
This systematic review analyzed cohort studies to identify predictors of cognitive impairment in older adults with type 2 diabetes.
Predictors of Cognitive Behavioral Therapy for Insomnia in Older Adults.
This randomized controlled trial investigated predictors of success in Cognitive Behavioral Therapy for Insomnia (CBT-I) among 96 older adults with insomnia.
Updating knowledge on existing approaches on advanced care planning interventions: An umbrella review.
This umbrella review synthesizes findings from 61 systematic reviews on advanced care planning (ACP) interventions, focusing on older adults.
Diagnosis of Q-fever pneumonia by tNGS of bronchoalveolar lavage fluid in an elderly patient.
This study explores the value of targeted next-generation sequencing (tNGS) in the etiological diagnosis of unexplained pneumonia in elderly patients.
Dysphagia in behavioural variant of frontotemporal dementia- a systematic review.
This systematic review examined how dysphagia is identified and described in people with behavioural variant frontotemporal dementia (bvFTD).
Fall Injury Avoidance Strategy Scale (FIAS)-Validation of a Scale to Quantify Fall-Related Protective Movements.
This validation study assessed the video-based Fall Injury Avoidance Strategy Scale (FIAS) in 23 older adults at risk of injurious falls, using 376 standardized experimental falls recorded at baseline, after…
Effect of intraoperative 40-hz gamma-frequency auditory stimulation on postoperative delirium in older adults undergoing major surgery: a randomized clinical trial protocol.
This prospective, parallel-group randomized controlled trial protocol will evaluate intraoperative 40-Hz gamma-frequency auditory stimulation in 550 older adults undergoing major noncardiac, nonneurosurgical surgery…
Psychometric Performance of Preference-Weighted Instruments in Older Adults: A Systematic Review.
This systematic review assessed the psychometric properties of preference-weighted health-related quality-of-life instruments in adults aged ≥60. It included 106 studies evaluating 14 measures.
Urinary Incontinence and Risk of All-Cause Mortality: A Systematic Review and Meta-Analysis of Observational Studies.
This systematic review and meta-analysis pooled observational cohort studies comparing all-cause mortality in adults with and without urinary incontinence (UI).
Hypnotic-Induced Fall Risk Upon Awakening: A Network Meta-Analysis of Postural Stability Outcomes.
This systematic review and frequentist random-effects network meta-analysis compared morning postural stability after hypnotic use, using randomized controlled trials that assessed static body sway or dynamic walking…
EffectS of Lifestyle Interventions in Older PEople With Obesity (Effective SLOPE): a Systematic Review With Network Meta-Analyses.
This systematic review and network meta-analysis assessed lifestyle interventions for community-dwelling older adults with obesity, drawing on randomized controlled trials lasting at least 12 weeks.
An Enhanced Treatment Algorithm Targeting Mucosal Healing Is Effective and Safe in Older Patients With Crohn's Disease: A Post Hoc Analysis of the REACT2 Trial.
This post hoc analysis of the randomized REACT2 trial examined whether age modified the effect of enhanced-care versus step-care algorithms in patients with Crohn’s disease.
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