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785 articles
July 202618
Brain Neuromodulation via Endoscopic Gastric Implant Improves Glycemic Control in Insulin-Dependent Type-2 Diabetes: First-in-Human Feasibility and Autonomic Response Study.
A 69-year-old male with a 25-year history of insulin-dependent type-2 diabetes underwent implantation of a Brain NeuroModulator (BNM) device in the gastric submucosa.
Gut Microbiome-Modulating therapeutics and lipid profile in metabolic syndrome: A systematic review and meta-analysis of clinical trials.
This systematic review and meta-analysis evaluated the impact of gut microbiome-modulating interventions on lipid profiles in adults with metabolic syndrome.
Campylobacter beyond the gut: A case series of Campylobacter jejuni bacteraemia with atypical presentations.
A case of Campylobacter jejuni bacteraemia was presented, which is an uncommon manifestation of this pathogen typically associated with gastroenteritis.
Endometriosis in the cecum diagnosed via forward-viewing endoscopic ultrasound-guided tissue acquisition with a 19G fine-needle biopsy needle: a case report.
A 30-year-old woman was referred after colonoscopy identified a protruding cecal lesion. Contrast-enhanced CT showed a 37-mm enhancing mass and an adjacent lesion considered a possible enlarged lymph node, raising…
The Dynamics of Pharyngeal Shortening in Healthy Swallowing: Effects of Sex, Age, Bolus Volume and Consistency.
This multicenter clinical study characterised pharyngeal shortening during swallowing in 80 healthy adults, balanced by sex and spanning four age groups.
Hypertriglyceridemic pancreatitis subphenotypes and differential responses to low-molecular-weight heparin: analyses from a cohort and a randomized controlled trial.
This study identified two distinct subphenotypes of hypertriglyceridemic pancreatitis (HTG-AP) in a cohort of 1483 patients and validated these findings in a randomized controlled trial with 533 participants.
Utilization of Cancer Navigators in the Management of Gastric Cancer: A Systematic Review.
This systematic review evaluated the role of cancer navigation programs in managing gastric cancer, analyzing seven studies with 3465 patients.
M2 macrophage activation in recurrent acute pancreatitis: an explorative analysis of a randomized controlled trial.
This exploratory analysis of a multicenter, randomized controlled trial evaluated M2 macrophage activation in 56 patients with recurrent acute pancreatitis (RAP) treated with naldemedine or placebo for 12 months.
The effect of mild and moderate hepatic impairment on the pharmacokinetics, safety and tolerability of balcinrenone.
This Phase I clinical trial evaluated the pharmacokinetics, safety, and tolerability of balcinrenone in individuals with mild and moderate hepatic impairment compared to those with normal hepatic function.
PTEN negative adenocarcinoma developed in a gastric hamartoma polyp of a Cowden syndrome patient.
A man in his 60s with Cowden syndrome, diagnosed after Lhermitte-Duclos disease, medullary thyroid carcinoma and gastrointestinal polyposis, underwent regular endoscopic surveillance.
Effects of comprehensive oral care on nasogastric tube removal in long-term care residents with dysphagia: A multi-center randomized controlled trial.
This multicenter randomized controlled trial assessed the impact of comprehensive oral care (COC) on nasogastric (NG) tube removal in long-term care residents with dysphagia.
GIP contributes to postprandial regulation of splanchnic blood supply in humans with type 2 diabetes: a randomised, single-blinded, placebo-controlled, crossover study.
This randomized, single-blinded, placebo-controlled crossover study examined the role of endogenous glucose-dependent insulinotropic polypeptide (GIP) in postprandial splanchnic blood flow in ten individuals with type 2…
Beyond incontinence: a systematic review and meta-analysis of sexual dysfunction after anal fistula surgery.
This systematic review and meta-analysis evaluated the impact of anal fistula surgery on sexual function, revealing significant sex differences.
Refractory hypercalcemia due to iatrogenic unintentional Vitamin D intoxication unmasked by pancreatitis: Lessons learnt from an atypical case.
A 64-year-old man presented with severe abdominal pain, vomiting, and symptoms of hypercalcemia, including polyuria and weight loss. Laboratory tests revealed significantly elevated calcium levels and renal impairment.
Genomic and molecular landscape of early onset colorectal cancer: Emerging insights and clinical implications-A systematic review.
This systematic review analyzed the genomic and molecular characteristics of early onset colorectal cancer (EOCRC) in approximately 19,888 patients.
The Efficacy and Safety of Clip-Assisted Endoscopic Cyanoacrylate Injection for Gastric Varices: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the efficacy and safety of clip-assisted endoscopic cyanoacrylate injection (Clip-ECI) for treating gastric varices in 783 patients.
Effect of continuous energy restriction combined with probiotic supplementation on parameters related to homeostatic and hedonic systems of food intake in adult men living with obesity: Data from a randomized, parallel, double-blind, placebo-controlled clinical trial.
This randomized, double-blind, placebo-controlled trial evaluated the effects of continuous energy restriction (CER) combined with probiotic supplementation on appetite-related hormones and eating behaviors in adult men…
Elobixibat Versus Prucalopride in Functional Constipation: A Prospective Comparative Effectiveness Study.
This multicenter, pragmatic clinical trial compared the efficacy of elobixibat and prucalopride in treating functional constipation (FC) in adults.
June 20266
Perioperative tislelizumab for early-stage hepatocellular carcinoma: A phase II trial with integrated tumour microenvironment profiling and predictive modeling.
This phase II trial evaluated tislelizumab monotherapy as a neoadjuvant treatment for 36 patients with resectable early-stage hepatocellular carcinoma (HCC).
Oat-Rich Low-Gluten Diet Modulates Plasma Short-Chain Fatty Acids without Significant Changes in Fecal Microbiome or Inflammatory Markers-A Randomized Clinical Trial in People with Cardiometabolic Risk.
This randomized controlled trial examined the effects of an oat-rich low-gluten diet (LGD) on plasma short-chain fatty acids (SCFAs), fecal microbiome, and inflammatory markers in 69 individuals with cardiometabolic…
Supra-papillary versus trans-papillary stenting for malignant biliary obstruction: an updated meta-analysis of randomized trials.
This meta-analysis compared supra-papillary and trans-papillary stenting in 161 patients with malignant biliary obstruction.
Chinese herbal medicine Xiangsu Hewei Granules in treating non-erosive gastroesophageal reflux disease with liver stomach stagnation heat syndrome: A multicentre, randomized, double-blind, placebo-controlled trial.
This multicentre, randomized, double-blind, placebo-controlled trial evaluated the efficacy and safety of Xiangsu Hewei Granules in 480 patients with non-erosive gastroesophageal reflux disease (NERD) and liver stomach…
The clinical relevance of regional lymph node microarchitecture in oesophageal cancer patients - Results from the UK MRC OE02 trial.
This randomized controlled trial examined the impact of neoadjuvant chemotherapy on lymph node microarchitecture in 333 oesophageal cancer patients.
Meta-analysis of Short-term Clinical and Survival Outcomes of Full-left-full-right Split Liver Transplantation for 2 Recipients.
This meta-analysis evaluated the outcomes of full-left-full-right split liver transplantation (FLFR-SLT) for two recipients, comparing it to whole liver transplantation (WLT) and between full-right and full-left grafts.
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