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1333 articles
October 202624
Incisional Negative Pressure Wound Therapy for Prevention of Surgical Site Infection: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis pooled 85 randomised clinical trials involving 16,980 adults with primarily closed surgical incisions to compare incisional negative pressure wound therapy (iNPWT) with standard…
First-line biologic and targeted synthetic DMARDs versus methotrexate in early rheumatoid arthritis: a meta-analysis of remission outcomes.
This systematic review and meta-analysis of randomized trials compared initial biologic and targeted synthetic DMARDs (b/tsDMARDs), alone or with methotrexate, against methotrexate in methotrexate-naïve adults with…
Preoperative High-Dose Corticosteroids in Digestive Cancer Surgery: A Randomized Clinical Trial.
This multicenter, double-blind, placebo-controlled superiority randomized trial assessed whether preoperative high-dose corticosteroids improve outcomes after elective, curative-intent surgery for digestive cancer.
The Acceptability and Experiences of Participating in a Preoperative Intentional Weight-Loss Programme From Diagnosis to Surgery for Colorectal Cancer.
This qualitative study, embedded in the CARE randomised controlled trial, explored how patients with colorectal cancer experienced an intensive, dietitian-supported weight-loss programme between diagnosis and surgery.
Digital health interventions for psychological and cognitive care in cancer patients and caregivers: A RE-AIM-based systematic review.
This PRISMA-guided systematic review assessed the internal and external validity of digital interventions for psychological and cognitive concerns among people with cancer, caregivers, and family members, using the…
Development of HOPES Intervention for a Randomized Controlled Trial to Reduce the Perceived Stigma Among Women Living With HIV/AIDS in China.
This study developed and pilot-tested HOPES, a culturally grounded WeChat program intended to reduce HIV-related stigma among Chinese women living with HIV/AIDS.
Longitudinal clinical outcomes after amyloid clearance in aducanumab phase 3 studies.
This exploratory analysis pooled participants from the randomized phase 3 ENGAGE and EMERGE aducanumab trials who entered a long-term extension or later redosing study.
Chatbot Intervention and Cancer Risk Knowledge in Adolescents and Young Adults With Cancer Predisposition: A Randomized Clinical Trial.
This multicentre randomized clinical trial evaluated whether a tailored electronic chatbot improved cancer-risk understanding among English-speaking adolescents and young adults aged 12 to 24 years with one of nine…
Effect of a Computer-Aided Device on Endoscopists' Biopsy Practice for Gastric Neoplasms: A Secondary Analysis of a Randomized Controlled Trial.
This secondary analysis of a randomized controlled trial compared AI-assisted with standard gastric screening, examining biopsy practice for documented lesions.
Neural correlates of acute task-related stress in humans: a systematic review and coordinate-based ALE meta-analysis.
This systematic review and ALE meta-analysis examined the neural correlates of acute task-related stress using task-based fMRI studies.
Updated Meta-Analysis of Left Atrial Appendage Closure Versus Oral Anticoagulation to Prevent Stroke in Atrial Fibrillation.
This systematic review and meta-analysis pooled six randomized controlled trials comparing percutaneous left atrial appendage closure (LAAC) with oral anticoagulation in 7028 patients with nonvalvular atrial…
Age at Iatrogenic Menopause and Cardiovascular Morbidity and Mortality: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the cardiovascular morbidity and mortality associated with iatrogenic menopause in 2,617,942 women.
Prevalence and Predictors of Depressive Symptom Trajectories in Older Adults: A Systematic Review.
This systematic review examined longitudinal patterns of depressive symptoms and their predictors among adults aged 60 years or older.
A systematic review and meta-analysis of preoperative MRI-based pelvimetry in predicting surgical difficulty in rectal cancer: Implications for personalised surgical planning.
This systematic review and meta-analysis evaluated the role of MRI-based pelvimetry in predicting surgical difficulty during total mesorectal excision (TME) for rectal cancer, involving 8,364 patients across 36 studies.
Hair Follicle-Derived Grafting for Chronic Cutaneous Wounds: A Systematic Review of Clinical Outcomes.
This systematic review evaluated the clinical outcomes of hair follicle-derived grafting techniques for chronic cutaneous wounds, analyzing 16 studies with 239 patients.
Efficacy of US-guided Hydrodissection for Carpal Tunnel Syndrome: A Prospective Randomized Controlled Trial.
This prospective randomized controlled trial evaluated the efficacy of three US-guided hydrodissection techniques for treating carpal tunnel syndrome (CTS) in adults with refractory symptoms.
Quercetin in Myocardial Ischemia-Reperfusion Injury: Mechanistic Evidence, Cardioprotective Effects, and Translational Challenges.
This systematic review assessed the cardioprotective effects of quercetin in myocardial ischemia-reperfusion (I/R) injury, primarily in preclinical studies.
Temporal Patterns of Outcomes After DMARD Tapering or Withdrawal in Rheumatoid Arthritis With Sustained Disease Control: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the effects of DMARD tapering and withdrawal in patients with rheumatoid arthritis (RA) who had sustained disease control.
Effectiveness of a Sodium Intake Monitoring Smartphone Application (NamakBan) on Clinical Outcomes of Patients Diagnosed With Hypertension: A Randomized Clinical Trial.
This randomized clinical trial evaluated the effectiveness of the NamakBan smartphone application for monitoring sodium intake in 88 adults with primary hypertension.
Association of white blood cell count with treatment response to cefepime versus piperacillin-tazobactam.
This randomized controlled trial analyzed the impact of white blood cell (WBC) count on the effectiveness of cefepime versus piperacillin-tazobactam in treating sepsis.
Topical Anesthetics Effectiveness in Management of Orthodontic Pain: A Systematic Review of Randomized Controlled Trials.
This systematic review evaluated the effectiveness of topical anesthetics in managing orthodontic pain, analyzing nine randomized controlled trials involving 456 participants aged 14-35.
Contact Allergens Associated With Nummular Eczema: A Systematic Review.
This systematic review examined the association between contact allergens and nummular eczema (NE) by analyzing 10 observational studies.
NIHSS and Large Artery Atherosclerosis Affect Efficacy of Dual Antiplatelet Therapy Versus Alteplase for Minor Stroke.
This randomized controlled trial analyzed the efficacy of dual antiplatelet therapy (DAPT) versus alteplase in patients with minor stroke (NIHSS 0-5) and assessed the impact of large artery atherosclerosis (LAA).
Efficacy and Safety of Traditional Chinese Medicine in Treating Chronic Obstructive Pulmonary Disease with Osteoporosis: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the efficacy and safety of traditional Chinese medicine (TCM) as an adjunct to conventional treatment for chronic obstructive pulmonary disease (COPD) with osteoporosis…
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