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1998 articles
October 202624
Early-onset VEXAS syndrome mimicking orbital cellulitis and successfully treated with allogeneic hematopoietic stem cell transplantation.
A 25-year-old male presented with recurrent fever, weight loss, arthralgia, and symptoms resembling orbital cellulitis. Imaging revealed orbital soft tissue inflammation, while laboratory tests showed macrocytic anemia…
Cardiovascular safety in middle-aged and older men under testosterone replacement therapy: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the cardiovascular safety of testosterone replacement therapy (TRT) in middle-aged and older men, analyzing data from 31 randomized-controlled trials involving 9,437…
Ventriculo-arterial coupling in acute heart failure: prognostic and therapeutic insights - a systematic review and meta-analysis of multivariable-adjusted data.
This systematic review and meta-analysis evaluated the prognostic significance of non-invasive ventricular-arterial coupling (VAC) in 36,989 patients hospitalized with acute heart failure (AHF).
Early structured rehabilitation following open retromuscular incisional hernia repair: a prospective randomized controlled trial.
This randomized controlled trial evaluated the impact of structured early rehabilitation on functional recovery after open retromuscular incisional hernia repair in 30 adults.
Comparative efficacy and safety of orally administered PCSK9 inhibitors in patients with Hypercholesterolaemia: a dose-stratified systematic review and network meta-analysis.
This network meta-analysis evaluated the efficacy and safety of orally administered PCSK9 inhibitors in patients with hypercholesterolemia, analyzing five randomized trials with 4,227 participants.
Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis.
This individual participant data meta-analysis examined amyloid PET scans from 49,227 participants across 53 studies to establish Centiloid positivity cutoffs for Alzheimer disease diagnosis.
Outcomes after middle meningeal artery embolization using coils alone for chronic subdural hematoma: A systematic review and single-arm meta-analysis.
This systematic review and single-arm meta-analysis evaluated the outcomes of coil-only middle meningeal artery embolization (MMAE) for chronic subdural hematoma (cSDH) in 397 patients across 10 studies.
A Systematic Review of Stem Cell Secretome-Derived Exosomes for Neuropathic Pain: Therapeutic Mechanisms and Translational Potential.
This systematic review assessed the therapeutic mechanisms and potential of stem cell secretome-derived exosomes for neuropathic pain (NP) in preclinical and clinical studies.
Effectiveness of Chatbots in Mental Health Screening and Assessment: Systematic Review.
This systematic review evaluated the effectiveness of chatbots and AI-based conversational agents for mental health screening and assessment in adults.
Efficacy and safety of MEK inhibitors for NF1-associated symptomatic, inoperable plexiform neurofibromas: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the efficacy and safety of MEK inhibitors for treating symptomatic, inoperable plexiform neurofibromas in patients with neurofibromatosis type 1 (NF1).
Haemophagocytic lymphohistiocytosis triggered by Kikuchi-Fujimoto disease: a diagnostic challenge.
A man in his 40s presented with fever, confusion, a widespread erythematous rash, weight loss, and generalized lymphadenopathy over three weeks.
Pyelolymphatic backflow demonstrated on computed tomography urography in acute ureteric obstruction.
A man in his early 40s presented with acute right flank pain, vomiting and dysuria. Ultrasonography demonstrated an obstructing right upper ureteric calculus with a contralateral renal calculus.
Eosinophilic angiocentric fibrosis in paediatric IgG4-related disease.
A young girl presented with a 1.5-year history of progressive bilateral upper eyelid swelling and proptosis, more pronounced on the right.
Effectiveness of Immersive and Embodied Enhancement via "Virtual Reality" on the Sustainability of Hand Hygiene Compliance:Protocol for a Randomized Controlled Trial of a School-Based Training Program.
This protocol describes a three-arm randomized controlled trial evaluating customized virtual reality (VR) handwashing education among secondary school students in Hong Kong.
5-year survival rate and determinants of decreased survival among patients with breast cancer in Africa: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the 5-year survival rate of breast cancer patients in Africa, analyzing 55 studies with 19,577 participants. The pooled 5-year survival rate was found to be 40.38%.
Duplicated spermatic cord encountered during inguinal hernia repair.
A male patient in his seventies presented for elective open right inguinal hernia repair. During the procedure, complete duplication of the spermatic cord was identified, with two distinct structures each containing a…
Randomised controlled trial of fluoxetine versus naltrexone in compulsive sexual behaviour disorder.
This randomized controlled trial compared the efficacy and tolerability of fluoxetine and naltrexone in 80 participants with compulsive sexual behaviour disorder (CSBD).
Neuromuscular, Balance, and Gait Factors Associated with Falls and Fall-Related Outcomes in Individuals with COPD: A Systematic Review.
This systematic review examined associations between muscle strength, balance, gait and falls or fall-related outcomes in people with COPD. It included 25 original studies involving 1295 participants.
Approach to management of walled-off necrosis secondary to trauma-induced pancreatitis in a limited-resource setting.
A patient with trauma-induced pancreatitis developed a walled-off necrosis (WON) characterized by a necrotic peripancreatic collection. Imaging revealed a mature collection with necrotic debris.
Smartphone Measurement Application for Percutaneous Vertebroplasty in Osteoporotic Vertebral Compression Fractures: A Randomized Trial.
This single-center randomized controlled trial compared a LiDAR-enabled smartphone measurement application with conventional anatomical localization and C-arm verification in 43 patients with acute thoracolumbar…
Chronic posthypoxic myoclonus: Lance-Adams syndrome.
A man in his 20s developed chronic intentional myoclonus following two cardiac arrests, leading to persistent generalized myoclonic seizures.
Leveraging Longitudinal DBS Recordings to Probe Pharmacological Mechanisms: Investigating the Role of Orexin Antagonists on Extended Amygdala Activity.
A patient with severe, treatment-refractory obsessive-compulsive disorder and comorbid insomnia had beta activity recorded longitudinally from the bed nucleus of the stria terminalis (BNST) using implanted deep brain…
Rupture of Left Ventricular Aneurysm in Infant: Case Report.
A preterm infant hospitalized from birth with necrotizing enterocolitis, later complicated by ascending-colon narrowing requiring surgery, had persistent infections with Staphylococcus haemolyticus and then…
Adamantinoma-like Ewing sarcoma of the bladder.
A patient presented with a bladder tumor initially diagnosed as urothelial carcinoma following transurethral resection. After receiving neoadjuvant chemotherapy with methotrexate, vinblastine, doxorubicin, and…
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