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1998 articles
October 202624
Haemodynamic and neurophysiological assessments for 2-year outcome prediction in neonates with hypoxic-ischaemic encephalopathy treated with therapeutic hypothermia: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the prognostic accuracy of amplitude-integrated electroencephalography (aEEG), cerebral near-infrared spectroscopy (cNIRS), and targeted neonatal echocardiography…
Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Cognitive Outcome after Stroke: A Systematic Review.
This systematic review examined the association between the BDNF Val66Met polymorphism and cognitive outcomes in 2,494 adults post-stroke.
HD-tACS at 40 Hz improves consciousness and brain connectivity in prolonged disorders of consciousness: a randomized sham-controlled clinical trial.
This randomized, sham-controlled clinical trial evaluated 40 Hz and 4 Hz high-definition transcranial alternating current stimulation (HD-tACS) in 60 patients with prolonged disorders of consciousness.
Bone Anabolic Treatment in Patients With Chronic Kidney Disease: A Systematic Review.
This systematic review evaluated the efficacy and safety of anabolic parathyroid hormone (PTH) treatments in patients with chronic kidney disease (CKD) Stages 4-5D.
Vitamin D Supplementation and Mortality in the Elderly: A Review of a Meta-Analysis of Randomized Controlled Trials Using the REB Method.
This meta-analysis reviewed 25 randomized controlled trials (RCTs) to evaluate the impact of vitamin D supplementation on mortality in individuals aged 75 and older.
Metabolomic biomarkers and metabolic remodelling in genetically characterised hypertrophic cardiomyopathy: a systematic review.
This systematic review examined metabolomic evidence in 1511 participants with genetically characterised hypertrophic cardiomyopathy (HCM).
Concordance of Microbiological and Histopathological Examination of Bone Biopsies in Diagnosing Diabetic Foot Osteomyelitis, a Systematic Review.
This systematic review evaluated the diagnostic concordance of histopathology and microbiology in bone biopsies from 308 adults with diabetic foot osteomyelitis (DFO).
Impact of digital health interventions in improving pediatric immunization coverage and timeliness in low- and middle-income countries: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed randomized controlled trials of digital interventions to improve pediatric vaccination outcomes in low- and middle-income countries.
Hypofractionated 44 Gy in 20 fractions versus conventional chemoradiation in cervical cancer: 2-year results of the randomized HYPOCx-iRex trial with an exploratory pooled analysis of a single-institute EMBRACE-II cohort.
The randomized HYPOCx-iRex trial compared hypofractionated chemoradiation (44 Gy in 20 fractions) with conventional chemoradiation (45 Gy in 25 fractions) for locally advanced cervical cancer; an exploratory pooled…
Inflammatory and Autoimmune Axonal Neuropathies.
This article outlines the clinical patterns, diagnostic strategies, and treatment principles for patients with inflammatory and autoimmune axonal neuropathies.
Effects of SGLT-2 Inhibitors on Plasma Concentrations and Renal Clearance of the Risk Marker Trimethylamine-N-Oxide in Patients With Type-2 Diabetes.
This randomized controlled trial investigated the effects of SGLT-2 inhibitors empagliflozin and dapagliflozin on plasma levels and renal clearance of trimethylamine-N-oxide (TMAO) in patients with Type 2 diabetes.
Rapid manufactured CAR-T cells enriched for CD45RA-negative T cells exhibit superior persistence compared to conventional CAR-T therapy.
This comparative study evaluated InstanCAR-T, a rapid CD19 CAR-T manufacturing protocol enriched for CD45RA-negative T cells, against conventional CAR-T in laboratory assays, murine B-ALL models, and a Phase I clinical…
Paraproteinemic Neuropathies.
Paraproteinemic neuropathies present with a myriad of phenotypes and associated underlying plasma cell dyscrasias. This article provides a phenotype-driven approach to the evaluation of paraproteinemic neuropathies…
Comparison of Molecular Methods With Culture for Identifying Microbial Etiology in Pediatric Empyema Thoracis: A Systematic Review of Diagnostic Test Accuracy.
This systematic review evaluated the diagnostic accuracy of molecular methods versus culture for identifying microbial etiology in pediatric empyema thoracis.
Attachment styles and problematic involvement in potentially addictive behaviours: A systematic review and meta-analysis.
This systematic review and meta-analysis examined associations between attachment styles and problematic involvement in behaviours described as addictions, using peer-reviewed studies published before July 23rd, 2026.
Efficacy and Safety of Oral Non-Statin Lipid-Lowering Therapies in Dyslipidaemia: A Systematic Review and Network Meta-Analysis.
This systematic review and network meta-analysis evaluated the efficacy and safety of oral non-statin lipid-lowering therapies in adults with dyslipidaemia.
Diagnostic Approach to Neuropathy.
This article provides an updated overview of polyneuropathy, emphasizing the significance of accurate diagnosis and the evolving understanding of its underlying causes and pathophysiology.
Small Fiber Neuropathy.
Small fiber neuropathy is a common disorder; however, its diagnosis and treatment can be challenging. This article outlines the pain pathways involved in small fiber neuropathy and provides an overview of its various…
Native collagen matrix plus PHMB antimicrobial in hard-to-heal diabetic foot ulcers: results from the PREPARE randomised controlled trial.
The PREPARE prospective, multicentre randomised controlled trial compared purified native type 1 collagen extracellular matrix plus polyhexamethylene biguanide (PCMP) with standard care (SoC) alone in patients with…
Markedly Elevated CA 19-9 in Type I Mirizzi Syndrome in the Absence of Malignancy: A Case Report.
A 50-year-old man presented with acute obstructive jaundice, fever, and right upper quadrant pain; serum CA 19-9 was 1000 U/mL.
Non-Ischemic Cerebral Enhancing (NICE) lesions after flow diversion for intracranial aneurysms: a systematic review with case-level synthesis.
This PROSPERO-registered systematic review synthesized reports of delayed non-ischemic cerebral enhancing (NICE) lesions after flow-diverter treatment of intracranial aneurysms; heterogeneity precluded meta-analysis.
Isolated Prostatic Tuberculosis Coexisting with Benign Prostatic Hyperplasia: A Case Report.
A 70-year-old man presented with one month of lower urinary tract symptoms and recurrent urinary retention requiring repeated catheterization.
Clinical outcomes of early versus standard liver transplantation in patients with alcohol-related liver disease: a meta-analysis.
This meta-analysis compared early and standard liver transplantation in patients with alcohol-related liver disease. It included 12 studies and 2323 patients.
Comparisons in Analgesic Effects Between Ultrasound-Guided Erector Spinae Plane Block and Ultrasound-Guided Modified Intercostal Nerve Block in Modified Radical Mastectomy: A Randomized Controlled Trial.
Postoperative acute pain is a common challenge after breast cancer surgery. This randomized controlled trial compared the analgesic effects of ultrasound-guided erector spinae plane block (ESPB) and modified intercostal…
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